Ontology type: schema:ScholarlyArticle Open Access: True
2016-05-05
AUTHORSPejman Ghanouni, Andrew Dobrotwir, Alberto Bazzocchi, Matthew Bucknor, Rachelle Bitton, Jarrett Rosenberg, Kristen Telischak, Maurizio Busacca, Stefano Ferrari, Ugo Albisinni, Shannon Walters, Garry Gold, Kristen Ganjoo, Alessandro Napoli, Kim Butts Pauly, Raffi Avedian
ABSTRACTObjectivesTo assess the feasibility, safety and preliminary efficacy of magnetic resonance-guided focused ultrasound (MRgFUS) for the treatment of extra-abdominal desmoid tumours.MethodsFifteen patients with desmoid fibromatosis (six males, nine females; age range, 7–66 years) were treated with MRgFUS, with seven patients requiring multiple treatments (25 total treatments). Changes in viable and total tumour volumes were measured after treatment. Efficacy was evaluated using an exact one-sided Wilcoxon test to determine if the median reduction in viable tumour measured immediately after initial treatment exceeded a threshold of 50 % of the targeted volume. Median decrease after treatment of at least two points in numerical rating scale (NRS) worst and average pain scores was tested with an exact one-sided Wilcoxon test. Adverse events were recorded.ResultsAfter initial MRgFUS treatment, median viable targeted tumour volume decreased 63 %, significantly beyond our efficacy threshold (P = 0.0013). Median viable total tumour volume decreased (105 mL [interquartile range {IQR}, 217 mL] to 54 mL [IQR, 92 mL]) and pain improved (worst scores, 7.5 ± 1.9 vs 2.7 ± 2.6, P = 0.027; average scores, 6 ± 2.3 vs 1.3 ± 2, P = 0.021). Skin burn was the most common complication.ConclusionsMRgFUS significantly and durably reduced viable tumour volume and pain in this series of 15 patients with extra-abdominal desmoid fibromatosis.Key Points• Retrospective four-centre study shows MRgFUS safely and effectively treats extra-abdominal desmoid tumours• This non-invasive procedure can eradicate viable tumour in some cases• Alternatively, MRgFUS can provide durable control of tumour growth through repeated treatments• Compared to surgery or radiation, MRgFUS has relatively mild side effects More... »
PAGES732-740
http://scigraph.springernature.com/pub.10.1007/s00330-016-4376-5
DOIhttp://dx.doi.org/10.1007/s00330-016-4376-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1052956088
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/27147222
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fibromatosis, Aggressive",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "High-Intensity Focused Ultrasound Ablation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Magnetic Resonance Imaging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Magnetic Resonance Imaging, Interventional",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Soft Tissue Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Surgery, Computer-Assisted",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Burden",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Young Adult",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Radiology, Lucas Center for Imaging, Stanford University School of Medicine, 1201 Welch Road, Room P267, 94305, Stanford, CA, USA",
"id": "http://www.grid.ac/institutes/grid.168010.e",
"name": [
"Department of Radiology, Lucas Center for Imaging, Stanford University School of Medicine, 1201 Welch Road, Room P267, 94305, Stanford, CA, USA"
],
"type": "Organization"
},
"familyName": "Ghanouni",
"givenName": "Pejman",
"id": "sg:person.0723333404.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723333404.84"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Future Medical Imaging Group, Hawthorn, Victoria, Australia",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Future Medical Imaging Group, Hawthorn, Victoria, Australia"
],
"type": "Organization"
},
"familyName": "Dobrotwir",
"givenName": "Andrew",
"id": "sg:person.0731232173.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731232173.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Diagnostic and Interventional Radiology, The Rizzoli Orthopaedic Institute, Bologna, Italy",
"id": "http://www.grid.ac/institutes/grid.419038.7",
"name": [
"Department of Diagnostic and Interventional Radiology, The Rizzoli Orthopaedic Institute, Bologna, Italy"
],
"type": "Organization"
},
"familyName": "Bazzocchi",
"givenName": "Alberto",
"id": "sg:person.01236303515.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236303515.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA",
"id": "http://www.grid.ac/institutes/grid.266102.1",
"name": [
"Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA"
],
"type": "Organization"
},
"familyName": "Bucknor",
"givenName": "Matthew",
"id": "sg:person.01036226074.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036226074.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology, Lucas Center for Imaging, Stanford University School of Medicine, 1201 Welch Road, Room P267, 94305, Stanford, CA, USA",
"id": "http://www.grid.ac/institutes/grid.168010.e",
"name": [
"Department of Radiology, Lucas Center for Imaging, Stanford University School of Medicine, 1201 Welch Road, Room P267, 94305, Stanford, CA, USA"
],
"type": "Organization"
},
"familyName": "Bitton",
"givenName": "Rachelle",
"id": "sg:person.01175067443.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175067443.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology, Lucas Center for Imaging, Stanford University School of Medicine, 1201 Welch Road, Room P267, 94305, Stanford, CA, USA",
"id": "http://www.grid.ac/institutes/grid.168010.e",
"name": [
"Department of Radiology, Lucas Center for Imaging, Stanford University School of Medicine, 1201 Welch Road, Room P267, 94305, Stanford, CA, USA"
],
"type": "Organization"
},
"familyName": "Rosenberg",
"givenName": "Jarrett",
"id": "sg:person.0771671277.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771671277.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA",
"id": "http://www.grid.ac/institutes/grid.168010.e",
"name": [
"Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA"
],
"type": "Organization"
},
"familyName": "Telischak",
"givenName": "Kristen",
"id": "sg:person.01200676057.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200676057.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Diagnostic and Interventional Radiology, The Rizzoli Orthopaedic Institute, Bologna, Italy",
"id": "http://www.grid.ac/institutes/grid.419038.7",
"name": [
"Department of Diagnostic and Interventional Radiology, The Rizzoli Orthopaedic Institute, Bologna, Italy"
],
"type": "Organization"
},
"familyName": "Busacca",
"givenName": "Maurizio",
"id": "sg:person.01206620122.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206620122.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Oncology, The Rizzoli Orthopaedic Institute, Bologna, Italy",
"id": "http://www.grid.ac/institutes/grid.419038.7",
"name": [
"Department of Oncology, The Rizzoli Orthopaedic Institute, Bologna, Italy"
],
"type": "Organization"
},
"familyName": "Ferrari",
"givenName": "Stefano",
"id": "sg:person.013005321532.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013005321532.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Diagnostic and Interventional Radiology, The Rizzoli Orthopaedic Institute, Bologna, Italy",
"id": "http://www.grid.ac/institutes/grid.419038.7",
"name": [
"Department of Diagnostic and Interventional Radiology, The Rizzoli Orthopaedic Institute, Bologna, Italy"
],
"type": "Organization"
},
"familyName": "Albisinni",
"givenName": "Ugo",
"id": "sg:person.0627126015.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627126015.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology, Lucas Center for Imaging, Stanford University School of Medicine, 1201 Welch Road, Room P267, 94305, Stanford, CA, USA",
"id": "http://www.grid.ac/institutes/grid.168010.e",
"name": [
"Department of Radiology, Lucas Center for Imaging, Stanford University School of Medicine, 1201 Welch Road, Room P267, 94305, Stanford, CA, USA"
],
"type": "Organization"
},
"familyName": "Walters",
"givenName": "Shannon",
"id": "sg:person.01354561577.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354561577.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology, Lucas Center for Imaging, Stanford University School of Medicine, 1201 Welch Road, Room P267, 94305, Stanford, CA, USA",
"id": "http://www.grid.ac/institutes/grid.168010.e",
"name": [
"Department of Radiology, Lucas Center for Imaging, Stanford University School of Medicine, 1201 Welch Road, Room P267, 94305, Stanford, CA, USA"
],
"type": "Organization"
},
"familyName": "Gold",
"givenName": "Garry",
"id": "sg:person.01126443313.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126443313.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA",
"id": "http://www.grid.ac/institutes/grid.168010.e",
"name": [
"Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA"
],
"type": "Organization"
},
"familyName": "Ganjoo",
"givenName": "Kristen",
"id": "sg:person.01273551446.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273551446.67"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology, Sapienza University, Rome, Italy",
"id": "http://www.grid.ac/institutes/grid.7841.a",
"name": [
"Department of Radiology, Sapienza University, Rome, Italy"
],
"type": "Organization"
},
"familyName": "Napoli",
"givenName": "Alessandro",
"id": "sg:person.01351075172.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351075172.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology, Lucas Center for Imaging, Stanford University School of Medicine, 1201 Welch Road, Room P267, 94305, Stanford, CA, USA",
"id": "http://www.grid.ac/institutes/grid.168010.e",
"name": [
"Department of Radiology, Lucas Center for Imaging, Stanford University School of Medicine, 1201 Welch Road, Room P267, 94305, Stanford, CA, USA"
],
"type": "Organization"
},
"familyName": "Pauly",
"givenName": "Kim Butts",
"id": "sg:person.010722224007.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010722224007.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA, USA",
"id": "http://www.grid.ac/institutes/grid.168010.e",
"name": [
"Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA, USA"
],
"type": "Organization"
},
"familyName": "Avedian",
"givenName": "Raffi",
"id": "sg:person.0677226377.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677226377.22"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1245/s10434-015-4453-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000965244",
"https://doi.org/10.1245/s10434-015-4453-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11999-015-4364-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045814695",
"https://doi.org/10.1007/s11999-015-4364-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00330-008-0906-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001123220",
"https://doi.org/10.1007/s00330-008-0906-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00256-009-0801-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037595159",
"https://doi.org/10.1007/s00256-009-0801-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00330-014-3538-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012224614",
"https://doi.org/10.1007/s00330-014-3538-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-012-2634-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049399810",
"https://doi.org/10.1245/s10434-012-2634-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-012-2638-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032141881",
"https://doi.org/10.1245/s10434-012-2638-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11864-013-0235-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004505367",
"https://doi.org/10.1007/s11864-013-0235-7"
],
"type": "CreativeWork"
}
],
"datePublished": "2016-05-05",
"datePublishedReg": "2016-05-05",
"description": "ObjectivesTo assess the feasibility, safety and preliminary efficacy of magnetic resonance-guided focused ultrasound (MRgFUS) for the treatment of extra-abdominal desmoid tumours.MethodsFifteen patients with desmoid fibromatosis (six males, nine females; age range, 7\u201366\u00a0years) were treated with MRgFUS, with seven patients requiring multiple treatments (25 total treatments). Changes in viable and total tumour volumes were measured after treatment. Efficacy was evaluated using an exact one-sided Wilcoxon test to determine if the median reduction in viable tumour measured immediately after initial treatment exceeded a threshold of 50\u00a0% of the targeted volume. Median decrease after treatment of at least two points in numerical rating scale (NRS) worst and average pain scores was tested with an exact one-sided Wilcoxon test. Adverse events were recorded.ResultsAfter initial MRgFUS treatment, median viable targeted tumour volume decreased 63\u00a0%, significantly beyond our efficacy threshold (P\u2009=\u20090.0013). Median viable total tumour volume decreased (105\u00a0mL [interquartile range {IQR}, 217\u00a0mL] to 54\u00a0mL [IQR, 92\u00a0mL]) and pain improved (worst scores, 7.5\u2009\u00b1\u20091.9 vs 2.7\u2009\u00b1\u20092.6, P\u2009=\u20090.027; average scores, 6\u2009\u00b1\u20092.3 vs 1.3\u2009\u00b1\u20092, P\u2009=\u20090.021). Skin burn was the most common complication.ConclusionsMRgFUS significantly and durably reduced viable tumour volume and pain in this series of 15 patients with extra-abdominal desmoid fibromatosis.Key Points\u2022 Retrospective four-centre study shows MRgFUS safely and effectively treats extra-abdominal desmoid tumours\u2022 This non-invasive procedure can eradicate viable tumour in some cases\u2022 Alternatively, MRgFUS can provide durable control of tumour growth through repeated treatments\u2022 Compared to surgery or radiation, MRgFUS has relatively mild side effects",
"genre": "article",
"id": "sg:pub.10.1007/s00330-016-4376-5",
"inLanguage": "en",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2435873",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1289120",
"issn": [
"0938-7994",
"1432-1084"
],
"name": "European Radiology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "27"
}
],
"keywords": [
"extra-abdominal desmoid tumors",
"numerical rating scale",
"total tumor volume",
"tumor volume",
"viable tumor",
"desmoid tumors",
"desmoid fibromatosis",
"extra-abdominal desmoid fibromatosis",
"extra-abdominal desmoids",
"magnetic resonance-guided focused ultrasound treatment",
"average pain score",
"retrospective multicenter study",
"magnetic resonance-guided focused ultrasound",
"Wilcoxon test",
"four-center study",
"viable tumor volume",
"non-invasive procedure",
"pain scores",
"adverse events",
"common complication",
"initial treatment",
"MethodsFifteen patients",
"multicenter study",
"preliminary efficacy",
"focused ultrasound treatment",
"median reduction",
"median decrease",
"efficacy threshold",
"tumor growth",
"tumors",
"patients",
"Rating Scale",
"MRgFUS treatment",
"MRgFUS",
"durable control",
"multiple treatments",
"skin burns",
"treatment",
"pain",
"fibromatosis",
"focused ultrasound",
"efficacy",
"complications",
"surgery",
"desmoids",
"ObjectivesTo",
"ultrasound",
"volume",
"ultrasound treatment",
"scores",
"study",
"burns",
"test",
"safety",
"retrospective",
"threshold",
"decrease",
"control",
"events",
"reduction",
"procedure",
"changes",
"feasibility",
"scale",
"series",
"growth",
"radiation",
"point"
],
"name": "Magnetic resonance-guided focused ultrasound treatment of extra-abdominal desmoid tumors: a retrospective multicenter study",
"pagination": "732-740",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1052956088"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00330-016-4376-5"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"27147222"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00330-016-4376-5",
"https://app.dimensions.ai/details/publication/pub.1052956088"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:32",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_698.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00330-016-4376-5"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00330-016-4376-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00330-016-4376-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00330-016-4376-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00330-016-4376-5'
This table displays all metadata directly associated to this object as RDF triples.
361 TRIPLES
22 PREDICATES
120 URIs
104 LITERALS
25 BLANK NODES