Whole brain functional connectivity in clinically isolated syndrome without conventional brain MRI lesions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12-29

AUTHORS

Yaou Liu, Zhengjia Dai, Yunyun Duan, Jing Huang, Zhuoqiong Ren, Zheng Liu, Huiqing Dong, Ni Shu, Hugo Vrenken, Mike P. Wattjes, Frederik Barkhof, Yong He, Kuncheng Li

ABSTRACT

ObjectiveTo investigate brain functional connectivity (FC) alterations in patients with clinically isolated syndromes (CIS) presenting without conventional brain MRI lesions, and to identify the FC differences between the CIS patients who converted to multiple sclerosis (MS) and those not converted during a 5-year follow-up.MethodsWe recruited 20 CIS patients without conventional brain lesions, 28 patients with MS and 28 healthy controls (HC). Normalized voxel-based functional connectivity strength (nFCS) was determined using resting-state fMRI (R-fMRI) and compared among groups. Furthermore, 5-years clinical follow-up of the CIS patients was performed to examine the differences in nFCS between converters and non-converters.ResultsCompared to HC, CIS patients showed significantly decreased nFCS in the visual areas and increased nFCS in several brain regions predominately in the temporal lobes. MS patients revealed more widespread higher nFCS especially in deep grey matter (DGM), compared to CIS and HC. In the four CIS patients converting to MS, significantly higher nFCS was found in right anterior cingulate gyrus (ACC) and fusiform gyrus (FG), compared to non-converted patients.ConclusionWe demonstrated both functional impairment and compensation in CIS by R-fMRI. nFCS alteration in ACC and FG seems to occur in CIS patients at risk of developing MS.Key Points• Both functional impairment and compensation occur in CIS without conventional brain lesions.• MS patients revealed more widespread higher nFCS especially in deep grey matter.• nFCS alteration may help stratifying CIS at risk of developing MS. More... »

PAGES

2982-2991

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-015-4147-8

DOI

http://dx.doi.org/10.1007/s00330-015-4147-8

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https://app.dimensions.ai/details/publication/pub.1020814954

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26714968


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56 fMRI
57 functional connectivity
58 functional connectivity alterations
59 functional connectivity strength
60 functional impairment
61 fusiform gyrus
62 gray matter
63 group
64 gyrus
65 healthy controls
66 impairment
67 lesions
68 lobe
69 matter
70 multiple sclerosis
71 non-converted patients
72 occurs
73 patients
74 region
75 resting-state fMRI
76 right anterior cingulate gyrus
77 risk
78 rs-fMRI
79 sclerosis
80 strength
81 syndrome
82 temporal lobe
83 visual areas
84 whole-brain functional connectivity
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