Hypothermia induced by adenosine 5′-monophosphate attenuates early stage injury in an acute gouty arthritis rat model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-02-14

AUTHORS

Zhimin Miao, Weiting Guo, Shulai Lu, Wenshan Lv, Changgui Li, Yangang Wang, Shihua Zhao, Shengli Yan, Zhenyin Tao, Yunlong Wang

ABSTRACT

To investigate whether the hypothermia induced by Adenosine 5′-Monophosphate (5′-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5′-AMP and then observe whether hypothermia induced by 5′-AMP could be effectively inhibit the inflammation on acute gouty arthritis in rats. AMP-induced hypothermia has protective effects on our acute gouty arthritis, which was demonstrated by the following criteria: (1) a significant reduction in the ankle swelling (p < 0.001); (2) a significant decrease in the occurrence of leukocyte infiltration and mild hemorrhage; (3) a significant reduction in the presence of serum Interleukin-1β (IL-1β, p < 0.001) and metalloproteinase-9 (MMP-9, p < 0.001); and (4) a significant inhibition in the Nuclear Factor -κappaB (NF-κB) activity (p < 0.001). AMP-induced hypothermia could inhibit acute inflammation reaction and protect the synovial tissue against acute injury in a rat acute gouty arthritis model. More... »

PAGES

2085-2092

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00296-013-2676-5

DOI

http://dx.doi.org/10.1007/s00296-013-2676-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036661757

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23408150


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