IgG4-related disease: a complex under-diagnosed clinical entity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-02

AUTHORS

Sujani Yadlapati, Elijah Verheyen, Petros Efthimiou

ABSTRACT

IgG4-related disease (IgG4-RD) encompasses a spectrum of complex fibro-inflammatory disorders which are often under diagnosed due to unfamiliarity by clinicians. A challenging multitude of clinical manifestations makes the diagnosis cumbersome. The primary clinical feature in IgG4-RD entails a tumor-like presentation coupled with tissue-destructive lesions. Histopathological findings include lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis. These findings, in combination with elevated serum immunoglobulin G4 levels, are diagnostic in the setting of single- or multi-organ involvement. A closer understanding of the role of T cells and B cells in the increased production of IgG4 has led to a notion that IgG4 can act as a pathogen, anti-inflammatory agent, or rheumatoid factor. Glucocorticoids are the primary treatment modality; however, relapse is common with prolonged therapy. Alternatively, immunomodulatory agents are being increasingly used as therapy. The aim of this article is to raise awareness of IgG4-RD and review the diagnostic algorithm, as IgG4-RD often mimics a wide array of clinical conditions. In addition, we summarize the pathogenesis and current treatment guidelines of IgG4-RD for clinicians. Awareness and accurate diagnosis are crucial in preventing progression to chronic diseases, thereby diminishing disease-related morbidity and mortality. More... »

PAGES

169-177

References to SciGraph publications

  • 2013-04. Risk of Cancer in Patients With Autoimmune Pancreatitis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2012-02. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 in MODERN RHEUMATOLOGY
  • 2008-03. Association of Autoimmune Pancreatitis With Cytotoxic T-lymphocyte Antigen 4 Gene Polymorphisms in Japanese Patients in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2010-09. Autoantibodies Against the Exocrine Pancreas in Autoimmune Pancreatitis: Gene and Protein Expression Profiling and Immunoassays Identify Pancreatic Enzymes as a Major Target of the Inflammatory Process in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2014-10. Type 1 Autoimmune Pancreatitis and IgG4-Related Sclerosing Cholangitis Is Associated With Extrapancreatic Organ Failure, Malignancy, and Mortality in a Prospective UK Cohort in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2011-12. Successful treatment of pediatric IgG4 related systemic disease with mycophenolate mofetil: case report and a review of the pediatric autoimmune pancreatitis literature in PEDIATRIC RHEUMATOLOGY
  • 2012-03. Histopathological findings in 29 lymph node biopsies with increased IgG4 plasma cells in MODERN PATHOLOGY
  • 2011-03. Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease in JOURNAL OF GASTROENTEROLOGY
  • 2015-06. IgG4-Associated Cholangitis: A Comprehensive Review in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • 2017-04. Idiopathic retroperitoneal fibrosis and its overlap with IgG4-related disease in INTERNAL AND EMERGENCY MEDICINE
  • 2007-01. Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis in IMMUNOGENETICS
  • 2011-01. Clinical significance of immunoglobulin G4-associated autoimmune hepatitis in JOURNAL OF GASTROENTEROLOGY
  • 2010-11. Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis in KIDNEY INTERNATIONAL
  • 2017-04. Elevated serum IgG4 levels in diagnosis and treatment response in patients with idiopathic retroperitoneal fibrosis in CLINICAL RHEUMATOLOGY
  • 2012-09. Consensus statement on the pathology of IgG4-related disease in MODERN PATHOLOGY
  • 2003-10. A new clinicopathological entity of IgG4-related autoimmune disease in JOURNAL OF GASTROENTEROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00296-017-3765-7

    DOI

    http://dx.doi.org/10.1007/s00296-017-3765-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090358444

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28681251


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Algorithms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Autoimmune Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Autoimmunity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Clinical Decision-Making", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diagnosis, Differential", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fibrosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glucocorticoids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoglobulin G", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunosuppressive Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Predictive Value of Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Albert Einstein Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.239276.b", 
              "name": [
                "Department of Internal Medicine, Albert Einstein Medical Center, Philadelphia, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yadlapati", 
            "givenName": "Sujani", 
            "id": "sg:person.01134620611.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134620611.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Luke's-Roosevelt Hospital Center", 
              "id": "https://www.grid.ac/institutes/grid.240873.a", 
              "name": [
                "Department of Internal Medicine, St. Luke\u2019s-Roosevelt Hospital Center, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Verheyen", 
            "givenName": "Elijah", 
            "id": "sg:person.016170370352.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016170370352.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cornell University", 
              "id": "https://www.grid.ac/institutes/grid.5386.8", 
              "name": [
                "Division of Rheumatology, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA", 
                "Weill Cornell Medical College, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Efthimiou", 
            "givenName": "Petros", 
            "id": "sg:person.01146105417.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146105417.56"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1097/md.0000000000001366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000820271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000001366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000820271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2222.2009.03207.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000911660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semarthrit.2013.11.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001981399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2004.049064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002436536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2012/259408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003894712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/cdli.12.5.632-639.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006214557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12016-014-8430-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006537330", 
              "https://doi.org/10.1007/s12016-014-8430-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2012.465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006914660", 
              "https://doi.org/10.1038/ajg.2012.465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bjd.13296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007324265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2004.047142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007686599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cgh.2009.07.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009666736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2011.177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010123852", 
              "https://doi.org/10.1038/modpathol.2011.177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3960/jslrt.51.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010143029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1007/s10165-011-0508-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012374983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e3283412f7c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013143090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e3283412f7c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013143090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e3283412f7c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013143090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2015/591360", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013289764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2012/139409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014512805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/s10165-011-0571-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015464107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm200103083441005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015560931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2007.01750.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017337415", 
              "https://doi.org/10.1111/j.1572-0241.2007.01750.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1582-4934.2005.tb00506.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017714569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.pas.0000213331.09864.2c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018462014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.pas.0000213331.09864.2c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018462014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-011-0386-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019125874", 
              "https://doi.org/10.1007/s00535-011-0386-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/2050640614532457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019179426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/2050640614532457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019179426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/keq113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019778979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-010-0323-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020994716", 
              "https://doi.org/10.1007/s00535-010-0323-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-010-0323-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020994716", 
              "https://doi.org/10.1007/s00535-010-0323-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2012/572539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021908577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.2010.085613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022600702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e3181342f0d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022618751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e3181342f0d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022618751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1144603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022714329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2012.72", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022783314", 
              "https://doi.org/10.1038/modpathol.2012.72"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.39132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022851625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2012/602809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024171151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.39205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026660595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpa.0b013e31826bef91", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026769188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpa.0b013e31826bef91", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026769188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-pathol-012513-104708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028429359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-pathol-012513-104708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028429359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2014.223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028432816", 
              "https://doi.org/10.1038/ajg.2014.223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2010.141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030977695", 
              "https://doi.org/10.1038/ajg.2010.141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2010.141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030977695", 
              "https://doi.org/10.1038/ajg.2010.141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e328341a240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031335557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e328341a240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031335557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e328341a240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031335557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11739-016-1599-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033520422", 
              "https://doi.org/10.1007/s11739-016-1599-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11739-016-1599-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033520422", 
              "https://doi.org/10.1007/s11739-016-1599-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.2010.271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034572106", 
              "https://doi.org/10.1038/ki.2010.271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2014-205233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034747568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00251-006-0178-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035213611", 
              "https://doi.org/10.1007/s00251-006-0178-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00251-006-0178-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035213611", 
              "https://doi.org/10.1007/s00251-006-0178-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.autrev.2014.08.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035643873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/gast.2002.33022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036172285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra1104650", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037514297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0903068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038004174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10165-011-0571-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039029422", 
              "https://doi.org/10.1007/s10165-011-0571-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e3283412fd4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039834024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e3283412fd4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039834024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e3283412fd4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039834024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mpa.0000226881.48204.fd", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040203359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mpa.0000226881.48204.fd", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040203359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2012/358371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040240254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmcpc1209330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040545877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0001637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041768901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/his.12122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042330264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3348/kjr.2015.16.5.1056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042593716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2006.095059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042682301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1373/clinchem.2007.085951", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043059833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dld.2011.03.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046414691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.34593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048745964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e3181f7266b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048934624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e3181f7266b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048934624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e3181f7266b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048934624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/s10165-011-0508-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049497864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2007.11.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049608209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000071516.54864.c1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050081581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000071516.54864.c1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050081581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpa.0b013e31819d73ca", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050512252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpa.0b013e31819d73ca", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050512252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpa.0b013e31819d73ca", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050512252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-003-1175-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051457593", 
              "https://doi.org/10.1007/s00535-003-1175-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1546-0096-9-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052925078", 
              "https://doi.org/10.1186/1546-0096-9-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2012/198314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053678968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10067-017-3542-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053778078", 
              "https://doi.org/10.1007/s10067-017-3542-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10067-017-3542-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053778078", 
              "https://doi.org/10.1007/s10067-017-3542-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/thy.2013.0211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059321724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/kev438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060012723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/kev438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060012723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v20.i41.15177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071371752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078184856", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078326943", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3238/arztebl.2015.0128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079054679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079402341", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-02", 
        "datePublishedReg": "2018-02-01", 
        "description": "IgG4-related disease (IgG4-RD) encompasses a spectrum of complex fibro-inflammatory disorders which are often under diagnosed due to unfamiliarity by clinicians. A challenging multitude of clinical manifestations makes the diagnosis cumbersome. The primary clinical feature in IgG4-RD entails a tumor-like presentation coupled with tissue-destructive lesions. Histopathological findings include lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis. These findings, in combination with elevated serum immunoglobulin G4 levels, are diagnostic in the setting of single- or multi-organ involvement. A closer understanding of the role of T cells and B cells in the increased production of IgG4 has led to a notion that IgG4 can act as a pathogen, anti-inflammatory agent, or rheumatoid factor. Glucocorticoids are the primary treatment modality; however, relapse is common with prolonged therapy. Alternatively, immunomodulatory agents are being increasingly used as therapy. The aim of this article is to raise awareness of IgG4-RD and review the diagnostic algorithm, as IgG4-RD often mimics a wide array of clinical conditions. In addition, we summarize the pathogenesis and current treatment guidelines of IgG4-RD for clinicians. Awareness and accurate diagnosis are crucial in preventing progression to chronic diseases, thereby diminishing disease-related morbidity and mortality.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00296-017-3765-7", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1093123", 
            "issn": [
              "0172-8172", 
              "1437-160X"
            ], 
            "name": "Rheumatology International", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "38"
          }
        ], 
        "name": "IgG4-related disease: a complex under-diagnosed clinical entity", 
        "pagination": "169-177", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "86e9cead5f082c64005288085f6dd37103a1c3143a3ebbe5ab76d32a2800f8c6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28681251"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8206885"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00296-017-3765-7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1090358444"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00296-017-3765-7", 
          "https://app.dimensions.ai/details/publication/pub.1090358444"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:35", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70027_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00296-017-3765-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00296-017-3765-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00296-017-3765-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00296-017-3765-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00296-017-3765-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    392 TRIPLES      21 PREDICATES      120 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00296-017-3765-7 schema:about N2b811667c294485e83f73adf68a91105
    2 N2e11a7dd351f4deab3fcd440d888bc93
    3 N3880fd6e1dfa49938474f9b3db4e5e6e
    4 N3af60a38e036437b91d63a091318848a
    5 N7233a447f5724235926c3d0a553dc6aa
    6 N735a12dabe0c490caa7f13f1d6c62f70
    7 N7ef2c7c925644145b08e2150a5f05235
    8 N80dd57d095d74ffea0e4db0f1f3d0e42
    9 N940d98f364ca4e76bb68d5b76905175b
    10 Na78b023908324f4fb33cf2d2e36b1e1f
    11 Naf102ea3e1654c56b3b55f1c7ffe329b
    12 Nbb578869424641baa2c13c8a41fe8f7b
    13 Nbd684a7137144e168653b3935f5630c9
    14 Nebe4f90acffd40a3b553c423c86758a8
    15 Nfae5f4d5dcf142418e82b5f81ed9cba9
    16 Nfca8b4737e584cdc9070ebbaf969d4ca
    17 anzsrc-for:11
    18 anzsrc-for:1103
    19 schema:author N605f2ecf825842669c34f563c7397868
    20 schema:citation sg:pub.10.1007/s00251-006-0178-2
    21 sg:pub.10.1007/s00535-003-1175-y
    22 sg:pub.10.1007/s00535-010-0323-4
    23 sg:pub.10.1007/s00535-011-0386-x
    24 sg:pub.10.1007/s10067-017-3542-8
    25 sg:pub.10.1007/s10165-011-0571-z
    26 sg:pub.10.1007/s11739-016-1599-z
    27 sg:pub.10.1007/s12016-014-8430-2
    28 sg:pub.10.1038/ajg.2010.141
    29 sg:pub.10.1038/ajg.2012.465
    30 sg:pub.10.1038/ajg.2014.223
    31 sg:pub.10.1038/ki.2010.271
    32 sg:pub.10.1038/modpathol.2011.177
    33 sg:pub.10.1038/modpathol.2012.72
    34 sg:pub.10.1111/j.1572-0241.2007.01750.x
    35 sg:pub.10.1186/1546-0096-9-1
    36 https://app.dimensions.ai/details/publication/pub.1078184856
    37 https://app.dimensions.ai/details/publication/pub.1078326943
    38 https://app.dimensions.ai/details/publication/pub.1079402341
    39 https://doi.org/10.1002/art.34593
    40 https://doi.org/10.1002/art.39132
    41 https://doi.org/10.1002/art.39205
    42 https://doi.org/10.1007/s10165-011-0508-6
    43 https://doi.org/10.1016/j.autrev.2014.08.013
    44 https://doi.org/10.1016/j.cgh.2009.07.041
    45 https://doi.org/10.1016/j.dld.2011.03.006
    46 https://doi.org/10.1016/j.semarthrit.2013.11.008
    47 https://doi.org/10.1053/gast.2002.33022
    48 https://doi.org/10.1053/j.gastro.2007.11.023
    49 https://doi.org/10.1056/nejm200103083441005
    50 https://doi.org/10.1056/nejmcpc1209330
    51 https://doi.org/10.1056/nejmoa0903068
    52 https://doi.org/10.1056/nejmra1104650
    53 https://doi.org/10.1089/thy.2013.0211
    54 https://doi.org/10.1093/rheumatology/keq113
    55 https://doi.org/10.1093/rheumatology/kev438
    56 https://doi.org/10.1097/01.mpa.0000226881.48204.fd
    57 https://doi.org/10.1097/01.pas.0000213331.09864.2c
    58 https://doi.org/10.1097/01.sla.0000071516.54864.c1
    59 https://doi.org/10.1097/bor.0b013e3283412f7c
    60 https://doi.org/10.1097/bor.0b013e3283412fd4
    61 https://doi.org/10.1097/bor.0b013e328341a240
    62 https://doi.org/10.1097/md.0000000000001366
    63 https://doi.org/10.1097/mpa.0b013e31819d73ca
    64 https://doi.org/10.1097/mpa.0b013e31826bef91
    65 https://doi.org/10.1097/pas.0b013e3181342f0d
    66 https://doi.org/10.1097/pas.0b013e3181f7266b
    67 https://doi.org/10.1111/bjd.13296
    68 https://doi.org/10.1111/his.12122
    69 https://doi.org/10.1111/j.1365-2222.2009.03207.x
    70 https://doi.org/10.1111/j.1582-4934.2005.tb00506.x
    71 https://doi.org/10.1126/science.1144603
    72 https://doi.org/10.1128/cdli.12.5.632-639.2005
    73 https://doi.org/10.1136/annrheumdis-2014-205233
    74 https://doi.org/10.1136/gut.2004.047142
    75 https://doi.org/10.1136/gut.2004.049064
    76 https://doi.org/10.1136/gut.2006.095059
    77 https://doi.org/10.1136/jcp.2010.085613
    78 https://doi.org/10.1146/annurev-pathol-012513-104708
    79 https://doi.org/10.1155/2012/139409
    80 https://doi.org/10.1155/2012/198314
    81 https://doi.org/10.1155/2012/259408
    82 https://doi.org/10.1155/2012/358371
    83 https://doi.org/10.1155/2012/572539
    84 https://doi.org/10.1155/2012/602809
    85 https://doi.org/10.1155/2015/591360
    86 https://doi.org/10.1177/2050640614532457
    87 https://doi.org/10.1371/journal.pone.0001637
    88 https://doi.org/10.1373/clinchem.2007.085951
    89 https://doi.org/10.3109/s10165-011-0508-6
    90 https://doi.org/10.3109/s10165-011-0571-z
    91 https://doi.org/10.3238/arztebl.2015.0128
    92 https://doi.org/10.3348/kjr.2015.16.5.1056
    93 https://doi.org/10.3748/wjg.v20.i41.15177
    94 https://doi.org/10.3960/jslrt.51.13
    95 schema:datePublished 2018-02
    96 schema:datePublishedReg 2018-02-01
    97 schema:description IgG4-related disease (IgG4-RD) encompasses a spectrum of complex fibro-inflammatory disorders which are often under diagnosed due to unfamiliarity by clinicians. A challenging multitude of clinical manifestations makes the diagnosis cumbersome. The primary clinical feature in IgG4-RD entails a tumor-like presentation coupled with tissue-destructive lesions. Histopathological findings include lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis. These findings, in combination with elevated serum immunoglobulin G4 levels, are diagnostic in the setting of single- or multi-organ involvement. A closer understanding of the role of T cells and B cells in the increased production of IgG4 has led to a notion that IgG4 can act as a pathogen, anti-inflammatory agent, or rheumatoid factor. Glucocorticoids are the primary treatment modality; however, relapse is common with prolonged therapy. Alternatively, immunomodulatory agents are being increasingly used as therapy. The aim of this article is to raise awareness of IgG4-RD and review the diagnostic algorithm, as IgG4-RD often mimics a wide array of clinical conditions. In addition, we summarize the pathogenesis and current treatment guidelines of IgG4-RD for clinicians. Awareness and accurate diagnosis are crucial in preventing progression to chronic diseases, thereby diminishing disease-related morbidity and mortality.
    98 schema:genre research_article
    99 schema:inLanguage en
    100 schema:isAccessibleForFree false
    101 schema:isPartOf N284023f468774c51a6041dbb1de400e5
    102 Ndc9eb90529b2487b88a2383249a1036d
    103 sg:journal.1093123
    104 schema:name IgG4-related disease: a complex under-diagnosed clinical entity
    105 schema:pagination 169-177
    106 schema:productId N0ebb7a11f9b346efa7ce21bdf8201acf
    107 N5160c9280999422ea7ad6aecff21c81b
    108 N534db767fd2343f5bdba083527ff4ce6
    109 Na5d2ece0920c44a59abb49a983fd3948
    110 Nc8351551b16b4fc28b04cd50d81a8685
    111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090358444
    112 https://doi.org/10.1007/s00296-017-3765-7
    113 schema:sdDatePublished 2019-04-11T12:35
    114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    115 schema:sdPublisher N78e1c82feee04fe798f9981ef6c368f9
    116 schema:url https://link.springer.com/10.1007%2Fs00296-017-3765-7
    117 sgo:license sg:explorer/license/
    118 sgo:sdDataset articles
    119 rdf:type schema:ScholarlyArticle
    120 N0ebb7a11f9b346efa7ce21bdf8201acf schema:name doi
    121 schema:value 10.1007/s00296-017-3765-7
    122 rdf:type schema:PropertyValue
    123 N284023f468774c51a6041dbb1de400e5 schema:issueNumber 2
    124 rdf:type schema:PublicationIssue
    125 N2b811667c294485e83f73adf68a91105 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Inflammation
    127 rdf:type schema:DefinedTerm
    128 N2e11a7dd351f4deab3fcd440d888bc93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Clinical Decision-Making
    130 rdf:type schema:DefinedTerm
    131 N3880fd6e1dfa49938474f9b3db4e5e6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Humans
    133 rdf:type schema:DefinedTerm
    134 N3af60a38e036437b91d63a091318848a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Fibrosis
    136 rdf:type schema:DefinedTerm
    137 N5160c9280999422ea7ad6aecff21c81b schema:name readcube_id
    138 schema:value 86e9cead5f082c64005288085f6dd37103a1c3143a3ebbe5ab76d32a2800f8c6
    139 rdf:type schema:PropertyValue
    140 N534db767fd2343f5bdba083527ff4ce6 schema:name nlm_unique_id
    141 schema:value 8206885
    142 rdf:type schema:PropertyValue
    143 N605f2ecf825842669c34f563c7397868 rdf:first sg:person.01134620611.05
    144 rdf:rest Ndef46783769e4849acb2c0fa2272e26c
    145 N7233a447f5724235926c3d0a553dc6aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Immunoglobulin G
    147 rdf:type schema:DefinedTerm
    148 N735a12dabe0c490caa7f13f1d6c62f70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Algorithms
    150 rdf:type schema:DefinedTerm
    151 N78e1c82feee04fe798f9981ef6c368f9 schema:name Springer Nature - SN SciGraph project
    152 rdf:type schema:Organization
    153 N7ef2c7c925644145b08e2150a5f05235 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Diagnosis, Differential
    155 rdf:type schema:DefinedTerm
    156 N80dd57d095d74ffea0e4db0f1f3d0e42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Risk Factors
    158 rdf:type schema:DefinedTerm
    159 N940d98f364ca4e76bb68d5b76905175b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Treatment Outcome
    161 rdf:type schema:DefinedTerm
    162 Na5d2ece0920c44a59abb49a983fd3948 schema:name pubmed_id
    163 schema:value 28681251
    164 rdf:type schema:PropertyValue
    165 Na78b023908324f4fb33cf2d2e36b1e1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Predictive Value of Tests
    167 rdf:type schema:DefinedTerm
    168 Naf102ea3e1654c56b3b55f1c7ffe329b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Autoimmunity
    170 rdf:type schema:DefinedTerm
    171 Nbb578869424641baa2c13c8a41fe8f7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Animals
    173 rdf:type schema:DefinedTerm
    174 Nbd684a7137144e168653b3935f5630c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Autoimmune Diseases
    176 rdf:type schema:DefinedTerm
    177 Nc8351551b16b4fc28b04cd50d81a8685 schema:name dimensions_id
    178 schema:value pub.1090358444
    179 rdf:type schema:PropertyValue
    180 Ndaa1ea498f02468da42bbc469f3aa866 rdf:first sg:person.01146105417.56
    181 rdf:rest rdf:nil
    182 Ndc9eb90529b2487b88a2383249a1036d schema:volumeNumber 38
    183 rdf:type schema:PublicationVolume
    184 Ndef46783769e4849acb2c0fa2272e26c rdf:first sg:person.016170370352.86
    185 rdf:rest Ndaa1ea498f02468da42bbc469f3aa866
    186 Nebe4f90acffd40a3b553c423c86758a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Glucocorticoids
    188 rdf:type schema:DefinedTerm
    189 Nfae5f4d5dcf142418e82b5f81ed9cba9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Biomarkers
    191 rdf:type schema:DefinedTerm
    192 Nfca8b4737e584cdc9070ebbaf969d4ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Immunosuppressive Agents
    194 rdf:type schema:DefinedTerm
    195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    196 schema:name Medical and Health Sciences
    197 rdf:type schema:DefinedTerm
    198 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    199 schema:name Clinical Sciences
    200 rdf:type schema:DefinedTerm
    201 sg:journal.1093123 schema:issn 0172-8172
    202 1437-160X
    203 schema:name Rheumatology International
    204 rdf:type schema:Periodical
    205 sg:person.01134620611.05 schema:affiliation https://www.grid.ac/institutes/grid.239276.b
    206 schema:familyName Yadlapati
    207 schema:givenName Sujani
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134620611.05
    209 rdf:type schema:Person
    210 sg:person.01146105417.56 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
    211 schema:familyName Efthimiou
    212 schema:givenName Petros
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146105417.56
    214 rdf:type schema:Person
    215 sg:person.016170370352.86 schema:affiliation https://www.grid.ac/institutes/grid.240873.a
    216 schema:familyName Verheyen
    217 schema:givenName Elijah
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016170370352.86
    219 rdf:type schema:Person
    220 sg:pub.10.1007/s00251-006-0178-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035213611
    221 https://doi.org/10.1007/s00251-006-0178-2
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1007/s00535-003-1175-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1051457593
    224 https://doi.org/10.1007/s00535-003-1175-y
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1007/s00535-010-0323-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020994716
    227 https://doi.org/10.1007/s00535-010-0323-4
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1007/s00535-011-0386-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019125874
    230 https://doi.org/10.1007/s00535-011-0386-x
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1007/s10067-017-3542-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053778078
    233 https://doi.org/10.1007/s10067-017-3542-8
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1007/s10165-011-0571-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1039029422
    236 https://doi.org/10.1007/s10165-011-0571-z
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1007/s11739-016-1599-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1033520422
    239 https://doi.org/10.1007/s11739-016-1599-z
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1007/s12016-014-8430-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006537330
    242 https://doi.org/10.1007/s12016-014-8430-2
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/ajg.2010.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030977695
    245 https://doi.org/10.1038/ajg.2010.141
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/ajg.2012.465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006914660
    248 https://doi.org/10.1038/ajg.2012.465
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/ajg.2014.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028432816
    251 https://doi.org/10.1038/ajg.2014.223
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/ki.2010.271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034572106
    254 https://doi.org/10.1038/ki.2010.271
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/modpathol.2011.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010123852
    257 https://doi.org/10.1038/modpathol.2011.177
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/modpathol.2012.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022783314
    260 https://doi.org/10.1038/modpathol.2012.72
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1111/j.1572-0241.2007.01750.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017337415
    263 https://doi.org/10.1111/j.1572-0241.2007.01750.x
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1186/1546-0096-9-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052925078
    266 https://doi.org/10.1186/1546-0096-9-1
    267 rdf:type schema:CreativeWork
    268 https://app.dimensions.ai/details/publication/pub.1078184856 schema:CreativeWork
    269 https://app.dimensions.ai/details/publication/pub.1078326943 schema:CreativeWork
    270 https://app.dimensions.ai/details/publication/pub.1079402341 schema:CreativeWork
    271 https://doi.org/10.1002/art.34593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048745964
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/art.39132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022851625
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1002/art.39205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026660595
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1007/s10165-011-0508-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012374983
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.autrev.2014.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035643873
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.cgh.2009.07.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009666736
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.dld.2011.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046414691
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.semarthrit.2013.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001981399
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1053/gast.2002.33022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036172285
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1053/j.gastro.2007.11.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049608209
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1056/nejm200103083441005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015560931
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1056/nejmcpc1209330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040545877
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1056/nejmoa0903068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038004174
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1056/nejmra1104650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037514297
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1089/thy.2013.0211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059321724
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1093/rheumatology/keq113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019778979
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1093/rheumatology/kev438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060012723
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1097/01.mpa.0000226881.48204.fd schema:sameAs https://app.dimensions.ai/details/publication/pub.1040203359
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1097/01.pas.0000213331.09864.2c schema:sameAs https://app.dimensions.ai/details/publication/pub.1018462014
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1097/01.sla.0000071516.54864.c1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050081581
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1097/bor.0b013e3283412f7c schema:sameAs https://app.dimensions.ai/details/publication/pub.1013143090
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1097/bor.0b013e3283412fd4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039834024
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1097/bor.0b013e328341a240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031335557
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1097/md.0000000000001366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000820271
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1097/mpa.0b013e31819d73ca schema:sameAs https://app.dimensions.ai/details/publication/pub.1050512252
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1097/mpa.0b013e31826bef91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026769188
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1097/pas.0b013e3181342f0d schema:sameAs https://app.dimensions.ai/details/publication/pub.1022618751
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1097/pas.0b013e3181f7266b schema:sameAs https://app.dimensions.ai/details/publication/pub.1048934624
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1111/bjd.13296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007324265
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1111/his.12122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042330264
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1111/j.1365-2222.2009.03207.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000911660
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1111/j.1582-4934.2005.tb00506.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017714569
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1126/science.1144603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022714329
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1128/cdli.12.5.632-639.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006214557
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1136/annrheumdis-2014-205233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034747568
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1136/gut.2004.047142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007686599
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1136/gut.2004.049064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002436536
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1136/gut.2006.095059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042682301
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1136/jcp.2010.085613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022600702
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1146/annurev-pathol-012513-104708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028429359
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1155/2012/139409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014512805
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1155/2012/198314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053678968
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1155/2012/259408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003894712
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1155/2012/358371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040240254
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1155/2012/572539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021908577
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1155/2012/602809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024171151
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1155/2015/591360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013289764
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1177/2050640614532457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019179426
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1371/journal.pone.0001637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041768901
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1373/clinchem.2007.085951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043059833
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.3109/s10165-011-0508-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049497864
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.3109/s10165-011-0571-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1015464107
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.3238/arztebl.2015.0128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079054679
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.3348/kjr.2015.16.5.1056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042593716
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.3748/wjg.v20.i41.15177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071371752
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.3960/jslrt.51.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010143029
    382 rdf:type schema:CreativeWork
    383 https://www.grid.ac/institutes/grid.239276.b schema:alternateName Albert Einstein Medical Center
    384 schema:name Department of Internal Medicine, Albert Einstein Medical Center, Philadelphia, PA, USA
    385 rdf:type schema:Organization
    386 https://www.grid.ac/institutes/grid.240873.a schema:alternateName St. Luke's-Roosevelt Hospital Center
    387 schema:name Department of Internal Medicine, St. Luke’s-Roosevelt Hospital Center, New York, NY, USA
    388 rdf:type schema:Organization
    389 https://www.grid.ac/institutes/grid.5386.8 schema:alternateName Cornell University
    390 schema:name Division of Rheumatology, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA
    391 Weill Cornell Medical College, New York, NY, USA
    392 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...