Behçet’s disease: immunological relevance with arthritis of ankylosing spondylitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-03

AUTHORS

Esin Aktas Cetin, Fulya Cosan, Umut Can Kucuksezer, Sema Bilgic, Yonca Cagatay, Ahmet Gul, Gunnur Deniz

ABSTRACT

Behçet's disease (BD) is a multi-system inflammatory disorder, in which cytokine balance is polarized to Th1. In this study, the cell surface molecule expression, Th1/Th2, inflammatory cytokine levels in blood, and synovial fluid of CD3(+) T lymphocytes in BD were investigated. The study group consisted of 10 BD, 10 ankylosing spondylitis (AS) patients with peripheral arthritis, and 10 healthy subjects. Expression of cell surface molecules, intracellular IL-2, IL-5, IL-8, IL-10, IL-12, IFN-γ, and TNF-α levels in CD3(+) T lymphocytes were determined by flow cytometry in synovial and peripheral blood mononuclear cells (PBMCs). Synovial and plasma cytokine levels were measured by ELISA and CBA. In PBMCs, CD4, CD25, HLA-DR expression and intracellular IL-12, and TNF-α levels of CD3(+) T lymphocytes were statistically increased in BD patients compared to healthy subjects. Compare to AS patients, CD25 and HLA-DR surface expression and intracellular IFN-γ and TNF-α levels in T cells were significantly elevated in BD patients. In BD patients, there was an increase in IL-8 secretion; however, in AS patients, both Th1- and Th2-type cytokines were increased compare to healthy subjects. Intracellular cytokine expression did not show any difference in BD patients; however, IL-12 content of synovial fluid was significantly increased compared to AS patients. Our findings revealed that Th1 polarization occurred in both peripheral blood and synovial fluid of BD patients with arthritis. It is found no difference between synovial fluid analysis of BD and AS patients, showing the similarities in the pathogenesis of both diseases. More... »

PAGES

733-741

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00296-012-2446-9

DOI

http://dx.doi.org/10.1007/s00296-012-2446-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048246301

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22576660


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Behcet Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA-DR Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-12", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-2 Receptor alpha Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spondylitis, Ankylosing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synovial Fluid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Th1 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Th2 Cells", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istanbul University", 
          "id": "https://www.grid.ac/institutes/grid.9601.e", 
          "name": [
            "Department of Immunology, Institute of Experimental Medicine (DETAE), Istanbul University, Vakif Gureba Caddesi, Sehremini, 34393, Istanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aktas Cetin", 
        "givenName": "Esin", 
        "id": "sg:person.0704052040.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704052040.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istanbul University", 
          "id": "https://www.grid.ac/institutes/grid.9601.e", 
          "name": [
            "Department of Immunology, Institute of Experimental Medicine (DETAE), Istanbul University, Vakif Gureba Caddesi, Sehremini, 34393, Istanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cosan", 
        "givenName": "Fulya", 
        "id": "sg:person.01170453603.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170453603.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istanbul University", 
          "id": "https://www.grid.ac/institutes/grid.9601.e", 
          "name": [
            "Department of Immunology, Institute of Experimental Medicine (DETAE), Istanbul University, Vakif Gureba Caddesi, Sehremini, 34393, Istanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kucuksezer", 
        "givenName": "Umut Can", 
        "id": "sg:person.01070370461.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070370461.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istanbul University", 
          "id": "https://www.grid.ac/institutes/grid.9601.e", 
          "name": [
            "Department of Immunology, Institute of Experimental Medicine (DETAE), Istanbul University, Vakif Gureba Caddesi, Sehremini, 34393, Istanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bilgic", 
        "givenName": "Sema", 
        "id": "sg:person.0702071646.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702071646.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istanbul University", 
          "id": "https://www.grid.ac/institutes/grid.9601.e", 
          "name": [
            "Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cagatay", 
        "givenName": "Yonca", 
        "id": "sg:person.0663645744.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663645744.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istanbul University", 
          "id": "https://www.grid.ac/institutes/grid.9601.e", 
          "name": [
            "Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gul", 
        "givenName": "Ahmet", 
        "id": "sg:person.0603062573.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603062573.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istanbul University", 
          "id": "https://www.grid.ac/institutes/grid.9601.e", 
          "name": [
            "Department of Immunology, Institute of Experimental Medicine (DETAE), Istanbul University, Vakif Gureba Caddesi, Sehremini, 34393, Istanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deniz", 
        "givenName": "Gunnur", 
        "id": "sg:person.0622716501.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622716501.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1365-2133.1995.tb16946.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000339411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.1995.tb16946.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000339411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(93)90244-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000584596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(93)90244-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000584596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1346-8138.2003.tb00442.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002154183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-003-0851-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002655893", 
          "https://doi.org/10.1007/s10067-003-0851-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005574545", 
          "https://doi.org/10.1038/ng.624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004030000128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009085358", 
          "https://doi.org/10.1007/s004030000128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/03009740600905380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009253458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar2608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010200597", 
          "https://doi.org/10.1186/ar2608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1346-8138.1998.tb02372.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010758164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-005-0040-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010913821", 
          "https://doi.org/10.1007/s00296-005-0040-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-005-0040-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010913821", 
          "https://doi.org/10.1007/s00296-005-0040-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-005-0040-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010913821", 
          "https://doi.org/10.1007/s00296-005-0040-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-005-0040-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010913821", 
          "https://doi.org/10.1007/s00296-005-0040-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2011/681956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014113709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08916939209148460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014664937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0603252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016741207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-4632.2009.03905.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017700575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.intimp.2004.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021049298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2010.11.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021717863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/03009740701747137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025262870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.174.4.915", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028873499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2249.1997.00299.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031139786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032813793", 
          "https://doi.org/10.1038/ng.625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0923-1811(96)00588-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035403248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.17.1.331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041081468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/09629350220131935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043047450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2230.2004.01684.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043453589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-009-1205-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043757116", 
          "https://doi.org/10.1007/s10067-009-1205-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-009-1205-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043757116", 
          "https://doi.org/10.1007/s10067-009-1205-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-009-1205-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043757116", 
          "https://doi.org/10.1007/s10067-009-1205-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3129/i07-179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045704997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1346-8138.1998.tb02446.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048180665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051485127", 
          "https://doi.org/10.1038/ni1254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051485127", 
          "https://doi.org/10.1038/ni1254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajo.2006.04.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051729669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2249.1997.d01-947.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056734185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/31.5.299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060010027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074763669", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074966504", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077503805", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078224292", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082986158", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083221903", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083258057", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-03", 
    "datePublishedReg": "2013-03-01", 
    "description": "Beh\u00e7et's disease (BD) is a multi-system inflammatory disorder, in which cytokine balance is polarized to Th1. In this study, the cell surface molecule expression, Th1/Th2, inflammatory cytokine levels in blood, and synovial fluid of CD3(+) T lymphocytes in BD were investigated. The study group consisted of 10 BD, 10 ankylosing spondylitis (AS) patients with peripheral arthritis, and 10 healthy subjects. Expression of cell surface molecules, intracellular IL-2, IL-5, IL-8, IL-10, IL-12, IFN-\u03b3, and TNF-\u03b1 levels in CD3(+) T lymphocytes were determined by flow cytometry in synovial and peripheral blood mononuclear cells (PBMCs). Synovial and plasma cytokine levels were measured by ELISA and CBA. In PBMCs, CD4, CD25, HLA-DR expression and intracellular IL-12, and TNF-\u03b1 levels of CD3(+) T lymphocytes were statistically increased in BD patients compared to healthy subjects. Compare to AS patients, CD25 and HLA-DR surface expression and intracellular IFN-\u03b3 and TNF-\u03b1 levels in T cells were significantly elevated in BD patients. In BD patients, there was an increase in IL-8 secretion; however, in AS patients, both Th1- and Th2-type cytokines were increased compare to healthy subjects. Intracellular cytokine expression did not show any difference in BD patients; however, IL-12 content of synovial fluid was significantly increased compared to AS patients. Our findings revealed that Th1 polarization occurred in both peripheral blood and synovial fluid of BD patients with arthritis. It is found no difference between synovial fluid analysis of BD and AS patients, showing the similarities in the pathogenesis of both diseases.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00296-012-2446-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1093123", 
        "issn": [
          "0172-8172", 
          "1437-160X"
        ], 
        "name": "Rheumatology International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "33"
      }
    ], 
    "name": "Beh\u00e7et\u2019s disease: immunological relevance with arthritis of ankylosing spondylitis", 
    "pagination": "733-741", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e5d6d914fe63beab562e660d5d4914e2860f517deadc3ea3448abca6c43519a8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22576660"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8206885"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00296-012-2446-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048246301"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00296-012-2446-9", 
      "https://app.dimensions.ai/details/publication/pub.1048246301"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000516.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00296-012-2446-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00296-012-2446-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00296-012-2446-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00296-012-2446-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00296-012-2446-9'


 

This table displays all metadata directly associated to this object as RDF triples.

275 TRIPLES      21 PREDICATES      79 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00296-012-2446-9 schema:about N1c543b466ebd47988a017080bb7a594b
2 N229392718203440d84daf6c5abe20030
3 N2d59b71e9293475abba23d8c208a40e8
4 N359df2d27e634f33972d49424abc792f
5 N428394579549492cb4ce2113e2bf77c7
6 N4449851f3cbd45abb773cd3ecdf36bb0
7 N4825f01f5e6246a193e029260b7c3ce0
8 N4a0f5f88a241488d802ac8bf9ae01fd0
9 N5b81a0c2a36442ae936e1e606c726fdf
10 Nbc0deadab81e4dee8517fbe733e9facf
11 Nc36416ebd8784e3d9270d2e1ee22bf6f
12 Nd89b016ba87144969895b7f93ecb8afc
13 anzsrc-for:11
14 anzsrc-for:1107
15 schema:author N5562b5a22e7e4b70a00e5810e38ca731
16 schema:citation sg:pub.10.1007/s00296-005-0040-0
17 sg:pub.10.1007/s004030000128
18 sg:pub.10.1007/s10067-003-0851-x
19 sg:pub.10.1007/s10067-009-1205-0
20 sg:pub.10.1038/ng.624
21 sg:pub.10.1038/ng.625
22 sg:pub.10.1038/ni1254
23 sg:pub.10.1186/ar2608
24 https://app.dimensions.ai/details/publication/pub.1074763669
25 https://app.dimensions.ai/details/publication/pub.1074966504
26 https://app.dimensions.ai/details/publication/pub.1077503805
27 https://app.dimensions.ai/details/publication/pub.1078224292
28 https://app.dimensions.ai/details/publication/pub.1082986158
29 https://app.dimensions.ai/details/publication/pub.1083221903
30 https://app.dimensions.ai/details/publication/pub.1083258057
31 https://doi.org/10.1016/0167-5699(93)90244-f
32 https://doi.org/10.1016/j.ajo.2006.04.016
33 https://doi.org/10.1016/j.intimp.2004.01.007
34 https://doi.org/10.1016/j.jaci.2010.11.050
35 https://doi.org/10.1016/s0923-1811(96)00588-9
36 https://doi.org/10.1046/j.1365-2249.1997.00299.x
37 https://doi.org/10.1046/j.1365-2249.1997.d01-947.x
38 https://doi.org/10.1080/03009740600905380
39 https://doi.org/10.1080/03009740701747137
40 https://doi.org/10.1080/09629350220131935
41 https://doi.org/10.1084/jem.174.4.915
42 https://doi.org/10.1093/rheumatology/31.5.299
43 https://doi.org/10.1111/j.1346-8138.1998.tb02372.x
44 https://doi.org/10.1111/j.1346-8138.1998.tb02446.x
45 https://doi.org/10.1111/j.1346-8138.2003.tb00442.x
46 https://doi.org/10.1111/j.1365-2133.1995.tb16946.x
47 https://doi.org/10.1111/j.1365-2230.2004.01684.x
48 https://doi.org/10.1111/j.1365-4632.2009.03905.x
49 https://doi.org/10.1146/annurev.immunol.17.1.331
50 https://doi.org/10.1155/2011/681956
51 https://doi.org/10.1189/jlb.0603252
52 https://doi.org/10.3109/08916939209148460
53 https://doi.org/10.3129/i07-179
54 schema:datePublished 2013-03
55 schema:datePublishedReg 2013-03-01
56 schema:description Behçet's disease (BD) is a multi-system inflammatory disorder, in which cytokine balance is polarized to Th1. In this study, the cell surface molecule expression, Th1/Th2, inflammatory cytokine levels in blood, and synovial fluid of CD3(+) T lymphocytes in BD were investigated. The study group consisted of 10 BD, 10 ankylosing spondylitis (AS) patients with peripheral arthritis, and 10 healthy subjects. Expression of cell surface molecules, intracellular IL-2, IL-5, IL-8, IL-10, IL-12, IFN-γ, and TNF-α levels in CD3(+) T lymphocytes were determined by flow cytometry in synovial and peripheral blood mononuclear cells (PBMCs). Synovial and plasma cytokine levels were measured by ELISA and CBA. In PBMCs, CD4, CD25, HLA-DR expression and intracellular IL-12, and TNF-α levels of CD3(+) T lymphocytes were statistically increased in BD patients compared to healthy subjects. Compare to AS patients, CD25 and HLA-DR surface expression and intracellular IFN-γ and TNF-α levels in T cells were significantly elevated in BD patients. In BD patients, there was an increase in IL-8 secretion; however, in AS patients, both Th1- and Th2-type cytokines were increased compare to healthy subjects. Intracellular cytokine expression did not show any difference in BD patients; however, IL-12 content of synovial fluid was significantly increased compared to AS patients. Our findings revealed that Th1 polarization occurred in both peripheral blood and synovial fluid of BD patients with arthritis. It is found no difference between synovial fluid analysis of BD and AS patients, showing the similarities in the pathogenesis of both diseases.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N344f7c48128e4b009165f94f6125fb0d
61 Nb46694f6182843be8272cee6daee3a2e
62 sg:journal.1093123
63 schema:name Behçet’s disease: immunological relevance with arthritis of ankylosing spondylitis
64 schema:pagination 733-741
65 schema:productId N2925488d267a460086232bfb9ca7f6cd
66 N405f8a92798042d0a205c8229bd4305c
67 Nbf6901aec94546cf883432ef9a647055
68 Nd567bab1661241ccb74201e5f50b5d17
69 Nfd2378bd2142423787bdd4c91ae00051
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048246301
71 https://doi.org/10.1007/s00296-012-2446-9
72 schema:sdDatePublished 2019-04-10T16:43
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Ncd83405a8c1f4683933910a6e21e9c8b
75 schema:url http://link.springer.com/10.1007%2Fs00296-012-2446-9
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N087a0b9ff547422da2f466d0bfe7ee99 rdf:first sg:person.0603062573.29
80 rdf:rest N604cf523bd0f4ec9a17b848e54cd79c2
81 N1c543b466ebd47988a017080bb7a594b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Th2 Cells
83 rdf:type schema:DefinedTerm
84 N229392718203440d84daf6c5abe20030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Interleukin-12
86 rdf:type schema:DefinedTerm
87 N2925488d267a460086232bfb9ca7f6cd schema:name doi
88 schema:value 10.1007/s00296-012-2446-9
89 rdf:type schema:PropertyValue
90 N2d59b71e9293475abba23d8c208a40e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Interleukin-2 Receptor alpha Subunit
92 rdf:type schema:DefinedTerm
93 N344f7c48128e4b009165f94f6125fb0d schema:volumeNumber 33
94 rdf:type schema:PublicationVolume
95 N359df2d27e634f33972d49424abc792f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Th1 Cells
97 rdf:type schema:DefinedTerm
98 N405f8a92798042d0a205c8229bd4305c schema:name nlm_unique_id
99 schema:value 8206885
100 rdf:type schema:PropertyValue
101 N428394579549492cb4ce2113e2bf77c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Humans
103 rdf:type schema:DefinedTerm
104 N4449851f3cbd45abb773cd3ecdf36bb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name HLA-DR Antigens
106 rdf:type schema:DefinedTerm
107 N4825f01f5e6246a193e029260b7c3ce0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Flow Cytometry
109 rdf:type schema:DefinedTerm
110 N4a0f5f88a241488d802ac8bf9ae01fd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Interferon-gamma
112 rdf:type schema:DefinedTerm
113 N5562b5a22e7e4b70a00e5810e38ca731 rdf:first sg:person.0704052040.12
114 rdf:rest Nf367ea2b5cba45b1a7d5f8aa906dfcd9
115 N5b81a0c2a36442ae936e1e606c726fdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Synovial Fluid
117 rdf:type schema:DefinedTerm
118 N604cf523bd0f4ec9a17b848e54cd79c2 rdf:first sg:person.0622716501.27
119 rdf:rest rdf:nil
120 N8abbb52c80b748edb3f9cd6b9b50186d rdf:first sg:person.0663645744.78
121 rdf:rest N087a0b9ff547422da2f466d0bfe7ee99
122 Nb46694f6182843be8272cee6daee3a2e schema:issueNumber 3
123 rdf:type schema:PublicationIssue
124 Nbc0deadab81e4dee8517fbe733e9facf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Behcet Syndrome
126 rdf:type schema:DefinedTerm
127 Nbf6901aec94546cf883432ef9a647055 schema:name dimensions_id
128 schema:value pub.1048246301
129 rdf:type schema:PropertyValue
130 Nc05a8b8f52374cc1ac1321b74ff67e84 rdf:first sg:person.0702071646.86
131 rdf:rest N8abbb52c80b748edb3f9cd6b9b50186d
132 Nc36416ebd8784e3d9270d2e1ee22bf6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Adult
134 rdf:type schema:DefinedTerm
135 Ncd83405a8c1f4683933910a6e21e9c8b schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 Nd567bab1661241ccb74201e5f50b5d17 schema:name readcube_id
138 schema:value e5d6d914fe63beab562e660d5d4914e2860f517deadc3ea3448abca6c43519a8
139 rdf:type schema:PropertyValue
140 Nd89b016ba87144969895b7f93ecb8afc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Spondylitis, Ankylosing
142 rdf:type schema:DefinedTerm
143 Ned9b8b8abc384ee5beea5a1c075425dd rdf:first sg:person.01070370461.58
144 rdf:rest Nc05a8b8f52374cc1ac1321b74ff67e84
145 Nf367ea2b5cba45b1a7d5f8aa906dfcd9 rdf:first sg:person.01170453603.61
146 rdf:rest Ned9b8b8abc384ee5beea5a1c075425dd
147 Nfd2378bd2142423787bdd4c91ae00051 schema:name pubmed_id
148 schema:value 22576660
149 rdf:type schema:PropertyValue
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
154 schema:name Immunology
155 rdf:type schema:DefinedTerm
156 sg:journal.1093123 schema:issn 0172-8172
157 1437-160X
158 schema:name Rheumatology International
159 rdf:type schema:Periodical
160 sg:person.01070370461.58 schema:affiliation https://www.grid.ac/institutes/grid.9601.e
161 schema:familyName Kucuksezer
162 schema:givenName Umut Can
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070370461.58
164 rdf:type schema:Person
165 sg:person.01170453603.61 schema:affiliation https://www.grid.ac/institutes/grid.9601.e
166 schema:familyName Cosan
167 schema:givenName Fulya
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170453603.61
169 rdf:type schema:Person
170 sg:person.0603062573.29 schema:affiliation https://www.grid.ac/institutes/grid.9601.e
171 schema:familyName Gul
172 schema:givenName Ahmet
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603062573.29
174 rdf:type schema:Person
175 sg:person.0622716501.27 schema:affiliation https://www.grid.ac/institutes/grid.9601.e
176 schema:familyName Deniz
177 schema:givenName Gunnur
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622716501.27
179 rdf:type schema:Person
180 sg:person.0663645744.78 schema:affiliation https://www.grid.ac/institutes/grid.9601.e
181 schema:familyName Cagatay
182 schema:givenName Yonca
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663645744.78
184 rdf:type schema:Person
185 sg:person.0702071646.86 schema:affiliation https://www.grid.ac/institutes/grid.9601.e
186 schema:familyName Bilgic
187 schema:givenName Sema
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702071646.86
189 rdf:type schema:Person
190 sg:person.0704052040.12 schema:affiliation https://www.grid.ac/institutes/grid.9601.e
191 schema:familyName Aktas Cetin
192 schema:givenName Esin
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704052040.12
194 rdf:type schema:Person
195 sg:pub.10.1007/s00296-005-0040-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010913821
196 https://doi.org/10.1007/s00296-005-0040-0
197 rdf:type schema:CreativeWork
198 sg:pub.10.1007/s004030000128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009085358
199 https://doi.org/10.1007/s004030000128
200 rdf:type schema:CreativeWork
201 sg:pub.10.1007/s10067-003-0851-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002655893
202 https://doi.org/10.1007/s10067-003-0851-x
203 rdf:type schema:CreativeWork
204 sg:pub.10.1007/s10067-009-1205-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043757116
205 https://doi.org/10.1007/s10067-009-1205-0
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/ng.624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005574545
208 https://doi.org/10.1038/ng.624
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/ng.625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032813793
211 https://doi.org/10.1038/ng.625
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/ni1254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051485127
214 https://doi.org/10.1038/ni1254
215 rdf:type schema:CreativeWork
216 sg:pub.10.1186/ar2608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010200597
217 https://doi.org/10.1186/ar2608
218 rdf:type schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1074763669 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1074966504 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1077503805 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1078224292 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1082986158 schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1083221903 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1083258057 schema:CreativeWork
226 https://doi.org/10.1016/0167-5699(93)90244-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1000584596
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.ajo.2006.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051729669
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.intimp.2004.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021049298
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.jaci.2010.11.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021717863
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0923-1811(96)00588-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035403248
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1046/j.1365-2249.1997.00299.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031139786
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1046/j.1365-2249.1997.d01-947.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056734185
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1080/03009740600905380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009253458
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1080/03009740701747137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025262870
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1080/09629350220131935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043047450
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1084/jem.174.4.915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028873499
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1093/rheumatology/31.5.299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060010027
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1111/j.1346-8138.1998.tb02372.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010758164
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1111/j.1346-8138.1998.tb02446.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048180665
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1111/j.1346-8138.2003.tb00442.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002154183
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1111/j.1365-2133.1995.tb16946.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000339411
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/j.1365-2230.2004.01684.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043453589
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1111/j.1365-4632.2009.03905.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017700575
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1146/annurev.immunol.17.1.331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041081468
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1155/2011/681956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014113709
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1189/jlb.0603252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016741207
267 rdf:type schema:CreativeWork
268 https://doi.org/10.3109/08916939209148460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014664937
269 rdf:type schema:CreativeWork
270 https://doi.org/10.3129/i07-179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045704997
271 rdf:type schema:CreativeWork
272 https://www.grid.ac/institutes/grid.9601.e schema:alternateName Istanbul University
273 schema:name Department of Immunology, Institute of Experimental Medicine (DETAE), Istanbul University, Vakif Gureba Caddesi, Sehremini, 34393, Istanbul, Turkey
274 Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
275 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...