Contrast-enhanced T1 mapping-based extracellular volume fraction independently predicts clinical outcome in patients with non-ischemic dilated cardiomyopathy: a prospective cohort study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-24

AUTHORS

Jong-Chan Youn, Yoo Jin Hong, Hye-Jeong Lee, Kyunghwa Han, Chi Young Shim, Geu-Ru Hong, Young Joo Suh, Jin Hur, Young Jin Kim, Byoung Wook Choi, Seok-Min Kang

ABSTRACT

ObjectivesWe aimed to evaluate the prognostic role of cardiac magnetic resonance imaging (CMR)–based extracellular volume fraction (ECV) in patients with non-ischemic dilated cardiomyopathy (NIDCM) and compare it with late gadolinium enhancement (LGE) parameters.MethodsThis was a single-center, prospective, cohort study of 117 NIDCM patients (71 men, 51.9 ± 16.7 years) who underwent clinical 3.0-T CMR. Myocardial ECV and LGE were quantified on the left ventricular myocardium. The presence of midwall LGE was also detected. Nineteen healthy subjects served as controls. The primary end points were cardiovascular (CV) events defined by CV death, rehospitalization due to heart failure, and heart transplantation.ResultsDuring the follow-up period (median duration, 11.2 months; 25th–75th percentile, 7.8–21.9 months), the primary end points occurred in 19 patients (16.2%). The ECV (per 3% and 1% increase) was associated with a hazard ratio of 1.80 and 1.22 (95% confidence interval [CI], 1.48–2.20 and 1.14–1.30, respectively; p < 0.001) for the CV events. Multivariable analysis also indicated that ECV was an independent prognostic factor and had a higher prognostic value (Harrell’s c statistic, 0.88) than LGE quantification values (0.77) or midwall LGE (0.80).ConclusionCMR-based ECV independently predicts the clinical outcome in NIDCM patients.Key Points• T1-mapping–based ECV is a useful parameter of risk stratification in NIDCM• ECV has a higher prognostic value than LGE• Contrast-enhanced T1-mapping CMR is a feasible and safe method More... »

PAGES

3924-3933

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-017-4817-9

DOI

http://dx.doi.org/10.1007/s00330-017-4817-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085052251

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28439651


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25 schema:description ObjectivesWe aimed to evaluate the prognostic role of cardiac magnetic resonance imaging (CMR)–based extracellular volume fraction (ECV) in patients with non-ischemic dilated cardiomyopathy (NIDCM) and compare it with late gadolinium enhancement (LGE) parameters.MethodsThis was a single-center, prospective, cohort study of 117 NIDCM patients (71 men, 51.9 ± 16.7 years) who underwent clinical 3.0-T CMR. Myocardial ECV and LGE were quantified on the left ventricular myocardium. The presence of midwall LGE was also detected. Nineteen healthy subjects served as controls. The primary end points were cardiovascular (CV) events defined by CV death, rehospitalization due to heart failure, and heart transplantation.ResultsDuring the follow-up period (median duration, 11.2 months; 25th–75th percentile, 7.8–21.9 months), the primary end points occurred in 19 patients (16.2%). The ECV (per 3% and 1% increase) was associated with a hazard ratio of 1.80 and 1.22 (95% confidence interval [CI], 1.48–2.20 and 1.14–1.30, respectively; p < 0.001) for the CV events. Multivariable analysis also indicated that ECV was an independent prognostic factor and had a higher prognostic value (Harrell’s c statistic, 0.88) than LGE quantification values (0.77) or midwall LGE (0.80).ConclusionCMR-based ECV independently predicts the clinical outcome in NIDCM patients.Key Points• T1-mapping–based ECV is a useful parameter of risk stratification in NIDCM• ECV has a higher prognostic value than LGE• Contrast-enhanced T1-mapping CMR is a feasible and safe method
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57 heart transplantation
58 high prognostic value
59 imaging
60 independent prognostic factor
61 left ventricular myocardium
62 magnetic resonance imaging
63 midwall LGE
64 multivariable analysis
65 myocardial extracellular volume fraction
66 myocardium
67 outcomes
68 parameters
69 patients
70 period
71 point
72 presence
73 primary end point
74 prognostic factors
75 prognostic role
76 prognostic value
77 prospective cohort study
78 quantification values
79 ratio
80 rehospitalization
81 resonance imaging
82 risk stratification
83 role
84 stratification
85 study
86 subjects
87 transplantation
88 useful parameter
89 values
90 ventricular myocardium
91 volume fraction
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