Autoantibodies in silicosis patients and in silica-exposed individuals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-06

AUTHORS

Gabriel Zaghi, Fábio Koga, Renato M. Nisihara, Thelma L. Skare, Antonieta Handar, Shirley R. Rosa Utiyama, Marilia Barreto Silva

ABSTRACT

The aim of this study was to evaluate the prevalence of autoantibodies in silica-exposed patients with and without silicosis and without any known rheumatic disease. We studied 61 males exposed to silica for a mean time of 12.2 +/- 10.2 years of exposure. A total of 72.1% (44/61) of them presented with pulmonary silicosis. As control group we included 62 healthy males. In all samples we screened for rheumatoid factor (latex agglutination), antinuclear antibodies (indirect immunofluorescence), anti Scl-70 (ELISA) and ANCA (indirect immunofluorescence technique). One patient (1.6%) of the silica group had weakly positive ANA (titer 1:80, centromeric pattern); one (1.6%) had atypical ANCA and seven patients (11.4%) presented positive rheumatoid factor (values range from 8 to 32 UI/ml). One control patient had a positive RF and none of them had positive ANA or ANCA. All patients and controls were negative for anti-Scl-70. The finding of positive RF was higher in the silica-exposed patients (p = 0.032; Fisher). All patients with positive RF had pulmonary silicosis. In the silica-exposed group we could not find a relationship between the presence of RF and age (p = 0.21; Mann-Whitney), smoking habits (p = 0.25; Fisher) but a positive relationship was found with exposure time to silica dust (p = 0.005; Mann-Whitney). We conclude that there was 11.4% prevalence of low titer RF in the silica-exposed patients without known rheumatic disease. RF was more common in patients with longer exposure to silica dust and appeared only in those with silicosis. The presence of ANA, Scl-70 and ANCA was the same as in the control population. More... »

PAGES

1071-1075

References to SciGraph publications

  • 2005-05. Occupational exposure in ANCA-positive patients: A case-control study in KIDNEY INTERNATIONAL
  • 1997-03. ANCA-associated diseases and silica exposure in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • 2002-05. Cytokine polymorphisms in silicosis and other pneumoconioses in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00296-009-1116-z

    DOI

    http://dx.doi.org/10.1007/s00296-009-1116-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038658864

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19705119


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