Molecular characterization of U3 small nucleolar RNA from the early diverging protist, Euglena gracilis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-09

AUTHORS

Spencer J. Greenwood, Murray N. Schnare, M. W. Gray

ABSTRACT

U3 small nucleolar RNA (snoRNA) has been isolated from Euglena gracilis, an early diverging protist, and its primary sequence determined. Although this 180-nucleotide-long RNA is considerably smaller than its homolog in vertebrate animals, it contains the conserved sequence blocks (boxes A, Ao, B, C and D) characteristic of U3 snoRNAs from other organisms. A secondary structure can be modelled that displays many of the salient features found in published core structures of vertebrate, yeast and trypanosome U3 snoRNAs. The functional significance of this proposed secondary structure is discussed in relation to the role E. gracilis U3 snoRNA may have in pre-rRNA processing in this organism. Multiple expressed species of E. gracilis U3 snoRNA were found to differ in nucleotide sequence at a number of positions; some of these differences alter pairing in the proposed secondary structure. Analysis of E. gracilis genomic DNA revealed a complex pattern of U3-hybridizing sequences that parallels the multiplicity of expressed species of U3 snoRNA revealed by transcript analysis. More... »

PAGES

338-346

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002940050142

DOI

http://dx.doi.org/10.1007/s002940050142

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035668346

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8781178


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