Trans-catheter arterial chemoembolization as first-line treatment for hepatic metastases from endocrine tumors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-01

AUTHORS

Alain Roche, Baragur V. Girish, Thierry de Baère, Eric Baudin, Valérie Boige, Dominique Elias, Philippe Lasser, Martin Schlumberger, Michel Ducreux

ABSTRACT

Our objective was to report the outcome in patients with liver metastasis from endocrine tumors who underwent transarterial chemoembolization (TACE) as first-line non-surgical treatment. From January 1990 to December 2000, 14 patients with progressive unresectable liver metastases from digestive neuroendocrine tumor were treated with TACE (mean of 3.6 sessions) before any non-surgical treatment (somatostatin analogue, chemotherapy or interferon). Liver involvement was less than 50% in 11 patients. Size of the largest lesion ranged from 1.5 to 10 cm. Ten patients presented with carcinoid symptoms. The TACE was performed with Doxorubicin emulsified in Lipiodol and gelatin sponge particles. Symptomatic response upon flushes and/or diarrhea was complete in 7 of 10 cases and partial in 2 of 10 cases. An objective morphologic response was noted in 12 of 14 cases. The 5- and 10-year survival rate from diagnosis was 83 and 56%, respectively. Six patients were alive at the end of the study after 27-100 months from first TACE and 38-142 months from diagnosis. Three of them were successfully palliated for 55, 69, and 100 months with only TACE as treatment. Long-term palliation is possible in unresectable liver metastases from digestive neuroendocrine tumors with a few sessions of TACE as first-line and eventually exclusive treatment. More... »

PAGES

136-140

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00330-002-1558-0

DOI

http://dx.doi.org/10.1007/s00330-002-1558-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1075222278

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12541121


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