Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11

AUTHORS

Marcus R. Makowski, Christian H. P. Jansen, Ullrich Ebersberger, Tobias Schaeffter, Reza Razavi, Massimo Mangino, Tim D. Spector, Rene M. Botnar, Gerald F. Greil

ABSTRACT

OBJECTIVES: The aim of this study was to investigate the impact of BMI on late gadolinium enhancement (LGE) of the coronary artery wall in identical monozygous twins discordant for BMI. Coronary LGE represents a useful parameter for the detection and quantification of atherosclerotic coronary vessel wall disease. METHODS: Thirteen monozygote female twin pairs (n = 26) with significantly different BMIs (>1.6 kg/m2) were recruited out of >10,000 twin pairs (TwinsUK Registry). A coronary 3D-T2prep-TFE MR angiogram and 3D-IR-TFE vessel wall scan were performed prior to and following the administration of 0.2 mmol/kg of Gd-DTPA on a 1.5 T MR scanner. The number of enhancing coronary segments and contrast to noise ratios (CNRs) of the coronary wall were quantified. RESULTS: An increase in BMI was associated with an increased number of enhancing coronary segments (5.3 ± 1.5 vs. 3.5 ± 1.6, p < 0.0001) and increased coronary wall enhancement (6.1 ± 1.1 vs. 4.8 ± 0.9, p = 0.0027) compared to matched twins with lower BMI. CONCLUSIONS: This study in monozygous twins indicates that acquired factors predisposing to obesity, including lifestyle and environmental factors, result in increased LGE of the coronary arteries, potentially reflecting an increase in coronary atherosclerosis in this female study population. KEY POINTS: • BMI-discordant twins allow the investigation of the influence of lifestyle factors independent from genetic confounders. • Only thirteen obesity-discordant twins were identified underlining the strong genetic component of BMI. • In female twins, a BMI increase is associated with increased coronary late gadolinium enhancement. • Increased late gadolinium enhancement in the coronary vessel wall potentially reflects increased atherosclerosis. More... »

PAGES

4612-4618

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-016-4616-8

DOI

http://dx.doi.org/10.1007/s00330-016-4616-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007437362

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27743116


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    "description": "OBJECTIVES: The aim of this study was to investigate the impact of BMI on late gadolinium enhancement (LGE) of the coronary artery wall in identical monozygous twins discordant for BMI. Coronary LGE represents a useful parameter for the detection and quantification of atherosclerotic coronary vessel wall disease.\nMETHODS: Thirteen monozygote female twin pairs (n\u2009=\u200926) with significantly different BMIs (>1.6\u00a0kg/m2) were recruited out of >10,000 twin pairs (TwinsUK Registry). A coronary 3D-T2prep-TFE MR angiogram and 3D-IR-TFE vessel wall scan were performed prior to and following the administration of 0.2\u00a0mmol/kg of Gd-DTPA on a 1.5\u00a0T MR scanner. The number of enhancing coronary segments and contrast to noise ratios (CNRs) of the coronary wall were quantified.\nRESULTS: An increase in BMI was associated with an increased number of enhancing coronary segments (5.3\u2009\u00b1\u20091.5 vs. 3.5\u2009\u00b1\u20091.6, p\u2009<\u20090.0001) and increased coronary wall enhancement (6.1\u2009\u00b1\u20091.1 vs. 4.8\u2009\u00b1\u20090.9, p\u2009=\u20090.0027) compared to matched twins with lower BMI.\nCONCLUSIONS: This study in monozygous twins indicates that acquired factors predisposing to obesity, including lifestyle and environmental factors, result in increased LGE of the coronary arteries, potentially reflecting an increase in coronary atherosclerosis in this female study population.\nKEY POINTS: \u2022 BMI-discordant twins allow the investigation of the influence of lifestyle factors independent from genetic confounders. \u2022 Only thirteen obesity-discordant twins were identified underlining the strong genetic component of BMI. \u2022 In female twins, a BMI increase is associated with increased coronary late gadolinium enhancement. \u2022 Increased late gadolinium enhancement in the coronary vessel wall potentially reflects increased atherosclerosis.", 
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