Quantification of renal allograft perfusion using arterial spin labeling MRI: initial results View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-12-01

AUTHORS

Rotem S. Lanzman, Hans-Jörg Wittsack, Petros Martirosian, Panagiota Zgoura, Philip Bilk, Patric Kröpil, Fritz Schick, Adina Voiculescu, Dirk Blondin

ABSTRACT

ObjectiveTo quantify renal allograft perfusion in recipients with stable allograft function and acute decrease in allograft function using nonenhanced flow-sensitive alternating inversion recovery (FAIR)-TrueFISP arterial spin labeling (ASL) MR imaging.MethodsFollowing approval of the local ethics committee, 20 renal allograft recipients were included in this study. ASL perfusion measurement and an anatomical T2-weighted single-shot fast spin-echo (HASTE) sequence were performed on a 1.5-T scanner (Magnetom Avanto, Siemens, Erlangen, Germany). T2-weighted MR urography was performed in patients with suspected ureteral obstruction. Patients were assigned to three groups: group a, 6 patients with stable allograft function over the previous 4 months; group b, 7 patients with good allograft function who underwent transplantation during the previous 3 weeks; group c, 7 allograft recipients with an acute deterioration of renal function.ResultsMean cortical perfusion values were 304.8 ± 34.4, 296.5 ± 44.1, and 181.9 ± 53.4 mg/100 ml/min for groups a, b and c, respectively. Reduction in cortical perfusion in group c was statistically significant.ConclusionOur results indicate that ASL is a promising technique for nonenhanced quantification of cortical perfusion of renal allografts. Further studies are required to determine the clinical value of ASL for monitoring renal allograft recipients. More... »

PAGES

1485-1491

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-009-1675-0

DOI

http://dx.doi.org/10.1007/s00330-009-1675-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023514274

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19949799


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