Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04-13

AUTHORS

Changgui Li, Ying Yuan, Xinfeng Wang, Lin Han, Nan Chu, Hui Wang, Shiguo Liu

ABSTRACT

To identify association of IL18-607 C/A and -137 G/C polymorphism with susceptibility to gout in Chinese Han male population, We evaluate the genetic contribution of the IL18-607 C/A and -137 G/C polymorphism in 202 gout male patients and 493 gout-free control of Chinese Han population by allele-specific polymerase chain reaction assay. Our results reveal no significant association between the polymorphisms -607C/A and -137G/C in IL18 with gout. Our study might suggest that -607 C/A and -137 G/C polymorphisms in the promoter of IL18 are not associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population. More... »

PAGES

1805-1807

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00296-011-1936-5

DOI

http://dx.doi.org/10.1007/s00296-011-1936-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000341537

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21487696


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