Accuracy of core-needle biopsy after contrast-enhanced ultrasound in soft-tissue tumours View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-11

AUTHORS

Armanda De Marchi, Elena Maria Brach del Prever, Alessandra Linari, Simona Pozza, Lucia Verga, Ugo Albertini, Marco Forni, Gian Carlo Gino, Alessandro Comandone, Adalberto Maria Brach del Prever, Raimondo Piana, Carlo Faletti, Piedmont Sarcoma Group

ABSTRACT

OBJECTIVE: Percutaneous biopsies are gaining acceptance in the diagnosis of soft-tissue tumours. Sampling in the most representative area is not easy in sarcomas of huge dimension. We hypothesised that ultrasound (US) contrast medium could identify the representative area for focus core-needle biopsy (CNB) METHODS: This is a retrospective cohort series of 115 soft-tissue masses treated from January 2007 to November 2008. Accuracy of US-guided CNB after contrast-enhanced US (CEUS) was determined by comparing the histology of the biopsy with the definitive diagnosis in 105 surgically excised samples (42 benign, 63 malignant) and with the expected outcome in the remaining ten malignant cases not surgically treated. A myxoid component was present in 21 sarcomas (34.4%). RESULTS: Of samples, 94.8% were adequate for diagnosis with 97.1% sensitivity and 92.5% specificity. Sensitivity and specificity in specific histopathological subgroupings were 100%, and in grading definition they were 100% and 96.8%. DISCUSSION: US-guided CNB is safe and effective. US contrast medium depicts tumour vascular supply and identifies the representative area(s) for sampling. Sensitivity and specificity are also high in subgrouping and grading, including myxoid types. Discussion about biopsy is part of the essential multidisciplinary strategy for these tumours. More... »

PAGES

2740-2748

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-010-1847-y

DOI

http://dx.doi.org/10.1007/s00330-010-1847-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018673068

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20582701


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