Comparative assessment of image quality for coronary CT angiography with iobitridol and two contrast agents with higher iodine concentrations: iopromide ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06-07

AUTHORS

Stephan Achenbach, Jean-François Paul, François Laurent, Hans-Christoph Becker, Marco Rengo, Jerome Caudron, Sebastian Leschka, Olivier Vignaux, Gesine Knobloch, Giorgio Benea, Thomas Schlosser, Jordi Andreu, Beatriz Cabeza, Alexis Jacquier, Miguel Souto, Didier Revel, Salah Dine Qanadli, Filippo Cademartiri, on behalf of the X-ACT Study Group

ABSTRACT

ObjectivesTo demonstrate non-inferiority of iobitridol 350 for coronary CT angiography (CTA) compared to higher iodine content contrast media regarding rate of patients evaluable for the presence of coronary artery stenoses.MethodsIn this multicentre trial, 452 patients were randomized to receive iobitridol 350, iopromide 370 or iomeprol 400 and underwent coronary CTA using CT systems with 64-detector rows or more. Two core lab readers assessed 18 coronary segments per patient regarding image quality (score 0 = non diagnostic to 4 = excellent quality), vascular attenuation, signal and contrast to noise ratio (SNR, CNR). Patients were considered evaluable if no segment had a score of 0.ResultsPer-patient, the rate of fully evaluable CT scans was 92.1, 95.4 and 94.6 % for iobitridol, iopromide and iomeprol, respectively. Non-inferiority of iobitridol over the best comparator was demonstrated with a 95 % CI of the difference of [-8.8 to 2.1], with a pre-specified non-inferiority margin of -10 %. Although average attenuation increased with higher iodine concentrations, average SNR and CNR did not differ between groups.ConclusionsWith current CT technology, iobitridol 350 mg iodine/ml is not inferior to contrast media with higher iodine concentrations in terms of image quality for coronary stenosis assessment.Key Points• Iodine concentration is an important parameter for image quality in coronary CTA.• Contrast enhancement must be balanced against the amount of iodine injected.• Iobitridol 350 is non-inferior compared to CM with higher iodine concentrations.• Higher attenuation with higher iodine concentrations, but no SNR or CNR differences. More... »

PAGES

821-830

References to SciGraph publications

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  • Journal

    TITLE

    European Radiology

    ISSUE

    2

    VOLUME

    27

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00330-016-4437-9

    DOI

    http://dx.doi.org/10.1007/s00330-016-4437-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049861943

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27271922


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