Antiphospholipid antibody, head-shaking and ataxia: an evidence of non-vascular neurotoxicity and successful treatment by plasmapheresis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-11-29

AUTHORS

Wei-Hsi Chen, Chung-Jen Chen

ABSTRACT

Although antiphospholipid antibodies (APAbs) are considered to possess neurotoxic property, their relation with non-vascular neurological disorder is still disputed. This dilemma is mainly due to only a cross-sectional analysis or sporadic pictorial description in previous reports. In addition, treatment strategy is unknown in this situation. We encountered a patient who exhibited head-shaking and cerebellar ataxia had an increase of blood anti-beta2-glycoprotein I antibody and anticardiolipin antibody. Her neurological deficits did not respond to corticosteroid pulse therapy but rapidly subsided after plasmapheresis associated with a normalization of APAbs. Accordingly, a causal relation between APAbs and non-vascular neurological disorder is favored. The pathogenesis of APAb-related non-vascular neurotoxicity is warranted for further study to avoid premature conclusion. Plasmapheresis is recommended when movement disorder responds poorly to conventional treatment, especially when APAb is found. More... »

PAGES

827-829

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00296-008-0778-2

DOI

http://dx.doi.org/10.1007/s00296-008-0778-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026432426

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19043718


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