Can tumor necrosis factor receptor II gene 676T>G polymorphism predict the response grading to anti-TNFα therapy in rheumatoid arthritis? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-07

AUTHORS

Alessia Ongaro, Monica De Mattei, Agnese Pellati, Angelo Caruso, Stefano Ferretti, Federica Francesca Masieri, Maria Fotinidi, Ilaria Farina, Francesco Trotta, Melissa Padovan

ABSTRACT

In this study we analyzed whether the polymorphisms 676T>G in the tumor necrosis factor receptor (TNFR) II gene and -308G>A in the TNFalpha promoter gene may influence the response grading to anti-TNFalpha therapy in rheumatoid arthritis. We enrolled and genotyped 105 RA patients treated with etanercept (n = 55), infliximab (n = 40) and adalimumab (n = 10) for 1 year. The clinical response was evaluated according to the ACR criteria every 3 months. Patients with TNFRII 676TG genotype was significantly associated with lower ACR response compared with 676TT genotype, at 3 (OR 3.78 95% CI 1.07-13.31) and 12 months (OR 4.30 95% CI 1.16-15.99) of treatment. No significant association between TNFalpha -308G>A polymorphism and the clinical response was found. TNFRII 676TG genotype is associated with a lower response to anti-TNFalpha therapy, independently from the specific agent used. This polymorphism could become a useful genetic marker for predicting the different response grading to anti-TNFalpha therapy. More... »

PAGES

901-908

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00296-008-0552-5

DOI

http://dx.doi.org/10.1007/s00296-008-0552-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039605921

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18309487


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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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