Infraorbital nerve involvement on magnetic resonance imaging in European patients with IgG4-related ophthalmic disease: a specific sign View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07-19

AUTHORS

J. Ben Soussan, R. Deschamps, J. C. Sadik, J. Savatovsky, L. Deschamps, M. Puttermann, M. Zmuda, F. Heran, O. Galatoire, H. Picard, A. Lecler

ABSTRACT

ObjectivesTo measure the frequency of infraorbital nerve enlargement (IONE) on magnetic resonance imaging (MRI) in European patients suffering from an IgG4-related ophthalmic disease (IgG4-ROD) as compared to patients suffering from non-IgG4-related ophthalmic disease (non-IgG4-ROD).MethodsFrom January 2006 through April 2015, 132 patients were admitted for non-lymphoma, non-thyroid-related orbital inflammation. Thirty-eight had both pre-therapeutic orbital MRI and histopathological IgG4 immunostaining. Fifteen patients were classified as cases of IgG4-ROD and 23 patients as cases of non-IgG4-ROD. Two readers performed blinded analyses of MRI images. The main criterion was the presence of an IONE, defined as the infraorbital nerve diameter being greater than the optic nerve diameter in the coronal section.ResultsIONE was present in 53% (8/15) of IgG4-ROD cases whereas it was never present (0/23) in cases of non-IgG4-ROD (P < 0.0001). IONE was only present in cases where, on MRI, the inflammation of the inferior quadrant was present and in direct contact with the ION canal.ConclusionsIn European patients suffering from orbital inflammation, the presence of IONE on an MRI is a specific sign of IgG4-ROD. Recognition of this pattern may facilitate the accurate diagnosis for clinicians and allow for the adequate management and appropriate care of their patients.Key points• IONE on an MRI is a specific sign of IgG4-ROD.• IONE recognition allows for a quicker diagnosis and appropriate management.• IONE appears when inflammation is in direct contact with the ION canal. More... »

PAGES

1335-1343

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Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-016-4481-5

DOI

http://dx.doi.org/10.1007/s00330-016-4481-5

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https://app.dimensions.ai/details/publication/pub.1035567805

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27436015


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37 European patients
38 ION canal
39 IONE recognition
40 IgG4
41 IgG4-ROD
42 IgG4-ROD cases
43 IgG4-related ophthalmic disease
44 Infraorbital nerve involvement
45 MRI images
46 ObjectivesTo
47 ResultsIONE
48 accurate diagnosis
49 adequate management
50 analysis
51 appropriate care
52 appropriate management
53 blinded analysis
54 canal
55 care
56 cases
57 cases of IgG4-ROD
58 clinicians
59 contact
60 coronal sections
61 criteria
62 diagnosis
63 diameter
64 direct contact
65 disease
66 enlargement
67 frequency
68 histopathological IgG4
69 images
70 imaging
71 inferior quadrant
72 inflammation
73 infraorbital nerve diameter
74 infraorbital nerve enlargement
75 involvement
76 magnetic resonance
77 magnetic resonance imaging
78 main criteria
79 management
80 nerve diameter
81 nerve enlargement
82 nerve involvement
83 non-IgG4-related ophthalmic disease
84 ophthalmic disease
85 optic nerve diameter
86 orbital inflammation
87 orbital magnetic resonance imaging
88 patients
89 patterns
90 pre-therapeutic orbital MRI
91 presence
92 presence of IONE
93 quadrant
94 quick diagnosis
95 readers
96 recognition
97 resonance
98 resonance imaging
99 sections
100 signs
101 specific signs
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