IkBα promoter polymorphisms in patients with ankylosing spondylitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-04-12

AUTHORS

Yu-Hung Hung, Tsan-Teng Ou, Chia-Hui Lin, Ruei-Nian Li, Yu-Chih Lin, Wen-Chan Tsai, Hong-Wen Liu, Jeng-Hsien Yen

ABSTRACT

The purpose of this study is to investigate the association of IκBα with the development of ankylosing spondylitis (AS) in Taiwan. One hundred and fifty-four patients with AS and 112 unrelated healthy controls were enrolled in this study. The IκBα-881A/G, -826C/T, -550A/T, -519C/T, and -297C/T polymorphisms were determined by the polymerase chain reaction/restriction fragment length polymorphism method. This study demonstrated that the genotype frequencies of IκBα-826C/T and -826T/T, and allele frequencies of IκBα-826T were significantly higher in the patients with AS than in the controls. We also found that the estimated haplotype frequencies of IκBα-881A -826T -550A -519C -297C and IκBα-881A -826C -550A -519T -297C were significantly increased in the patient with AS in comparison with that of the controls. In contrast, the estimated haplotype frequency of IκBα-881A -826C -550A -519C -297C was significantly decreased in the patients with AS. This study demonstrates that IκBα-826T is associated with the development of AS. Furthermore, the IκBα-881A -826T -550A -519C -297C and IκBα-881A -826C -550A -519T -297C haplotypes are related to susceptibility to AS in Taiwan. More... »

PAGES

93-97

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00296-009-0923-6

DOI

http://dx.doi.org/10.1007/s00296-009-0923-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021483681

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19363678


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