Plasma fibronectin- and thrombospondin-adhesive molecules during acute attacks and attack-free periods of familial Mediterranean fever View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-05-23

AUTHORS

Ihsan Ertenli, Sedat Kiraz, Akif M. Öztürk, Ibrahim C. Haznedaroglu, Ismail Çelik, Şerafettin Kirazli, Meral Çalgüneri

ABSTRACT

We assessed plasma concentrations of fibronectin (FN) and thrombospondin (TSP) during acute attacks and attack-free periods of patients with familial Mediterranean fever (FMF). Seven female and three male FMF patients (mean age 34±7 years) were enrolled in the study. Plasma samples were obtained during acute FMF attacks and after 3 months of freedom from attacks. Erythrocyte sedimentation rate, C-reactive protein, and white blood cell count were evaluated concurrently. Plasma levels of FN and TSP were assayed by enzyme-linked immunosorbent assay (ELISA). Both FN and TSP concentrations were found to increase during acute attacks. Levels of adhesive molecules decreased during attack-free periods (P<0.05). Significant correlations were found between FN and TSP levels and the concentrations of acute-phase response indicators (P<0.05). This study disclosed for the first time significantly higher increments in the plasma levels of FN and TSP during acute FMF attacks than in attack-free periods. Therefore, the two matrix glycoproteins may play precipitating and/or regulatory roles in the inflammatory processes of these attacks. More... »

PAGES

217-220

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002960100107

DOI

http://dx.doi.org/10.1007/s002960100107

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031570783

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11563578


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