Safety and efficacy of bi-annual intra-articular LBSA0103 injections in patients with knee osteoarthritis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08-22

AUTHORS

Jin Kyu Lee, Chong-Hyuk Choi, Kwang-Jun Oh, Hee-Soo Kyung, Ju-Hyung Yoo, Chul-Won Ha, Seong-Il Bin, Seung-Baik Kang, Myung Ku Kim, Ju-Hong Lee, Myung Chul Lee

ABSTRACT

The objective of this study is to assess the safety and efficacy of repeated intra-articular injection of high molecular weight hyaluronic acid (LBSA0103) at a 26-week interval, in patients with osteoarthritis of the knee. The study was an open-label, single arm, multicentre prospective trial conducted in patients with symptomatic knee osteoarthritis. The intervention consisted of two intra-articular injections of LBSA0103, with the second injection performed 26 weeks after the first injection. The primary outcome was the incidence of adverse drug reactions related to each injection. Assessment of efficacy of repeated injections in terms of maintenance of pain relief was a secondary objective of this study. Of the 185 patients screened, 174 patients received the first injection and 153 patients received both injections of LBSA0103. Nine adverse drug reactions occurred in seven patients (4.02%) after the first injection, while only one adverse drug reaction occurred (0.65%) after the second injection. As a secondary outcome measure, the improvements in the efficacy parameters including total WOMAC score and weight-bearing pain were all significant at both week 13 and 39 compared to the baseline value (P < 0.001), and improvements after the second injection were consistent with those after the initial injection of LBSA0103 (between week 26 and week 39, P < 0.001). Repeated intra-articular injection of LBSA0103 at a 26-week interval is safe without increased risk of adverse drug reactions. Additionally, LBSA0103 is effective in reduction of osteoarthritis knee pain and in maintenance of pain reduction for a 39-week period when a second injection is administered. More... »

PAGES

1807-1815

References to SciGraph publications

Journal

TITLE

Rheumatology International

ISSUE

11

VOLUME

37

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00296-017-3803-5

DOI

http://dx.doi.org/10.1007/s00296-017-3803-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091292374

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28831552


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