Evaluation of MR imaging with T1 and T2* mapping for the determination of hepatic iron overload View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-05-30

AUTHORS

B. Henninger, C. Kremser, S. Rauch, R. Eder, H. Zoller, A. Finkenstedt, H. J. Michaely, M. Schocke

ABSTRACT

ObjectivesTo evaluate MRI using T1 and T2* mapping sequences in patients with suspected hepatic iron overload (HIO).MethodsTwenty-five consecutive patients with clinically suspected HIO were retrospectively studied. All underwent MRI and liver biopsy. For the quantification of liver T2* values we used a fat-saturated multi-echo gradient echo sequence with 12 echoes (TR = 200 ms, TE = 0.99 ms + n × 1.41 ms, flip angle 20°). T1 values were obtained using a fast T1 mapping sequence based on an inversion recovery snapshot FLASH sequence. Parameter maps were analysed using regions of interest.ResultsROC analysis calculated cut-off points at 10.07 ms and 15.47 ms for T2* in the determination of HIO with accuracy 88 %/88 %, sensitivity 84 %/89.5 % and specificity 100 %/83 %. MRI correctly classified 20 patients (80 %). All patients with HIO only had decreased T1 and T2* relaxation times. There was a significant difference in T1 between patients with HIO only and patients with HIO and steatohepatitis (P = 0.018).ConclusionsMRI-based T2* relaxation diagnoses HIO very accurately, even at low iron concentrations. Important additional information may be obtained by the combination of T1 and T2* mapping. It is a rapid, non-invasive, accurate and reproducible technique for validating the evidence of even low hepatic iron concentrations.Key Points• Hepatic iron overload causes fibrosis, cirrhosis and increases hepatocellular carcinoma risk.• MRI detects iron because of the field heterogeneity generated by haemosiderin.• T2* relaxation is very accurate in diagnosing hepatic iron overload.• Additional information may be obtained by T1 and T2* mapping. More... »

PAGES

2478-2486

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-012-2506-2

DOI

http://dx.doi.org/10.1007/s00330-012-2506-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020522015

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22645044


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biopsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemochromatosis Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histocompatibility Antigens Class I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Image Processing, Computer-Assisted", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Iron Overload", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ROC Curve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria", 
          "id": "http://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Radiology, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henninger", 
        "givenName": "B.", 
        "id": "sg:person.0755772617.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755772617.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria", 
          "id": "http://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Radiology, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kremser", 
        "givenName": "C.", 
        "id": "sg:person.0660266326.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660266326.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria", 
          "id": "http://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Radiology, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rauch", 
        "givenName": "S.", 
        "id": "sg:person.01276766444.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276766444.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria", 
          "id": "http://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Radiology, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eder", 
        "givenName": "R.", 
        "id": "sg:person.01345101644.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345101644.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria", 
          "id": "http://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Internal Medicine, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zoller", 
        "givenName": "H.", 
        "id": "sg:person.01074611154.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074611154.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria", 
          "id": "http://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Internal Medicine, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Finkenstedt", 
        "givenName": "A.", 
        "id": "sg:person.0742601113.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742601113.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim \u2013 Heidelberg University, Mannheim, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411778.c", 
          "name": [
            "Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim \u2013 Heidelberg University, Mannheim, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michaely", 
        "givenName": "H. J.", 
        "id": "sg:person.01364214416.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364214416.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria", 
          "id": "http://www.grid.ac/institutes/grid.5361.1", 
          "name": [
            "Department of Radiology, Innsbruck Medical University, Anichstra\u00dfe 35, 6020, Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schocke", 
        "givenName": "M.", 
        "id": "sg:person.015576044104.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576044104.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1111/j.1572-0241.2001.03472.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010957477", 
          "https://doi.org/10.1111/j.1572-0241.2001.03472.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-010-1899-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051544141", 
          "https://doi.org/10.1007/s00330-010-1899-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-05-30", 
    "datePublishedReg": "2012-05-30", 
    "description": "ObjectivesTo evaluate MRI using T1 and T2* mapping sequences in patients with suspected hepatic iron overload (HIO).MethodsTwenty-five consecutive patients with clinically suspected HIO were retrospectively studied. All underwent MRI and liver biopsy. For the quantification of liver T2* values we used a fat-saturated multi-echo gradient echo sequence with 12 echoes (TR\u2009=\u2009200\u00a0ms, TE\u2009=\u20090.99\u00a0ms\u2009+\u2009 n\u2009\u00d7\u20091.41\u00a0ms, flip angle 20\u00b0). T1 values were obtained using a fast T1 mapping sequence based on an inversion recovery snapshot FLASH sequence. Parameter maps were analysed using regions of interest.ResultsROC analysis calculated cut-off points at 10.07\u00a0ms and 15.47\u00a0ms for T2* in the determination of HIO with accuracy 88\u00a0%/88\u00a0%, sensitivity 84\u00a0%/89.5\u00a0% and specificity 100\u00a0%/83\u00a0%. MRI correctly classified 20 patients (80\u00a0%). All patients with HIO only had decreased T1 and T2* relaxation times. There was a significant difference in T1 between patients with HIO only and patients with HIO and steatohepatitis (P\u2009=\u20090.018).ConclusionsMRI-based T2* relaxation diagnoses HIO very accurately, even at low iron concentrations. Important additional information may be obtained by the combination of T1 and T2* mapping. It is a rapid, non-invasive, accurate and reproducible technique for validating the evidence of even low hepatic iron concentrations.Key Points\u2022 Hepatic iron overload causes fibrosis, cirrhosis and increases hepatocellular carcinoma risk.\u2022 MRI detects iron because of the field heterogeneity generated by haemosiderin.\u2022 T2* relaxation is very accurate in diagnosing hepatic iron overload.\u2022 Additional information may be obtained by T1 and T2* mapping.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00330-012-2506-2", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1289120", 
        "issn": [
          "0938-7994", 
          "1432-1084"
        ], 
        "name": "European Radiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "keywords": [
      "hepatic iron overload", 
      "iron overload", 
      "MethodsTwenty-five consecutive patients", 
      "hepatic iron concentration", 
      "hepatocellular carcinoma risk", 
      "consecutive patients", 
      "liver biopsy", 
      "carcinoma risk", 
      "patients", 
      "liver T2", 
      "specificity 100", 
      "sensitivity 84", 
      "ResultsROC analysis", 
      "gradient echo sequence", 
      "T1 mapping sequences", 
      "important additional information", 
      "evaluation of MR", 
      "MRI", 
      "accuracy 88", 
      "reproducible technique", 
      "significant differences", 
      "iron concentration", 
      "combination of T1", 
      "mapping sequence", 
      "overload", 
      "multi-echo gradient-echo sequence", 
      "echo sequence", 
      "T2", 
      "additional information", 
      "T1", 
      "FLASH sequence", 
      "steatohepatitis", 
      "cirrhosis", 
      "ConclusionsMRI", 
      "biopsy", 
      "region of interest", 
      "fibrosis", 
      "ObjectivesTo", 
      "T1 values", 
      "haemosiderin", 
      "risk", 
      "snapshot FLASH sequence", 
      "ms", 
      "MR", 
      "concentration", 
      "evidence", 
      "differences", 
      "evaluation", 
      "parameter maps", 
      "low iron concentrations", 
      "heterogeneity", 
      "combination", 
      "information", 
      "relaxation", 
      "values", 
      "quantification", 
      "time", 
      "analysis", 
      "sequence", 
      "echoes", 
      "determination", 
      "region", 
      "iron", 
      "mapping", 
      "technique", 
      "point", 
      "interest", 
      "relaxation time", 
      "maps", 
      "field heterogeneity"
    ], 
    "name": "Evaluation of MR imaging with T1 and T2* mapping for the determination of hepatic iron overload", 
    "pagination": "2478-2486", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020522015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00330-012-2506-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22645044"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00330-012-2506-2", 
      "https://app.dimensions.ai/details/publication/pub.1020522015"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_585.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00330-012-2506-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00330-012-2506-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00330-012-2506-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00330-012-2506-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00330-012-2506-2'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      21 PREDICATES      116 URIs      106 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00330-012-2506-2 schema:about N153af47954f54c3d9e5c8c313d561c86
2 N1a1c2893bb73471298faa525bf5b3b4b
3 N2d62acc7e5b842f9b1c31fa958ecffc0
4 N34c0a11e653b4a7c8403b023d62d304c
5 N3d2b829cb4834170a6416301d562458f
6 N3fcd4b921bef4046a1dfce5ff0028e2c
7 N484c3c5d0f384e9481ed3e3af0b8b034
8 N5435b64911ae41db90c5e35f1464f0f6
9 N5a3c5124f21d41f8b5426543590be700
10 N6e51151f474c4f5baebdfc4e6693523e
11 N956af73578a64811b7bfdbffbd751f07
12 N97c5fcfefc644f2b83257d663a53d8db
13 N9bb63947834b4183bb37502e794473b1
14 Na5ade5a209e44733a9b1639d6e74fa85
15 Nc42f6f93aaf04ef594f90263304e3662
16 Ndfcc1cc8434749c0bfb357b5bc306ce2
17 Ne2e7748116d34a0c9dab446936177da4
18 Nf168ee5f61144ff880f50a50be555ccf
19 Nfcc0e382e2744f06823f6a7431beca6b
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author N8cba2aa49b274118970ff227e7472ec2
23 schema:citation sg:pub.10.1007/s00330-010-1899-z
24 sg:pub.10.1111/j.1572-0241.2001.03472.x
25 schema:datePublished 2012-05-30
26 schema:datePublishedReg 2012-05-30
27 schema:description ObjectivesTo evaluate MRI using T1 and T2* mapping sequences in patients with suspected hepatic iron overload (HIO).MethodsTwenty-five consecutive patients with clinically suspected HIO were retrospectively studied. All underwent MRI and liver biopsy. For the quantification of liver T2* values we used a fat-saturated multi-echo gradient echo sequence with 12 echoes (TR = 200 ms, TE = 0.99 ms +  n × 1.41 ms, flip angle 20°). T1 values were obtained using a fast T1 mapping sequence based on an inversion recovery snapshot FLASH sequence. Parameter maps were analysed using regions of interest.ResultsROC analysis calculated cut-off points at 10.07 ms and 15.47 ms for T2* in the determination of HIO with accuracy 88 %/88 %, sensitivity 84 %/89.5 % and specificity 100 %/83 %. MRI correctly classified 20 patients (80 %). All patients with HIO only had decreased T1 and T2* relaxation times. There was a significant difference in T1 between patients with HIO only and patients with HIO and steatohepatitis (P = 0.018).ConclusionsMRI-based T2* relaxation diagnoses HIO very accurately, even at low iron concentrations. Important additional information may be obtained by the combination of T1 and T2* mapping. It is a rapid, non-invasive, accurate and reproducible technique for validating the evidence of even low hepatic iron concentrations.Key Points• Hepatic iron overload causes fibrosis, cirrhosis and increases hepatocellular carcinoma risk.• MRI detects iron because of the field heterogeneity generated by haemosiderin.• T2* relaxation is very accurate in diagnosing hepatic iron overload.• Additional information may be obtained by T1 and T2* mapping.
28 schema:genre article
29 schema:isAccessibleForFree false
30 schema:isPartOf N5dbea0f3e4054a999ca6992800936b98
31 Ncbfac0f9a88c4d56bb14426c2e98babb
32 sg:journal.1289120
33 schema:keywords ConclusionsMRI
34 FLASH sequence
35 MR
36 MRI
37 MethodsTwenty-five consecutive patients
38 ObjectivesTo
39 ResultsROC analysis
40 T1
41 T1 mapping sequences
42 T1 values
43 T2
44 accuracy 88
45 additional information
46 analysis
47 biopsy
48 carcinoma risk
49 cirrhosis
50 combination
51 combination of T1
52 concentration
53 consecutive patients
54 determination
55 differences
56 echo sequence
57 echoes
58 evaluation
59 evaluation of MR
60 evidence
61 fibrosis
62 field heterogeneity
63 gradient echo sequence
64 haemosiderin
65 hepatic iron concentration
66 hepatic iron overload
67 hepatocellular carcinoma risk
68 heterogeneity
69 important additional information
70 information
71 interest
72 iron
73 iron concentration
74 iron overload
75 liver T2
76 liver biopsy
77 low iron concentrations
78 mapping
79 mapping sequence
80 maps
81 ms
82 multi-echo gradient-echo sequence
83 overload
84 parameter maps
85 patients
86 point
87 quantification
88 region
89 region of interest
90 relaxation
91 relaxation time
92 reproducible technique
93 risk
94 sensitivity 84
95 sequence
96 significant differences
97 snapshot FLASH sequence
98 specificity 100
99 steatohepatitis
100 technique
101 time
102 values
103 schema:name Evaluation of MR imaging with T1 and T2* mapping for the determination of hepatic iron overload
104 schema:pagination 2478-2486
105 schema:productId N597d60bce0bc4d0392b8cd778186d6c4
106 Ndb85ab5521994dd8bc487e483f6a6a3c
107 Ne5f0bf57f1d8489c8f573d2115edb7c4
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020522015
109 https://doi.org/10.1007/s00330-012-2506-2
110 schema:sdDatePublished 2022-09-02T15:56
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher N5381fe5a065b4afb8d5dfb15da98f6bb
113 schema:url https://doi.org/10.1007/s00330-012-2506-2
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N0fc3db5cd240422ba53944de9e440deb rdf:first sg:person.0660266326.16
118 rdf:rest Na3eb9d0ae1e94b9bb3437788066695e2
119 N153af47954f54c3d9e5c8c313d561c86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name ROC Curve
121 rdf:type schema:DefinedTerm
122 N1a1c2893bb73471298faa525bf5b3b4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Retrospective Studies
124 rdf:type schema:DefinedTerm
125 N20f1e507381c4ec5aef94b5d2ec569c7 rdf:first sg:person.01074611154.49
126 rdf:rest N2354ab74f68b473496eb30036f45f096
127 N2354ab74f68b473496eb30036f45f096 rdf:first sg:person.0742601113.72
128 rdf:rest Na1b3f6ae8c6440d09352d78a3680ebec
129 N2d62acc7e5b842f9b1c31fa958ecffc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Reproducibility of Results
131 rdf:type schema:DefinedTerm
132 N34c0a11e653b4a7c8403b023d62d304c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Polymorphism, Genetic
134 rdf:type schema:DefinedTerm
135 N3d2b829cb4834170a6416301d562458f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Hemochromatosis Protein
137 rdf:type schema:DefinedTerm
138 N3fcd4b921bef4046a1dfce5ff0028e2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Middle Aged
140 rdf:type schema:DefinedTerm
141 N484c3c5d0f384e9481ed3e3af0b8b034 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Image Processing, Computer-Assisted
143 rdf:type schema:DefinedTerm
144 N5381fe5a065b4afb8d5dfb15da98f6bb schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N5435b64911ae41db90c5e35f1464f0f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Male
148 rdf:type schema:DefinedTerm
149 N597d60bce0bc4d0392b8cd778186d6c4 schema:name pubmed_id
150 schema:value 22645044
151 rdf:type schema:PropertyValue
152 N5a3c5124f21d41f8b5426543590be700 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Histocompatibility Antigens Class I
154 rdf:type schema:DefinedTerm
155 N5dbea0f3e4054a999ca6992800936b98 schema:issueNumber 11
156 rdf:type schema:PublicationIssue
157 N6e51151f474c4f5baebdfc4e6693523e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Aged
159 rdf:type schema:DefinedTerm
160 N7f825a99f5d84aec895809b1cdf3f99a rdf:first sg:person.015576044104.34
161 rdf:rest rdf:nil
162 N8cba2aa49b274118970ff227e7472ec2 rdf:first sg:person.0755772617.78
163 rdf:rest N0fc3db5cd240422ba53944de9e440deb
164 N956af73578a64811b7bfdbffbd751f07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Iron Overload
166 rdf:type schema:DefinedTerm
167 N97c5fcfefc644f2b83257d663a53d8db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Adult
169 rdf:type schema:DefinedTerm
170 N9bb63947834b4183bb37502e794473b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Female
172 rdf:type schema:DefinedTerm
173 Na1b3f6ae8c6440d09352d78a3680ebec rdf:first sg:person.01364214416.55
174 rdf:rest N7f825a99f5d84aec895809b1cdf3f99a
175 Na3eb9d0ae1e94b9bb3437788066695e2 rdf:first sg:person.01276766444.74
176 rdf:rest Nf7d6ffca9b934c70913d466e7bf48460
177 Na5ade5a209e44733a9b1639d6e74fa85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Biopsy
179 rdf:type schema:DefinedTerm
180 Nc42f6f93aaf04ef594f90263304e3662 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Humans
182 rdf:type schema:DefinedTerm
183 Ncbfac0f9a88c4d56bb14426c2e98babb schema:volumeNumber 22
184 rdf:type schema:PublicationVolume
185 Ndb85ab5521994dd8bc487e483f6a6a3c schema:name doi
186 schema:value 10.1007/s00330-012-2506-2
187 rdf:type schema:PropertyValue
188 Ndfcc1cc8434749c0bfb357b5bc306ce2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Liver
190 rdf:type schema:DefinedTerm
191 Ne2e7748116d34a0c9dab446936177da4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Fatty Liver
193 rdf:type schema:DefinedTerm
194 Ne5f0bf57f1d8489c8f573d2115edb7c4 schema:name dimensions_id
195 schema:value pub.1020522015
196 rdf:type schema:PropertyValue
197 Nf168ee5f61144ff880f50a50be555ccf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Membrane Proteins
199 rdf:type schema:DefinedTerm
200 Nf7d6ffca9b934c70913d466e7bf48460 rdf:first sg:person.01345101644.75
201 rdf:rest N20f1e507381c4ec5aef94b5d2ec569c7
202 Nfcc0e382e2744f06823f6a7431beca6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Magnetic Resonance Imaging
204 rdf:type schema:DefinedTerm
205 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
206 schema:name Medical and Health Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
209 schema:name Clinical Sciences
210 rdf:type schema:DefinedTerm
211 sg:journal.1289120 schema:issn 0938-7994
212 1432-1084
213 schema:name European Radiology
214 schema:publisher Springer Nature
215 rdf:type schema:Periodical
216 sg:person.01074611154.49 schema:affiliation grid-institutes:grid.5361.1
217 schema:familyName Zoller
218 schema:givenName H.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074611154.49
220 rdf:type schema:Person
221 sg:person.01276766444.74 schema:affiliation grid-institutes:grid.5361.1
222 schema:familyName Rauch
223 schema:givenName S.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276766444.74
225 rdf:type schema:Person
226 sg:person.01345101644.75 schema:affiliation grid-institutes:grid.5361.1
227 schema:familyName Eder
228 schema:givenName R.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345101644.75
230 rdf:type schema:Person
231 sg:person.01364214416.55 schema:affiliation grid-institutes:grid.411778.c
232 schema:familyName Michaely
233 schema:givenName H. J.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364214416.55
235 rdf:type schema:Person
236 sg:person.015576044104.34 schema:affiliation grid-institutes:grid.5361.1
237 schema:familyName Schocke
238 schema:givenName M.
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576044104.34
240 rdf:type schema:Person
241 sg:person.0660266326.16 schema:affiliation grid-institutes:grid.5361.1
242 schema:familyName Kremser
243 schema:givenName C.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660266326.16
245 rdf:type schema:Person
246 sg:person.0742601113.72 schema:affiliation grid-institutes:grid.5361.1
247 schema:familyName Finkenstedt
248 schema:givenName A.
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742601113.72
250 rdf:type schema:Person
251 sg:person.0755772617.78 schema:affiliation grid-institutes:grid.5361.1
252 schema:familyName Henninger
253 schema:givenName B.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755772617.78
255 rdf:type schema:Person
256 sg:pub.10.1007/s00330-010-1899-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1051544141
257 https://doi.org/10.1007/s00330-010-1899-z
258 rdf:type schema:CreativeWork
259 sg:pub.10.1111/j.1572-0241.2001.03472.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010957477
260 https://doi.org/10.1111/j.1572-0241.2001.03472.x
261 rdf:type schema:CreativeWork
262 grid-institutes:grid.411778.c schema:alternateName Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim – Heidelberg University, Mannheim, Germany
263 schema:name Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim – Heidelberg University, Mannheim, Germany
264 rdf:type schema:Organization
265 grid-institutes:grid.5361.1 schema:alternateName Department of Internal Medicine, Innsbruck Medical University, Anichstraße 35, 6020, Innsbruck, Austria
266 Department of Radiology, Innsbruck Medical University, Anichstraße 35, 6020, Innsbruck, Austria
267 schema:name Department of Internal Medicine, Innsbruck Medical University, Anichstraße 35, 6020, Innsbruck, Austria
268 Department of Radiology, Innsbruck Medical University, Anichstraße 35, 6020, Innsbruck, Austria
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...