Prevalence and correlates of pulmonary emphysema in smokers and former smokers. A densitometric study of participants in the ITALUNG trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-01

AUTHORS

Gianna Camiciottoli, Edoardo Cavigli, Luca Grassi, Stefano Diciotti, Ilaria Orlandi, Marco Zappa, Giulia Picozzi, Andrea Lopes Pegna, Eugenio Paci, Fabio Falaschi, Mario Mascalchi

ABSTRACT

We assessed with computed tomography (CT) densitometry the prevalence of emphysema in 266 (175 men and 91 women; mean age 64 +/- 4 years) smokers and former smokers enrolled in the ITALUNG trial of lung cancer screening with low-dose thin-slice CT. Whole-lung volume and the relative area at -950 Hounsfield units (RA(950)) and mean lung attenuation (MLA) in 1 of every 10 slices (mean, 24 slices per subject) were measured. Lung volume, MLA and RA950 significantly correlated each other and with age. Average RA950 >6.8% qualifying for emphysema was present in 71 (26.6%) of 266 subjects, with a higher prevalence in men than in women (30.3% vs 19.8%; p = 0.003). Only in smokers was a weak (r = 0.18; p = 0.05) correlation between RA950 and packs/year observed. In multiple regression analysis, the variability of RA950 (R2 = 0.24) or MLA (R2 = 0.34) was significantly, but weakly explained by age, lung volume and packs/year. Other factors besides smoking may also have a significant role in the etiopathogenesis of pulmonary emphysema. More... »

PAGES

58-66

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-008-1131-6

DOI

http://dx.doi.org/10.1007/s00330-008-1131-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046570451

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18690451


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