Visual assessment of early emphysema and interstitial abnormalities on CT is useful in lung cancer risk analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05-09

AUTHORS

Mathilde M. W. Wille, Laura H. Thomsen, Jens Petersen, Marleen de Bruijne, Asger Dirksen, Jesper H. Pedersen, Saher B. Shaker

ABSTRACT

ObjectivesScreening for lung cancer should be limited to a high-risk-population, and abnormalities in low-dose computed tomography (CT) screening images may be relevant for predicting the risk of lung cancer. Our aims were to compare the occurrence of visually detected emphysema and interstitial abnormalities in subjects with and without lung cancer in a screening population of smokers.MethodsLow-dose chest CT examinations (baseline and latest possible) of 1990 participants from The Danish Lung Cancer Screening Trial were independently evaluated by two observers who scored emphysema and interstitial abnormalities. Emphysema (lung density) was also measured quantitatively.ResultsEmphysema was seen more frequently and its extent was greater among participants with lung cancer on baseline (odds ratio (OR), 1.8, p = 0.017 and p = 0.002) and late examinations (OR 2.6, p < 0.001 and p < 0.001). No significant difference was found using quantitative measurements. Interstitial abnormalities were more common findings among participants with lung cancer (OR 5.1, p < 0.001 and OR 4.5, p < 0.001).There was no association between presence of emphysema and presence of interstitial abnormalities (OR 0.75, p = 0.499).ConclusionsEven early signs of emphysema and interstitial abnormalities are associated with lung cancer. Quantitative measurements of emphysema—regardless of type—do not show the same association.Key Points• Visually detected emphysema on CT is more frequent in individuals who develop lung cancer.• Emphysema grading is higher in those who develop lung cancer.• Interstitial abnormalities, including discrete changes, are associated with lung cancer.• Quantitative lung density measurements are not useful in lung cancer risk prediction.• Early CT signs of emphysema and interstitial abnormalities can predict future risk. More... »

PAGES

487-494

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-015-3826-9

DOI

http://dx.doi.org/10.1007/s00330-015-3826-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027721779

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25956938


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