HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-09

AUTHORS

Alberto Sánchez-Díaz, Miguel Blanco, Nic Jones, Sergio Moreno

ABSTRACT

The mammalian HBP2 gene has been isolated by functional complementation of cells unable to undergo DNA replication in fission yeast. HBP2 is a protein with a high mobility group (HMG) domain that belongs to the Sox (Sry-related HMG box) family of transcription factors. As in other members of the family, the HMG box in HBP2 is a DNA-binding domain that is essential for its function in Schizosaccharomyces pombe. Expression of HBP2 in fission yeast activates CdclO-dependent transcription at G1/S and allows growth of cdc10-129, resldelta and rep2delta mutant cells at the restrictive temperature. The mammalian HBP2 activates transcription at G1/S in the fission yeast Sch. pombe. More... »

PAGES

110-118

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002940100241

DOI

http://dx.doi.org/10.1007/s002940100241

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037848979

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11680820


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182 schema:name Instituto de Microbiología Bioquímica, Departamento de Microbiología y Genética, CSIC/Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain
183 rdf:type schema:Organization
 




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