Dual-energy CT-based iodine quantification for differentiating pulmonary artery sarcoma from pulmonary thromboembolism: a pilot study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12-05

AUTHORS

Suyon Chang, Jin Hur, Dong Jin Im, Young Joo Suh, Yoo Jin Hong, Hye-Jeong Lee, Young Jin Kim, Byoung Wook Choi

ABSTRACT

ObjectivesThe purpose of this study was to determine whether dual-energy computed tomography (DECT) angiography could differentiate pulmonary thromboembolism (PTE) from pulmonary artery sarcoma (PAS).MethodsWe prospectively enrolled 19 patients that had a filling defect in the main pulmonary artery on DECT. Six patients who had PAS and underwent DECT were retrospectively enrolled for comparison. Pathological results or follow-up CT after anticoagulation therapy were used to make the final diagnosis. Two investigators measured the following parameters at the filling defect in the main pulmonary artery: CT attenuation density [Hounsfield units (HU)], iodine-related HU (IHU) and iodine concentration (IC, mg/ml).ResultsFrom a total of 25 patients (M:F = 10:15; mean age, 65 years old), 19 were categorised into the PTE group and six were categorised into the PAS group. The mean HU values were not significantly different between the PTE and PAS groups (45.5 ± 15.9 vs 47.1 ± 9.2 HU; P = 0.776). However, the mean IHU and IC values of the lesions were significantly different between the PTE and PAS groups (10.6 ± 7.2 vs 27.9 ± 9.1 HU; P = 0.004, and 0.61 ± 0.39 vs 1.49 ± 0.57; P = 0.001).ConclusionsDECT angiography using a quantitative analytic methodology can be used to differentiate PTE and PAS.Key Points• DECT can be useful for differentiation of PAS and PTE.• With quantitative analysis, DECT offers tissue characterisation by detecting lesion parameter increases.• The patients without predisposing factors for PTE can be candidates for DECT. More... »

PAGES

3162-3170

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-015-4140-2

DOI

http://dx.doi.org/10.1007/s00330-015-4140-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029463645

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26638163


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