Persistent pulmonary subsolid nodules with solid portions of 5 mm or smaller: Their natural course and predictors of interval growth View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-06

AUTHORS

Jong Hyuk Lee, Chang Min Park, Sang Min Lee, Hyungjin Kim, H. Page McAdams, Jin Mo Goo

ABSTRACT

OBJECTIVE: To investigate the natural course of persistent pulmonary subsolid nodules (SSNs) with solid portions ≤5 mm and the clinico-radiological features that influence interval growth over follow-ups. METHODS: From 2005 to 2013, the natural courses of 213 persistent SSNs in 213 patients were evaluated. To identify significant predictors of interval growth, Kaplan-Meier analysis and Cox proportional hazard regression analysis were performed. RESULTS: Among the 213 nodules, 136 were pure ground-glass nodules (GGNs; growth, 18; stable, 118) and 77 were part-solid GGNs with solid portions ≤5 mm (growth, 24; stable, 53). For all SSNs, lung cancer history (p = 0.001), part-solid GGNs (p < 0.001), and nodule diameter (p < 0.001) were significant predictors for interval growth. On subgroup analysis, nodule diameter was an independent predictor for the interval growth of both pure GGNs (p < 0.001), and part-solid GGNs (p = 0.037). For part-solid GGNs, lung cancer history (p = 0.002) was another significant predictor of the interval growth. Interval growth of pure GGNs ≥10 mm and part-solid GGNs ≥8 mm were significantly more frequent than in pure GGNs <10 mm (p < 0.001) and part-solid GGNs <8 mm (p = 0.003), respectively. CONCLUSION: The natural course of SSNs with solid portions ≤5 mm differed significantly according to their nodule type and nodule diameters, with which their management can be subdivided. KEY POINTS: • Pure GGNs ≥10 mm have significantly more frequent interval growth than those <10 mm. • Part-solid GGNs ≥8 mm have significantly more frequent interval growth than those <8 mm. • Management of SSNs with solid portions ≤5 mm can be subdivided by diameter. More... »

PAGES

1529-1537

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-015-4017-4

DOI

http://dx.doi.org/10.1007/s00330-015-4017-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009778628

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26385803


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    "description": "OBJECTIVE: To investigate the natural course of persistent pulmonary subsolid nodules (SSNs) with solid portions \u22645\u00a0mm and the clinico-radiological features that influence interval growth over follow-ups.\nMETHODS: From 2005 to 2013, the natural courses of 213 persistent SSNs in 213 patients were evaluated. To identify significant predictors of interval growth, Kaplan-Meier analysis and Cox proportional hazard regression analysis were performed.\nRESULTS: Among the 213 nodules, 136 were pure ground-glass nodules (GGNs; growth, 18; stable, 118) and 77 were part-solid GGNs with solid portions \u22645\u00a0mm (growth, 24; stable, 53). For all SSNs, lung cancer history (p\u2009=\u20090.001), part-solid GGNs (p\u2009<\u20090.001), and nodule diameter (p\u2009<\u20090.001) were significant predictors for interval growth. On subgroup analysis, nodule diameter was an independent predictor for the interval growth of both pure GGNs (p\u2009<\u20090.001), and part-solid GGNs (p\u2009=\u20090.037). For part-solid GGNs, lung cancer history (p\u2009=\u20090.002) was another significant predictor of the interval growth. Interval growth of pure GGNs \u226510\u00a0mm and part-solid GGNs \u22658\u00a0mm were significantly more frequent than in pure GGNs <10\u00a0mm (p\u2009<\u20090.001) and part-solid GGNs <8\u00a0mm (p\u2009=\u20090.003), respectively.\nCONCLUSION: The natural course of SSNs with solid portions \u22645\u00a0mm differed significantly according to their nodule type and nodule diameters, with which their management can be subdivided.\nKEY POINTS: \u2022 Pure GGNs \u226510\u00a0mm have significantly more frequent interval growth than those <10\u00a0mm. \u2022 Part-solid GGNs \u22658\u00a0mm have significantly more frequent interval growth than those <8\u00a0mm. \u2022 Management of SSNs with solid portions \u22645\u00a0mm can be subdivided by diameter.", 
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48 schema:description OBJECTIVE: To investigate the natural course of persistent pulmonary subsolid nodules (SSNs) with solid portions ≤5 mm and the clinico-radiological features that influence interval growth over follow-ups. METHODS: From 2005 to 2013, the natural courses of 213 persistent SSNs in 213 patients were evaluated. To identify significant predictors of interval growth, Kaplan-Meier analysis and Cox proportional hazard regression analysis were performed. RESULTS: Among the 213 nodules, 136 were pure ground-glass nodules (GGNs; growth, 18; stable, 118) and 77 were part-solid GGNs with solid portions ≤5 mm (growth, 24; stable, 53). For all SSNs, lung cancer history (p = 0.001), part-solid GGNs (p < 0.001), and nodule diameter (p < 0.001) were significant predictors for interval growth. On subgroup analysis, nodule diameter was an independent predictor for the interval growth of both pure GGNs (p < 0.001), and part-solid GGNs (p = 0.037). For part-solid GGNs, lung cancer history (p = 0.002) was another significant predictor of the interval growth. Interval growth of pure GGNs ≥10 mm and part-solid GGNs ≥8 mm were significantly more frequent than in pure GGNs <10 mm (p < 0.001) and part-solid GGNs <8 mm (p = 0.003), respectively. CONCLUSION: The natural course of SSNs with solid portions ≤5 mm differed significantly according to their nodule type and nodule diameters, with which their management can be subdivided. KEY POINTS: • Pure GGNs ≥10 mm have significantly more frequent interval growth than those <10 mm. • Part-solid GGNs ≥8 mm have significantly more frequent interval growth than those <8 mm. • Management of SSNs with solid portions ≤5 mm can be subdivided by diameter.
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