Transcription of the mating-type-regulated lncRNA IRT1 is governed by TORC1 and PKA View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05

AUTHORS

Fabien Moretto, Folkert J. van Werven

ABSTRACT

Cell fate decisions are controlled by multiple cell-intrinsic and -extrinsic factors. In budding yeast, the decision to enter gametogenesis or sporulation is dictated by nutrient availability and mating type. Recently, we showed that in diploid cells harbouring opposite mating types (MATa and MATα), the protein kinase A (PKA) and target of rapamycin complex I (TORC1) signalling pathways integrate at the promoter of the master regulatory transcription factor IME1 to control sporulation via nutrient availability (Weidberg, et al. 2016). In cells with a single mating type (MATa or MATα), however, IME1 is repressed by transcription through the IME1 promoter of a long non-coding RNA called IRT1, which prevents this cell type from undergoing sporulation. Here, we investigated the role of nutrient signalling in mating-type control of IME1. We find that expression of IRT1, like IME1 itself, depends on nutrient availability and the activities of PKA and TORC1. IRT1 transcription is repressed when nutrients are ample and TORC1 and PKA are active. In contrast, inhibition of PKA and TORC1 is sufficient to recruit Rme1 to the IRT1 promoter and induce IRT1-mediated repression of IME1. Finally, we provide evidence that IRT1 and IME1 are co-repressed by the Tup1-Cyc8 complex when nutrients are ample. Thus, in cells with a single mating-type nutrient availability regulates mating-type repression of IME1 and sporulation. Our results indicate that there is a hierarchy between nutrient and mating-type signals in controlling the decision to enter sporulation. More... »

PAGES

325-329

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00294-016-0639-6

DOI

http://dx.doi.org/10.1007/s00294-016-0639-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027222386

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27520925


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP-Dependent Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Mating Type, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Long Noncoding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spores, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Cell Fate and Gene Regulation Laboratory, The Francis Crick Institute, 44 Lincoln\u2019s Inn Fields, WC2A 3LY, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moretto", 
        "givenName": "Fabien", 
        "id": "sg:person.01011503763.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011503763.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Cell Fate and Gene Regulation Laboratory, The Francis Crick Institute, 44 Lincoln\u2019s Inn Fields, WC2A 3LY, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Werven", 
        "givenName": "Folkert J.", 
        "id": "sg:person.01104604261.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104604261.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1101/gad.829100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001605200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt1398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005832591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.00460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008517700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.06.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010077089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90146-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012520361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002940050332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015735216", 
          "https://doi.org/10.1007/s002940050332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1006075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017810586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0061(199807)14:10<953::aid-yea293>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026465198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0061(199807)14:10<953::aid-yea293>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026465198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00294-015-0546-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026982272", 
          "https://doi.org/10.1007/s00294-015-0546-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/319738a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030020403", 
          "https://doi.org/10.1038/319738a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2011.0081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030307280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.09.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034154123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(00)00104-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040060646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0074-7696(05)24004-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042133891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0074-7696(05)24004-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042133891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(88)90427-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042794625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/369758a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049337907", 
          "https://doi.org/10.1038/369758a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.7.8.1598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051473680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.179275.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053194614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1995.tb00270.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082974013"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-05", 
    "datePublishedReg": "2017-05-01", 
    "description": "Cell fate decisions are controlled by multiple cell-intrinsic and -extrinsic factors. In budding yeast, the decision to enter gametogenesis or sporulation is dictated by nutrient availability and mating type. Recently, we showed that in diploid cells harbouring opposite mating types (MATa and MAT\u03b1), the protein kinase A (PKA) and target of rapamycin complex I (TORC1) signalling pathways integrate at the promoter of the master regulatory transcription factor IME1 to control sporulation via nutrient availability (Weidberg, et al. 2016). In cells with a single mating type (MATa or MAT\u03b1), however, IME1 is repressed by transcription through the IME1 promoter of a long non-coding RNA called IRT1, which prevents this cell type from undergoing sporulation. Here, we investigated the role of nutrient signalling in mating-type control of IME1. We find that expression of IRT1, like IME1 itself, depends on nutrient availability and the activities of PKA and TORC1. IRT1 transcription is repressed when nutrients are ample and TORC1 and PKA are active. In contrast, inhibition of PKA and TORC1 is sufficient to recruit Rme1 to the IRT1 promoter and induce IRT1-mediated repression of IME1. Finally, we provide evidence that IRT1 and IME1 are co-repressed by the Tup1-Cyc8 complex when nutrients are ample. Thus, in cells with a single mating-type nutrient availability regulates mating-type repression of IME1 and sporulation. Our results indicate that there is a hierarchy between nutrient and mating-type signals in controlling the decision to enter sporulation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00294-016-0639-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6798152", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1091193", 
        "issn": [
          "0172-8083", 
          "1432-0983"
        ], 
        "name": "Current Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "63"
      }
    ], 
    "name": "Transcription of the mating-type-regulated lncRNA IRT1 is governed by TORC1 and PKA", 
    "pagination": "325-329", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "81ad11452540a573842311392456366bf7d02b5439a97eac482b21be59afffa9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27520925"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8004904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00294-016-0639-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027222386"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00294-016-0639-6", 
      "https://app.dimensions.ai/details/publication/pub.1027222386"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000513.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00294-016-0639-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00294-016-0639-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00294-016-0639-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00294-016-0639-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00294-016-0639-6'


 

This table displays all metadata directly associated to this object as RDF triples.

203 TRIPLES      21 PREDICATES      64 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00294-016-0639-6 schema:about N006e37558bcd47bba9ef4828a4da8b5c
2 N205d33ac823a4cf4af29f8114512c168
3 N28e3ffa0114f481e85b790e04ddb5b7f
4 N2a827dcf72bd47ee9c31745c67961121
5 N526ae130b14b4a4f84b427f477b2e232
6 N64da602d1be943cfb6d7dbb869b63381
7 N7438a948d23a401ba5bf8ca82ead8854
8 N94572a836eb347e5ad9042191ec75e75
9 N9897197490ef4ae88df12d7898229866
10 N99d1638e929e41428beff31b699ec0bd
11 Na35a86fb8e4f4bad8573da7ece95f06b
12 Naa3524ca93be400db42781684de990f8
13 Ncd78cb8e42d044d6a5b61b4728262fad
14 Nd12f728e2c3b4802a008b96ae1287f74
15 Ndc9d1c28d9e945a2877a22c3473a6825
16 Nf21a71718bbb4cc6b75d65a6b9100d33
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author Nc865f243af854d598f44151e955f1698
20 schema:citation sg:pub.10.1007/s00294-015-0546-2
21 sg:pub.10.1007/s002940050332
22 sg:pub.10.1038/319738a0
23 sg:pub.10.1038/369758a0
24 https://doi.org/10.1002/(sici)1097-0061(199807)14:10<953::aid-yea293>3.0.co;2-u
25 https://doi.org/10.1002/j.1460-2075.1995.tb00270.x
26 https://doi.org/10.1016/0092-8674(88)90427-8
27 https://doi.org/10.1016/0092-8674(92)90146-4
28 https://doi.org/10.1016/j.cell.2007.09.044
29 https://doi.org/10.1016/j.cell.2012.06.049
30 https://doi.org/10.1016/s0074-7696(05)24004-4
31 https://doi.org/10.1016/s0955-0674(00)00104-6
32 https://doi.org/10.1093/nar/gkt1398
33 https://doi.org/10.1098/rstb.2011.0081
34 https://doi.org/10.1101/gad.179275.111
35 https://doi.org/10.1101/gad.7.8.1598
36 https://doi.org/10.1101/gad.829100
37 https://doi.org/10.1242/jcs.00460
38 https://doi.org/10.1371/journal.pgen.1006075
39 schema:datePublished 2017-05
40 schema:datePublishedReg 2017-05-01
41 schema:description Cell fate decisions are controlled by multiple cell-intrinsic and -extrinsic factors. In budding yeast, the decision to enter gametogenesis or sporulation is dictated by nutrient availability and mating type. Recently, we showed that in diploid cells harbouring opposite mating types (MATa and MATα), the protein kinase A (PKA) and target of rapamycin complex I (TORC1) signalling pathways integrate at the promoter of the master regulatory transcription factor IME1 to control sporulation via nutrient availability (Weidberg, et al. 2016). In cells with a single mating type (MATa or MATα), however, IME1 is repressed by transcription through the IME1 promoter of a long non-coding RNA called IRT1, which prevents this cell type from undergoing sporulation. Here, we investigated the role of nutrient signalling in mating-type control of IME1. We find that expression of IRT1, like IME1 itself, depends on nutrient availability and the activities of PKA and TORC1. IRT1 transcription is repressed when nutrients are ample and TORC1 and PKA are active. In contrast, inhibition of PKA and TORC1 is sufficient to recruit Rme1 to the IRT1 promoter and induce IRT1-mediated repression of IME1. Finally, we provide evidence that IRT1 and IME1 are co-repressed by the Tup1-Cyc8 complex when nutrients are ample. Thus, in cells with a single mating-type nutrient availability regulates mating-type repression of IME1 and sporulation. Our results indicate that there is a hierarchy between nutrient and mating-type signals in controlling the decision to enter sporulation.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree true
45 schema:isPartOf N61efcd84511445f383070e3d76ddd702
46 Nddca1c30d06b4a12a8c21d016a98b4d5
47 sg:journal.1091193
48 schema:name Transcription of the mating-type-regulated lncRNA IRT1 is governed by TORC1 and PKA
49 schema:pagination 325-329
50 schema:productId N11ebd4be7ad14c699d3a9cc259f62f09
51 N1ccade23a98848e68a773b950e3ebfd0
52 N4fcb2db775cb4e56800fce600094df49
53 Ncd4bc9a05dcd4586bd886bf67a62cc24
54 Ne9041bbdda394a09af76b24ceaf46c20
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027222386
56 https://doi.org/10.1007/s00294-016-0639-6
57 schema:sdDatePublished 2019-04-11T01:07
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N033009863efa4d9b9fac3a33f3ab53b7
60 schema:url http://link.springer.com/10.1007%2Fs00294-016-0639-6
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N006e37558bcd47bba9ef4828a4da8b5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Saccharomyces cerevisiae
66 rdf:type schema:DefinedTerm
67 N033009863efa4d9b9fac3a33f3ab53b7 schema:name Springer Nature - SN SciGraph project
68 rdf:type schema:Organization
69 N11ebd4be7ad14c699d3a9cc259f62f09 schema:name pubmed_id
70 schema:value 27520925
71 rdf:type schema:PropertyValue
72 N1ccade23a98848e68a773b950e3ebfd0 schema:name dimensions_id
73 schema:value pub.1027222386
74 rdf:type schema:PropertyValue
75 N205d33ac823a4cf4af29f8114512c168 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Spores, Fungal
77 rdf:type schema:DefinedTerm
78 N28e3ffa0114f481e85b790e04ddb5b7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Saccharomyces cerevisiae Proteins
80 rdf:type schema:DefinedTerm
81 N2a827dcf72bd47ee9c31745c67961121 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Transcription, Genetic
83 rdf:type schema:DefinedTerm
84 N4fcb2db775cb4e56800fce600094df49 schema:name nlm_unique_id
85 schema:value 8004904
86 rdf:type schema:PropertyValue
87 N526ae130b14b4a4f84b427f477b2e232 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Mutation
89 rdf:type schema:DefinedTerm
90 N61efcd84511445f383070e3d76ddd702 schema:volumeNumber 63
91 rdf:type schema:PublicationVolume
92 N64da602d1be943cfb6d7dbb869b63381 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Nuclear Proteins
94 rdf:type schema:DefinedTerm
95 N7438a948d23a401ba5bf8ca82ead8854 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Repressor Proteins
97 rdf:type schema:DefinedTerm
98 N94572a836eb347e5ad9042191ec75e75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Genes, Mating Type, Fungal
100 rdf:type schema:DefinedTerm
101 N9897197490ef4ae88df12d7898229866 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Transcription Factors
103 rdf:type schema:DefinedTerm
104 N99d1638e929e41428beff31b699ec0bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Promoter Regions, Genetic
106 rdf:type schema:DefinedTerm
107 Na35a86fb8e4f4bad8573da7ece95f06b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Models, Genetic
109 rdf:type schema:DefinedTerm
110 Na881d873e6914f208fa4b515fe010a8a rdf:first sg:person.01104604261.01
111 rdf:rest rdf:nil
112 Naa3524ca93be400db42781684de990f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name RNA, Long Noncoding
114 rdf:type schema:DefinedTerm
115 Nc865f243af854d598f44151e955f1698 rdf:first sg:person.01011503763.66
116 rdf:rest Na881d873e6914f208fa4b515fe010a8a
117 Ncd4bc9a05dcd4586bd886bf67a62cc24 schema:name doi
118 schema:value 10.1007/s00294-016-0639-6
119 rdf:type schema:PropertyValue
120 Ncd78cb8e42d044d6a5b61b4728262fad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Gene Expression Regulation, Fungal
122 rdf:type schema:DefinedTerm
123 Nd12f728e2c3b4802a008b96ae1287f74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Cyclic AMP-Dependent Protein Kinases
125 rdf:type schema:DefinedTerm
126 Ndc9d1c28d9e945a2877a22c3473a6825 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Signal Transduction
128 rdf:type schema:DefinedTerm
129 Nddca1c30d06b4a12a8c21d016a98b4d5 schema:issueNumber 2
130 rdf:type schema:PublicationIssue
131 Ne9041bbdda394a09af76b24ceaf46c20 schema:name readcube_id
132 schema:value 81ad11452540a573842311392456366bf7d02b5439a97eac482b21be59afffa9
133 rdf:type schema:PropertyValue
134 Nf21a71718bbb4cc6b75d65a6b9100d33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Reverse Transcriptase Polymerase Chain Reaction
136 rdf:type schema:DefinedTerm
137 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
138 schema:name Biological Sciences
139 rdf:type schema:DefinedTerm
140 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
141 schema:name Biochemistry and Cell Biology
142 rdf:type schema:DefinedTerm
143 sg:grant.6798152 http://pending.schema.org/fundedItem sg:pub.10.1007/s00294-016-0639-6
144 rdf:type schema:MonetaryGrant
145 sg:journal.1091193 schema:issn 0172-8083
146 1432-0983
147 schema:name Current Genetics
148 rdf:type schema:Periodical
149 sg:person.01011503763.66 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
150 schema:familyName Moretto
151 schema:givenName Fabien
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011503763.66
153 rdf:type schema:Person
154 sg:person.01104604261.01 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
155 schema:familyName van Werven
156 schema:givenName Folkert J.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104604261.01
158 rdf:type schema:Person
159 sg:pub.10.1007/s00294-015-0546-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026982272
160 https://doi.org/10.1007/s00294-015-0546-2
161 rdf:type schema:CreativeWork
162 sg:pub.10.1007/s002940050332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015735216
163 https://doi.org/10.1007/s002940050332
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/319738a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030020403
166 https://doi.org/10.1038/319738a0
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/369758a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049337907
169 https://doi.org/10.1038/369758a0
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1002/(sici)1097-0061(199807)14:10<953::aid-yea293>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1026465198
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1002/j.1460-2075.1995.tb00270.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082974013
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/0092-8674(88)90427-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042794625
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/0092-8674(92)90146-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012520361
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.cell.2007.09.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034154123
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.cell.2012.06.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010077089
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/s0074-7696(05)24004-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042133891
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/s0955-0674(00)00104-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040060646
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1093/nar/gkt1398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005832591
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1098/rstb.2011.0081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030307280
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1101/gad.179275.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053194614
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1101/gad.7.8.1598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051473680
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1101/gad.829100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001605200
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1242/jcs.00460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008517700
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1371/journal.pgen.1006075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017810586
200 rdf:type schema:CreativeWork
201 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
202 schema:name Cell Fate and Gene Regulation Laboratory, The Francis Crick Institute, 44 Lincoln’s Inn Fields, WC2A 3LY, London, UK
203 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...