Diffusion weighted imaging in cystic fibrosis disease: beyond morphological imaging View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11

AUTHORS

Pierluigi Ciet, Goffredo Serra, Eleni Rosalina Andrinopoulou, Silvia Bertolo, Mirco Ros, Carlo Catalano, Stefano Colagrande, Harm A. W. M. Tiddens, Giovanni Morana

ABSTRACT

OBJECTIVES: To explore the feasibility of diffusion-weighted imaging (DWI) to assess inflammatory lung changes in patients with Cystic Fibrosis (CF) METHODS: CF patients referred for their annual check-up had spirometry, chest-CT and MRI on the same day. MRI was performed in a 1.5 T scanner with BLADE and EPI-DWI sequences (b = 0-600 s/mm2). End-inspiratory and end-expiratory scans were acquired in multi-row scanners. DWI was scored with an established semi-quantitative scoring system. DWI score was correlated to CT sub-scores for bronchiectasis (CF-CTBE), mucus (CF-CTmucus), total score (CF-CTtotal-score), FEV1, and BMI. T-test was used to assess differences between patients with and without DWI-hotspots. RESULTS: Thirty-three CF patients were enrolled (mean 21 years, range 6-51, 19 female). 4 % (SD 2.6, range 1.5-12.9) of total CF-CT alterations presented DWI-hotspots. DWI-hotspots coincided with mucus plugging (60 %), consolidation (30 %) and bronchiectasis (10 %). DWItotal-score correlated (all p < 0.0001) positively to CF-CTBE (r = 0.757), CF-CTmucus (r = 0.759) and CF-CTtotal-score (r = 0.79); and negatively to FEV1 (r = 0.688). FEV1 was significantly higher (p < 0.0001) in patients without DWI-hotspots. CONCLUSIONS: DWI-hotspots strongly correlated with radiological and clinical parameters of lung disease severity. Future validation studies are needed to establish the exact nature of DWI-hotspots in CF patients. KEY POINTS: • DWI hotspots only partly overlapped structural abnormalities on morphological imaging • DWI strongly correlated with radiological and clinical indicators of CF-disease severity • Patients with more DWI hotspots had lower lung function values • Mucus score best predicted the presence of DWI-hotspots with restricted diffusion. More... »

PAGES

3830-3839

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-016-4248-z

DOI

http://dx.doi.org/10.1007/s00330-016-4248-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006498412

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26873494


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    "description": "OBJECTIVES: To explore the feasibility of diffusion-weighted imaging (DWI) to assess inflammatory lung changes in patients with Cystic Fibrosis (CF) METHODS: CF patients referred for their annual check-up had spirometry, chest-CT and MRI on the same day. MRI was performed in a 1.5\u00a0T scanner with BLADE and EPI-DWI sequences (b\u2009=\u20090-600\u00a0s/mm2). End-inspiratory and end-expiratory scans were acquired in multi-row scanners. DWI was scored with an established semi-quantitative scoring system. DWI score was correlated to CT sub-scores for bronchiectasis (CF-CTBE), mucus (CF-CTmucus), total score (CF-CTtotal-score), FEV1, and BMI. T-test was used to assess differences between patients with and without DWI-hotspots.\nRESULTS: Thirty-three CF patients were enrolled (mean 21\u00a0years, range 6-51, 19 female). 4\u00a0% (SD 2.6, range 1.5-12.9) of total CF-CT alterations presented DWI-hotspots. DWI-hotspots coincided with mucus plugging (60\u00a0%), consolidation (30\u00a0%) and bronchiectasis (10\u00a0%). DWItotal-score correlated (all p\u2009<\u20090.0001) positively to CF-CTBE (r\u2009=\u20090.757), CF-CTmucus (r\u2009=\u20090.759) and CF-CTtotal-score (r\u2009=\u20090.79); and negatively to FEV1 (r\u2009=\u20090.688). FEV1 was significantly higher (p\u2009<\u20090.0001) in patients without DWI-hotspots.\nCONCLUSIONS: DWI-hotspots strongly correlated with radiological and clinical parameters of lung disease severity. Future validation studies are needed to establish the exact nature of DWI-hotspots in CF patients.\nKEY POINTS: \u2022 DWI hotspots only partly overlapped structural abnormalities on morphological imaging \u2022 DWI strongly correlated with radiological and clinical indicators of CF-disease severity \u2022 Patients with more DWI hotspots had lower lung function values \u2022 Mucus score best predicted the presence of DWI-hotspots with restricted diffusion.", 
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