Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT View Full Text


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Article Info

DATE

2015-05-30

AUTHORS

Pierluigi Ciet, Goffredo Serra, Silvia Bertolo, Sandra Spronk, Mirco Ros, Francesco Fraioli, Serena Quattrucci, M. Baroukh Assael, Carlo Catalano, Fabio Pomerri, Harm. A. W. M Tiddens, Giovanni Morana

ABSTRACT

ObjectivesTo date, PROPELLER MRI, a breathing-motion-insensitive technique, has not been assessed for cystic fibrosis (CF) lung disease. We compared this technique to CT for assessing CF lung disease in children and adults.MethodsThirty-eight stable CF patients (median 21 years, range 6-51 years, 22 female) underwent MRI and CT on the same day. Study protocol included respiratory-triggered PROPELLER MRI and volumetric CT end-inspiratory and -expiratory acquisitions. Two observers scored the images using the CF-MRI and CF-CT systems. Scores were compared with intra-class correlation coefficient (ICC) and Bland-Altman plots. The sensitivity and specificity of MRI versus CT were calculated.ResultsMRI sensitivity for detecting severe CF bronchiectasis was 0.33 (CI 0.09-0.57), while specificity was 100 % (CI 0.88-1). ICCs for bronchiectasis and trapped air were as follows: MRI-bronchiectasis (0.79); CT-bronchiectasis (0.85); MRI-trapped air (0.51); CT-trapped air (0.87). Bland-Altman plots showed an MRI tendency to overestimate the severity of bronchiectasis in mild CF disease and underestimate bronchiectasis in severe disease.ConclusionsMotion correction in PROPELLER MRI does not improve assessment of CF lung disease compared to CT. However, the good inter- and intra-observer agreement and the high specificity suggest that MRI might play a role in the short-term follow-up of CF lung disease (i.e. pulmonary exacerbations).Key Points• PROPELLER MRI does not match CT sensitivity to assess CF lung disease.• PROPELLER MRI has lower sensitivity than CT to detect severe bronchiectasis.• PROPELLER MRI has good to very good intra- and inter-observer variability.• PROPELLER MRI can be used for short-term follow-up studies in CF. More... »

PAGES

780-787

References to SciGraph publications

  • 2012-02-13. MRI of the lung (2/3). Why … when … how? in INSIGHTS INTO IMAGING
  • 2014-08-28. What did we learn from two decades of chest computed tomography in cystic fibrosis? in PEDIATRIC RADIOLOGY
  • 2006-08-29. Proton MRI appearance of cystic fibrosis: Comparison to CT in EUROPEAN RADIOLOGY
  • 2008-05-10. Can lung MR replace lung CT? in PEDIATRIC RADIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00330-015-3850-9

    DOI

    http://dx.doi.org/10.1007/s00330-015-3850-9

    DIMENSIONS

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    https://www.ncbi.nlm.nih.gov/pubmed/26024847


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        "description": "ObjectivesTo date, PROPELLER MRI, a breathing-motion-insensitive technique, has not been assessed for cystic fibrosis (CF) lung disease. We compared this technique to CT for assessing CF lung disease in children and adults.MethodsThirty-eight stable CF patients (median 21\u00a0years, range 6-51 years, 22 female) underwent MRI and CT on the same day. Study protocol included respiratory-triggered PROPELLER MRI and volumetric CT end-inspiratory and -expiratory acquisitions. Two observers scored the images using the CF-MRI and CF-CT systems. Scores were compared with intra-class correlation coefficient (ICC) and Bland-Altman plots. The sensitivity and specificity of MRI versus CT were calculated.ResultsMRI sensitivity for detecting severe CF bronchiectasis was 0.33 (CI 0.09-0.57), while specificity was 100\u00a0% (CI 0.88-1). ICCs for bronchiectasis and trapped air were as follows: MRI-bronchiectasis (0.79); CT-bronchiectasis (0.85); MRI-trapped air (0.51); CT-trapped air (0.87). Bland-Altman plots showed an MRI tendency to overestimate the severity of bronchiectasis in mild CF disease and underestimate bronchiectasis in severe disease.ConclusionsMotion correction in PROPELLER MRI does not improve assessment of CF lung disease compared to CT. However, the good inter- and intra-observer agreement and the high specificity suggest that MRI might play a role in the short-term follow-up of CF lung disease (i.e. pulmonary exacerbations).Key Points\u2022 PROPELLER MRI does not match CT sensitivity to assess CF lung disease.\u2022 PROPELLER MRI has lower sensitivity than CT to detect severe bronchiectasis.\u2022 PROPELLER MRI has good to very good intra- and inter-observer variability.\u2022 PROPELLER MRI can be used for short-term follow-up studies in CF.", 
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    27 schema:description ObjectivesTo date, PROPELLER MRI, a breathing-motion-insensitive technique, has not been assessed for cystic fibrosis (CF) lung disease. We compared this technique to CT for assessing CF lung disease in children and adults.MethodsThirty-eight stable CF patients (median 21 years, range 6-51 years, 22 female) underwent MRI and CT on the same day. Study protocol included respiratory-triggered PROPELLER MRI and volumetric CT end-inspiratory and -expiratory acquisitions. Two observers scored the images using the CF-MRI and CF-CT systems. Scores were compared with intra-class correlation coefficient (ICC) and Bland-Altman plots. The sensitivity and specificity of MRI versus CT were calculated.ResultsMRI sensitivity for detecting severe CF bronchiectasis was 0.33 (CI 0.09-0.57), while specificity was 100 % (CI 0.88-1). ICCs for bronchiectasis and trapped air were as follows: MRI-bronchiectasis (0.79); CT-bronchiectasis (0.85); MRI-trapped air (0.51); CT-trapped air (0.87). Bland-Altman plots showed an MRI tendency to overestimate the severity of bronchiectasis in mild CF disease and underestimate bronchiectasis in severe disease.ConclusionsMotion correction in PROPELLER MRI does not improve assessment of CF lung disease compared to CT. However, the good inter- and intra-observer agreement and the high specificity suggest that MRI might play a role in the short-term follow-up of CF lung disease (i.e. pulmonary exacerbations).Key Points• PROPELLER MRI does not match CT sensitivity to assess CF lung disease.• PROPELLER MRI has lower sensitivity than CT to detect severe bronchiectasis.• PROPELLER MRI has good to very good intra- and inter-observer variability.• PROPELLER MRI can be used for short-term follow-up studies in CF.
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    34 schema:keywords Bland-Altman plots
    35 CF
    36 CF bronchiectasis
    37 CF disease
    38 CF lung disease
    39 CF patients
    40 CF-CT systems
    41 CF-MRI
    42 CT
    43 CT sensitivity
    44 ConclusionsMotion correction
    45 MRI
    46 MRI tendency
    47 MRI-bronchiectasis
    48 MethodsThirty
    49 ObjectivesTo date
    50 PROPELLER MRI
    51 ResultsMRI sensitivity
    52 acquisition
    53 adults
    54 agreement
    55 air
    56 assessment
    57 bronchiectasis
    58 children
    59 coefficient
    60 comparison
    61 correction
    62 correlation coefficient
    63 cystic fibrosis lung disease
    64 date
    65 days
    66 disease
    67 fibrosis (CF) lung disease
    68 follow
    69 good inter
    70 good intra
    71 high specificity
    72 images
    73 insensitive technique
    74 inter
    75 inter-observer variability
    76 intra
    77 intra-class correlation coefficient
    78 intra-observer agreement
    79 low sensitivity
    80 lung disease
    81 mild CF disease
    82 motion
    83 observers
    84 patients
    85 plots
    86 protocol
    87 respiratory-triggered PROPELLER MRI
    88 role
    89 same day
    90 scores
    91 sensitivity
    92 severe CF bronchiectasis
    93 severe bronchiectasis
    94 severe disease
    95 severity
    96 severity of bronchiectasis
    97 short-term follow
    98 specificity
    99 specificity of MRI
    100 stable CF patients
    101 study
    102 study protocol
    103 system
    104 technique
    105 tendency
    106 underestimate bronchiectasis
    107 variability
    108 volumetric CT
    109 schema:name Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT
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