Ontology type: schema:ScholarlyArticle
2018-12-08
AUTHORSNarottam Acharya, Kodavati Manohar, Doureradjou Peroumal, Prashant Khandagale, Shraddheya Kumar Patel, Satya Ranjan Sahu, Premlata Kumari
ABSTRACTDNA polymerases are evolved to extend the 3'-OH of a growing primer annealed to a template DNA substrate. Since replicative DNA polymerases have a limited role while replicating structurally distorted template, translesion DNA polymerases mostly from Y-family come to the rescue of stalled replication fork and maintain genome stability. DNA polymerase eta is one such specialized enzyme whose function is directly associated with casual development of certain skin cancers and chemo-resistance. More than 20 years of extensive studies are available to support TLS activities of Polη in bypassing various DNA lesions, in addition, limited but crucial growing evidence also exist to suggest Polη possessing TLS-independent cellular functions. In this review, we have mostly focused on non-TLS activities of Polη from different organisms including our recent findings from pathogenic yeast Candida albicans. More... »
PAGES1-8
http://scigraph.springernature.com/pub.10.1007/s00294-018-0918-5
DOIhttp://dx.doi.org/10.1007/s00294-018-0918-5
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30535880
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"description": "DNA polymerases are evolved to extend the 3'-OH of a growing primer annealed to a template DNA substrate. Since replicative DNA polymerases have a limited role while replicating structurally distorted template, translesion DNA polymerases mostly from Y-family come to the rescue of stalled replication fork and maintain genome stability. DNA polymerase eta is one such specialized enzyme whose function is directly associated with casual development of certain skin cancers and chemo-resistance. More than 20\u00a0years of extensive studies are available to support TLS activities of Pol\u03b7 in bypassing various DNA lesions, in addition, limited but crucial growing evidence also exist to suggest Pol\u03b7 possessing TLS-independent cellular functions. In this review, we have mostly focused on non-TLS activities of Pol\u03b7 from different organisms including our recent findings from pathogenic yeast Candida albicans.",
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