A comparison of clinical findings of familial Mediterranean fever patients with and without amyloidosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-07-30

AUTHORS

Ayse Cefle, Sevıl Kamali, Mehmet Sayarlioglu, Murat Inanc, Lale Ocal, Orhan Aral, Meral Konice, Ahmet Gul

ABSTRACT

ObjectiveThis study investigates the clinical and demographic characteristics of familial Mediterranean fever (FMF) patients with and without amyloidosis.Patients and methodsThe clinical data of 503 patients with FMF (females:males 250:253) were reviewed. Fifty of these patients had amyloidosis (f:m 23:27).ResultsThe ages of attack onset in patients with and without amyloidosis were 7.8±6.2 and 11.1±8.5, respectively (P<0.05). The time between disease onset and diagnosis was longer in patients with amyloidosis than those without (187.6±99.4 months and 132.5±110.2 months, respectively, P<0.001). More patients in the amyloidosis group had positive family histories of FMF (68% vs 54%, P<0.05). The frequencies of chest pain (78% vs 51%, P<0.001), arthritis ( 80% vs 60%, P<0.01), and erysipelas-like erythema (44% vs 16%, P<0.001) were higher in the amyloidosis group.ConclusionIn the amyloidosis group, FMF-related manifestations of chest pain, arthritis, and erysipelas-like erythema are more frequent. Our results also support that long periods between disease onset and diagnosis are associated with a high risk of developing amyloidosis. More... »

PAGES

442-446

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00296-004-0471-z

DOI

http://dx.doi.org/10.1007/s00296-004-0471-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037413007

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15290087


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