Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours: an initial experience View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-08-23

AUTHORS

Suyon Chang, Jin Hur, Dong Jin Im, Young Joo Suh, Yoo Jin Hong, Hye-Jeong Lee, Young Jin Kim, Kyunghwa Han, Dae Joon Kim, Chang Young Lee, Ha Young Shin, Byoung Wook Choi

ABSTRACT

ObjectivesTo investigate the diagnostic value of dual-energy computed tomography (DECT) in differentiating between low- and high-risk thymomas and thymic carcinomas.MaterialsOur institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients (20 males, mean age: 55.6 years) with thymic epithelial tumour. All patients underwent DECT. For quantitative analysis, two reviewers measured the following tumour parameters: CT attenuation value in contrast Hounsfield units (CHU), iodine-related HU and iodine concentration (mg/ml). Pathological results confirmed the final diagnosis.ResultsOf the 37 thymic tumours, 23 (62.2 %) were low-risk thymomas, five (13.5 %) were high-risk thymomas and nine (24.3 %) were thymic carcinomas. According to quantitative analysis, iodine-related HU and iodine concentration were significantly different among low-risk thymomas, high-risk thymomas and thymic carcinomas (median: 29.78 HU vs. 14.55 HU vs. 19.95 HU, p = 0.001 and 1.92 mg/ml vs. 0.99 mg/ml vs. 1.18 mg/ml, p < 0.001, respectively).ConclusionDECT using a quantitative analytical method based on iodine concentration measurement can be used to differentiate among thymic epithelial tumours using single-phase scanning.Key Points• IHU and IC were lower in high-risk thymomas/carcinomas than in low-risk thymomas• IHU and IC were lower in advanced-stage thymomas than in early-stage thymomas• Dual-energy CT helps differentiate among thymic epithelial tumours. More... »

PAGES

1992-2001

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-016-4542-9

DOI

http://dx.doi.org/10.1007/s00330-016-4542-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015033288

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27553938


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30 schema:description ObjectivesTo investigate the diagnostic value of dual-energy computed tomography (DECT) in differentiating between low- and high-risk thymomas and thymic carcinomas.MaterialsOur institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients (20 males, mean age: 55.6 years) with thymic epithelial tumour. All patients underwent DECT. For quantitative analysis, two reviewers measured the following tumour parameters: CT attenuation value in contrast Hounsfield units (CHU), iodine-related HU and iodine concentration (mg/ml). Pathological results confirmed the final diagnosis.ResultsOf the 37 thymic tumours, 23 (62.2 %) were low-risk thymomas, five (13.5 %) were high-risk thymomas and nine (24.3 %) were thymic carcinomas. According to quantitative analysis, iodine-related HU and iodine concentration were significantly different among low-risk thymomas, high-risk thymomas and thymic carcinomas (median: 29.78 HU vs. 14.55 HU vs. 19.95 HU, p = 0.001 and 1.92 mg/ml vs. 0.99 mg/ml vs. 1.18 mg/ml, p < 0.001, respectively).ConclusionDECT using a quantitative analytical method based on iodine concentration measurement can be used to differentiate among thymic epithelial tumours using single-phase scanning.Key Points• IHU and IC were lower in high-risk thymomas/carcinomas than in low-risk thymomas• IHU and IC were lower in advanced-stage thymomas than in early-stage thymomas• Dual-energy CT helps differentiate among thymic epithelial tumours.
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36 schema:keywords CT
37 CT attenuation values
38 ConclusionDECT
39 DECT
40 HU
41 Hounsfield units
42 IC
43 IHU
44 ObjectivesTo
45 ResultsOf
46 advanced stage thymomas
47 analysis
48 analytical method
49 attenuation values
50 board
51 carcinoma
52 concentration
53 concentration measurements
54 consent
55 diagnosis
56 diagnostic value
57 differentiation
58 dual-energy CT
59 epithelial tumors
60 experience
61 final diagnosis
62 high-risk thymomas
63 informed consent
64 initial experience
65 institutional review board
66 iodine concentration
67 iodine concentration measurement
68 low-risk thymomas
69 measurements
70 method
71 parameters
72 pathological results
73 patients
74 quantification
75 quantitative analysis
76 quantitative analytical method
77 results
78 review board
79 reviewers
80 scanning
81 study
82 thymic carcinoma
83 thymic epithelial tumors
84 thymic tumors
85 thymoma
86 tomography
87 tumor parameters
88 tumors
89 units
90 values
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