Risk factors for avascular bone necrosis in patients with systemic lupus erythematosus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-01

AUTHORS

Mehmet Sayarlioglu, Nergis Yuzbasioglu, Murat Inanc, Sevil Kamali, Ayse Cefle, Ozcan Karaman, Ahmet Mesut Onat, Rustem Avan, Gozde Yildirm Cetin, Ahmet Gul, Lale Ocal, Orhan Aral

ABSTRACT

The objective was to investigate the predictive factors for avascular necrosis (AVN) of bone in patients with systemic lupus erythematosus (SLE). The records of 868 patients with SLE from four centers were reviewed retrospectively. Forty-nine patients with AVN were identified. A total of 154 patients with SLE who did not have clinically apparent AVN during the follow-up were evaluated as a control group. The demographic, clinical, laboratory and management characteristics of these two groups of patients were recorded according to predefined protocol and compared. The prevalence of AVN was detected 6% in our SLE population. The highest dose corticosteroid administered within 4 months and total cumulative prednisolone dose were significantly higher in the SLE patients with AVN. The use of cytotoxic agent significantly higher proportion of patients with AVN. AVN tends to develop more frequently in male gender and younger patients. Oral ulcer, pleuritis, Raynaud's phenomenon, cutaneous vasculitis, lymphadenopathy, autoimmune thyroiditis, peripheral neuropathy and Sjögren's syndrome were higher incidence in SLE patients with AVN. The bilateral femoral heads were the commonest site of involvement of AVN in our patients with SLE. More... »

PAGES

177-182

References to SciGraph publications

  • 2003-07. Osteonecrosis in patients with SLE in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00296-010-1597-9

    DOI

    http://dx.doi.org/10.1007/s00296-010-1597-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051924057

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20711782


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