Recent insights into Candida albicans biofilm resistance mechanisms View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-08-25

AUTHORS

Lotte Mathé, Patrick Van Dijck

ABSTRACT

Like other microorganisms, free-living Candida albicans is mainly present in a three-dimensional multicellular structure, which is called a biofilm, rather than in a planktonic form. Candida albicans biofilms can be isolated from both abiotic and biotic surfaces at various locations within the host. As the number of abiotic implants, mainly bloodstream and urinary catheters, has been increasing, the number of biofilm-associated bloodstream or urogenital tract infections is also strongly increasing resulting in a raise in mortality. Cells within a biofilm structure show a reduced susceptibility to specific commonly used antifungals and, in addition, it has recently been shown that such cells are less sensitive to killing by components of our immune system. In this review, we summarize the most important insights in the mechanisms underlying biofilm-associated antifungal drug resistance and immune evasion strategies, focusing on the most recent advances in this area of research. More... »

PAGES

251-264

References to SciGraph publications

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  • 1995-03. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals in CURRENT GENETICS
  • 2009-12-13. Presence of Extracellular DNA in the Candida albicans Biofilm Matrix and its Contribution to Biofilms in MYCOPATHOLOGIA
  • 2010-04-17. In Vitro Biofilm Activity of Non-Candida albicansCandida Species in CURRENT MICROBIOLOGY
  • 2010-08-20. An insight into the antifungal pipeline: selected new molecules and beyond in NATURE REVIEWS DRUG DISCOVERY
  • 2012-10-04. Sensitization of Candida albicans biofilms to various antifungal drugs by cyclosporine A in ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
  • 1991-06. Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate in MOLECULAR GENETICS AND GENOMICS
  • 2011-04. Candida albicans, a major human fungal pathogen in JOURNAL OF MICROBIOLOGY
  • 2009-04-16. Design of a Simple Model of Candida albicans Biofilms Formed under Conditions of Flow: Development, Architecture, and Drug Resistance in MYCOPATHOLOGIA
  • 2012-08-07. Persister Cells: Molecular Mechanisms Related to Antibiotic Tolerance in ANTIBIOTIC RESISTANCE
  • 2010-04-16. Real-time PCR expression profiling of genes encoding potential virulence factors in Candida albicans biofilms: identification of model-dependent and -independent gene expression in BMC MICROBIOLOGY
  • 2002-12-01. Candida albicans: A molecular revolution built on lessons from budding yeast in NATURE REVIEWS GENETICS
  • 2012-01. Sensing of mammalian IL-17A regulates fungal adaptation and virulence in NATURE COMMUNICATIONS
  • 2006-06-14. Attributable mortality of candidemia: a systematic review of matched cohort and case-control studies in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2010-12-29. Genetic control of Candida albicans biofilm development in NATURE REVIEWS MICROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00294-013-0400-3

    DOI

    http://dx.doi.org/10.1007/s00294-013-0400-3

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23974350


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