Recent insights into Candida albicans biofilm resistance mechanisms View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-08-25

AUTHORS

Lotte Mathé, Patrick Van Dijck

ABSTRACT

Like other microorganisms, free-living Candida albicans is mainly present in a three-dimensional multicellular structure, which is called a biofilm, rather than in a planktonic form. Candida albicans biofilms can be isolated from both abiotic and biotic surfaces at various locations within the host. As the number of abiotic implants, mainly bloodstream and urinary catheters, has been increasing, the number of biofilm-associated bloodstream or urogenital tract infections is also strongly increasing resulting in a raise in mortality. Cells within a biofilm structure show a reduced susceptibility to specific commonly used antifungals and, in addition, it has recently been shown that such cells are less sensitive to killing by components of our immune system. In this review, we summarize the most important insights in the mechanisms underlying biofilm-associated antifungal drug resistance and immune evasion strategies, focusing on the most recent advances in this area of research. More... »

PAGES

251-264

References to SciGraph publications

  • 2008-01. An integrated model of the recognition of Candida albicans by the innate immune system in NATURE REVIEWS MICROBIOLOGY
  • 1995-03. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals in CURRENT GENETICS
  • 2009-12-13. Presence of Extracellular DNA in the Candida albicans Biofilm Matrix and its Contribution to Biofilms in MYCOPATHOLOGIA
  • 2010-04-17. In Vitro Biofilm Activity of Non-Candida albicansCandida Species in CURRENT MICROBIOLOGY
  • 2010-08-20. An insight into the antifungal pipeline: selected new molecules and beyond in NATURE REVIEWS DRUG DISCOVERY
  • 2012-10-04. Sensitization of Candida albicans biofilms to various antifungal drugs by cyclosporine A in ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
  • 1991-06. Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate in MOLECULAR GENETICS AND GENOMICS
  • 2011-04. Candida albicans, a major human fungal pathogen in JOURNAL OF MICROBIOLOGY
  • 2009-04-16. Design of a Simple Model of Candida albicans Biofilms Formed under Conditions of Flow: Development, Architecture, and Drug Resistance in MYCOPATHOLOGIA
  • 2012-08-07. Persister Cells: Molecular Mechanisms Related to Antibiotic Tolerance in ANTIBIOTIC RESISTANCE
  • 2010-04-16. Real-time PCR expression profiling of genes encoding potential virulence factors in Candida albicans biofilms: identification of model-dependent and -independent gene expression in BMC MICROBIOLOGY
  • 2002-12-01. Candida albicans: A molecular revolution built on lessons from budding yeast in NATURE REVIEWS GENETICS
  • 2012-01. Sensing of mammalian IL-17A regulates fungal adaptation and virulence in NATURE COMMUNICATIONS
  • 2006-06-14. Attributable mortality of candidemia: a systematic review of matched cohort and case-control studies in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2010-12-29. Genetic control of Candida albicans biofilm development in NATURE REVIEWS MICROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00294-013-0400-3

    DOI

    http://dx.doi.org/10.1007/s00294-013-0400-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041466232

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23974350


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antifungal Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biofilms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Candida albicans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Candidiasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Resistance, Fungal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Fungal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immune Evasion", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Laboratory of Molecular Cell Biology, KU Leuven, Kasteelpark Arenberg 31 bus 2438, Heverlee, 3001, Leuven, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Department of Molecular Microbiology, VIB, Leuven, Belgium", 
                "Laboratory of Molecular Cell Biology, KU Leuven, Kasteelpark Arenberg 31 bus 2438, Heverlee, 3001, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Math\u00e9", 
            "givenName": "Lotte", 
            "id": "sg:person.0714754512.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714754512.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Molecular Cell Biology, KU Leuven, Kasteelpark Arenberg 31 bus 2438, Heverlee, 3001, Leuven, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Department of Molecular Microbiology, VIB, Leuven, Belgium", 
                "Laboratory of Molecular Cell Biology, KU Leuven, Kasteelpark Arenberg 31 bus 2438, Heverlee, 3001, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Van Dijck", 
            "givenName": "Patrick", 
            "id": "sg:person.01010124306.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010124306.14"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s12275-011-1064-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022985201", 
              "https://doi.org/10.1007/s12275-011-1064-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms1685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049677693", 
              "https://doi.org/10.1038/ncomms1685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00284-010-9649-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024257928", 
              "https://doi.org/10.1007/s00284-010-9649-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00259685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028908731", 
              "https://doi.org/10.1007/bf00259685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-28951-4_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023475589", 
              "https://doi.org/10.1007/978-3-642-28951-4_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg948", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044061581", 
              "https://doi.org/10.1038/nrg948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11046-009-9205-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011112425", 
              "https://doi.org/10.1007/s11046-009-9205-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro1815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000786279", 
              "https://doi.org/10.1038/nrmicro1815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11046-009-9264-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043622485", 
              "https://doi.org/10.1007/s11046-009-9264-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2180-10-114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019232837", 
              "https://doi.org/10.1186/1471-2180-10-114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-006-0159-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044049473", 
              "https://doi.org/10.1007/s10096-006-0159-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00352101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030723490", 
              "https://doi.org/10.1007/bf00352101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro2475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008253908", 
              "https://doi.org/10.1038/nrmicro2475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-0711-11-27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031957341", 
              "https://doi.org/10.1186/1476-0711-11-27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007775546", 
              "https://doi.org/10.1038/nrd3074"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-08-25", 
        "datePublishedReg": "2013-08-25", 
        "description": "Like other microorganisms, free-living Candida albicans is mainly present in a three-dimensional multicellular structure, which is called a biofilm, rather than in a planktonic form. Candida albicans biofilms can be isolated from both abiotic and biotic surfaces at various locations within the host. As the number of abiotic implants, mainly bloodstream and urinary catheters, has been increasing, the number of biofilm-associated bloodstream or urogenital tract infections is also strongly increasing resulting in a raise in mortality. Cells within a biofilm structure show a reduced susceptibility to specific commonly used antifungals and, in addition, it has recently been shown that such cells are less sensitive to killing by components of our immune system. In this review, we summarize the most important insights in the mechanisms underlying biofilm-associated antifungal drug resistance and immune evasion strategies, focusing on the most recent advances in this area of research.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00294-013-0400-3", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6770054", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1091193", 
            "issn": [
              "0172-8083", 
              "1432-0983"
            ], 
            "name": "Current Genetics", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "59"
          }
        ], 
        "keywords": [
          "urogenital tract infections", 
          "immune evasion strategies", 
          "tract infections", 
          "biofilm resistance mechanisms", 
          "urinary catheter", 
          "immune system", 
          "antifungal drug resistance", 
          "evasion strategies", 
          "drug resistance", 
          "number of biofilms", 
          "reduced susceptibility", 
          "such cells", 
          "resistance mechanisms", 
          "bloodstream", 
          "Candida albicans biofilms", 
          "recent insights", 
          "Candida albicans", 
          "cells", 
          "catheter", 
          "albicans biofilms", 
          "infection", 
          "mortality", 
          "planktonic form", 
          "antifungals", 
          "recent advances", 
          "implants", 
          "three-dimensional multicellular structures", 
          "review", 
          "albicans", 
          "susceptibility", 
          "mechanism", 
          "biofilms", 
          "important insights", 
          "area of research", 
          "number", 
          "biotic surfaces", 
          "resistance", 
          "host", 
          "biofilm structure", 
          "advances", 
          "raise", 
          "addition", 
          "strategies", 
          "insights", 
          "area", 
          "microorganisms", 
          "location", 
          "components", 
          "research", 
          "form", 
          "multicellular structures", 
          "system", 
          "structure", 
          "surface"
        ], 
        "name": "Recent insights into Candida albicans biofilm resistance mechanisms", 
        "pagination": "251-264", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1041466232"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00294-013-0400-3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23974350"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00294-013-0400-3", 
          "https://app.dimensions.ai/details/publication/pub.1041466232"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:00", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_604.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00294-013-0400-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00294-013-0400-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00294-013-0400-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00294-013-0400-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00294-013-0400-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    221 TRIPLES      21 PREDICATES      103 URIs      79 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00294-013-0400-3 schema:about N0024b5ef220441b4b0276e6bff07a811
    2 N2a61e8c6fa564ab7a9485ca56963656f
    3 N2e78a6c6dba94f8199d790d6fa3eb87e
    4 N4a502b9cf9dd4d6eaa5e3fd066d4a8b2
    5 Naeb8a03d32574430a05d897da5d83f8a
    6 Nb66aa06330b74069a3f7de6e56cfe979
    7 Nd1eaca935a4e47bfa5e66fcdb5e95f5d
    8 Nf235ca72172a4e12943a5f194458cfbd
    9 anzsrc-for:06
    10 anzsrc-for:0604
    11 anzsrc-for:0605
    12 schema:author Nddccadea0285494ebaa81b8127ecf7d2
    13 schema:citation sg:pub.10.1007/978-3-642-28951-4_8
    14 sg:pub.10.1007/bf00259685
    15 sg:pub.10.1007/bf00352101
    16 sg:pub.10.1007/s00284-010-9649-7
    17 sg:pub.10.1007/s10096-006-0159-2
    18 sg:pub.10.1007/s11046-009-9205-9
    19 sg:pub.10.1007/s11046-009-9264-y
    20 sg:pub.10.1007/s12275-011-1064-7
    21 sg:pub.10.1038/ncomms1685
    22 sg:pub.10.1038/nrd3074
    23 sg:pub.10.1038/nrg948
    24 sg:pub.10.1038/nrmicro1815
    25 sg:pub.10.1038/nrmicro2475
    26 sg:pub.10.1186/1471-2180-10-114
    27 sg:pub.10.1186/1476-0711-11-27
    28 schema:datePublished 2013-08-25
    29 schema:datePublishedReg 2013-08-25
    30 schema:description Like other microorganisms, free-living Candida albicans is mainly present in a three-dimensional multicellular structure, which is called a biofilm, rather than in a planktonic form. Candida albicans biofilms can be isolated from both abiotic and biotic surfaces at various locations within the host. As the number of abiotic implants, mainly bloodstream and urinary catheters, has been increasing, the number of biofilm-associated bloodstream or urogenital tract infections is also strongly increasing resulting in a raise in mortality. Cells within a biofilm structure show a reduced susceptibility to specific commonly used antifungals and, in addition, it has recently been shown that such cells are less sensitive to killing by components of our immune system. In this review, we summarize the most important insights in the mechanisms underlying biofilm-associated antifungal drug resistance and immune evasion strategies, focusing on the most recent advances in this area of research.
    31 schema:genre article
    32 schema:isAccessibleForFree true
    33 schema:isPartOf N4987d95785c14e87acdadf0d0161892c
    34 Nc43379c6831d464683f2c9b6e59f8af1
    35 sg:journal.1091193
    36 schema:keywords Candida albicans
    37 Candida albicans biofilms
    38 addition
    39 advances
    40 albicans
    41 albicans biofilms
    42 antifungal drug resistance
    43 antifungals
    44 area
    45 area of research
    46 biofilm resistance mechanisms
    47 biofilm structure
    48 biofilms
    49 biotic surfaces
    50 bloodstream
    51 catheter
    52 cells
    53 components
    54 drug resistance
    55 evasion strategies
    56 form
    57 host
    58 immune evasion strategies
    59 immune system
    60 implants
    61 important insights
    62 infection
    63 insights
    64 location
    65 mechanism
    66 microorganisms
    67 mortality
    68 multicellular structures
    69 number
    70 number of biofilms
    71 planktonic form
    72 raise
    73 recent advances
    74 recent insights
    75 reduced susceptibility
    76 research
    77 resistance
    78 resistance mechanisms
    79 review
    80 strategies
    81 structure
    82 such cells
    83 surface
    84 susceptibility
    85 system
    86 three-dimensional multicellular structures
    87 tract infections
    88 urinary catheter
    89 urogenital tract infections
    90 schema:name Recent insights into Candida albicans biofilm resistance mechanisms
    91 schema:pagination 251-264
    92 schema:productId N3c5a0f29da554e4d997a57762834e8da
    93 Nc1df6fb2fd874079aa7926ee2cc3fb5a
    94 Nf85acecec8834e859c77908f4895dae7
    95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041466232
    96 https://doi.org/10.1007/s00294-013-0400-3
    97 schema:sdDatePublished 2022-08-04T17:00
    98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    99 schema:sdPublisher N075175e324f94ee5bb8cda105b9ba7d0
    100 schema:url https://doi.org/10.1007/s00294-013-0400-3
    101 sgo:license sg:explorer/license/
    102 sgo:sdDataset articles
    103 rdf:type schema:ScholarlyArticle
    104 N0024b5ef220441b4b0276e6bff07a811 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Antifungal Agents
    106 rdf:type schema:DefinedTerm
    107 N075175e324f94ee5bb8cda105b9ba7d0 schema:name Springer Nature - SN SciGraph project
    108 rdf:type schema:Organization
    109 N2a61e8c6fa564ab7a9485ca56963656f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Gene Expression Regulation, Fungal
    111 rdf:type schema:DefinedTerm
    112 N2e78a6c6dba94f8199d790d6fa3eb87e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Humans
    114 rdf:type schema:DefinedTerm
    115 N3c5a0f29da554e4d997a57762834e8da schema:name pubmed_id
    116 schema:value 23974350
    117 rdf:type schema:PropertyValue
    118 N4987d95785c14e87acdadf0d0161892c schema:issueNumber 4
    119 rdf:type schema:PublicationIssue
    120 N4a502b9cf9dd4d6eaa5e3fd066d4a8b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Drug Resistance, Fungal
    122 rdf:type schema:DefinedTerm
    123 Naeb8a03d32574430a05d897da5d83f8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Biofilms
    125 rdf:type schema:DefinedTerm
    126 Nb172f6380b7f4cd2b3125f7cfccc2d18 rdf:first sg:person.01010124306.14
    127 rdf:rest rdf:nil
    128 Nb66aa06330b74069a3f7de6e56cfe979 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Candidiasis
    130 rdf:type schema:DefinedTerm
    131 Nc1df6fb2fd874079aa7926ee2cc3fb5a schema:name dimensions_id
    132 schema:value pub.1041466232
    133 rdf:type schema:PropertyValue
    134 Nc43379c6831d464683f2c9b6e59f8af1 schema:volumeNumber 59
    135 rdf:type schema:PublicationVolume
    136 Nd1eaca935a4e47bfa5e66fcdb5e95f5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Candida albicans
    138 rdf:type schema:DefinedTerm
    139 Nddccadea0285494ebaa81b8127ecf7d2 rdf:first sg:person.0714754512.30
    140 rdf:rest Nb172f6380b7f4cd2b3125f7cfccc2d18
    141 Nf235ca72172a4e12943a5f194458cfbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Immune Evasion
    143 rdf:type schema:DefinedTerm
    144 Nf85acecec8834e859c77908f4895dae7 schema:name doi
    145 schema:value 10.1007/s00294-013-0400-3
    146 rdf:type schema:PropertyValue
    147 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    148 schema:name Biological Sciences
    149 rdf:type schema:DefinedTerm
    150 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    151 schema:name Genetics
    152 rdf:type schema:DefinedTerm
    153 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
    154 schema:name Microbiology
    155 rdf:type schema:DefinedTerm
    156 sg:grant.6770054 http://pending.schema.org/fundedItem sg:pub.10.1007/s00294-013-0400-3
    157 rdf:type schema:MonetaryGrant
    158 sg:journal.1091193 schema:issn 0172-8083
    159 1432-0983
    160 schema:name Current Genetics
    161 schema:publisher Springer Nature
    162 rdf:type schema:Periodical
    163 sg:person.01010124306.14 schema:affiliation grid-institutes:grid.5596.f
    164 schema:familyName Van Dijck
    165 schema:givenName Patrick
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010124306.14
    167 rdf:type schema:Person
    168 sg:person.0714754512.30 schema:affiliation grid-institutes:grid.5596.f
    169 schema:familyName Mathé
    170 schema:givenName Lotte
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714754512.30
    172 rdf:type schema:Person
    173 sg:pub.10.1007/978-3-642-28951-4_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023475589
    174 https://doi.org/10.1007/978-3-642-28951-4_8
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1007/bf00259685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028908731
    177 https://doi.org/10.1007/bf00259685
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1007/bf00352101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030723490
    180 https://doi.org/10.1007/bf00352101
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1007/s00284-010-9649-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024257928
    183 https://doi.org/10.1007/s00284-010-9649-7
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1007/s10096-006-0159-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044049473
    186 https://doi.org/10.1007/s10096-006-0159-2
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1007/s11046-009-9205-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011112425
    189 https://doi.org/10.1007/s11046-009-9205-9
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1007/s11046-009-9264-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1043622485
    192 https://doi.org/10.1007/s11046-009-9264-y
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1007/s12275-011-1064-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022985201
    195 https://doi.org/10.1007/s12275-011-1064-7
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/ncomms1685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049677693
    198 https://doi.org/10.1038/ncomms1685
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/nrd3074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007775546
    201 https://doi.org/10.1038/nrd3074
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/nrg948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044061581
    204 https://doi.org/10.1038/nrg948
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/nrmicro1815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000786279
    207 https://doi.org/10.1038/nrmicro1815
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/nrmicro2475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008253908
    210 https://doi.org/10.1038/nrmicro2475
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1186/1471-2180-10-114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019232837
    213 https://doi.org/10.1186/1471-2180-10-114
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1186/1476-0711-11-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031957341
    216 https://doi.org/10.1186/1476-0711-11-27
    217 rdf:type schema:CreativeWork
    218 grid-institutes:grid.5596.f schema:alternateName Laboratory of Molecular Cell Biology, KU Leuven, Kasteelpark Arenberg 31 bus 2438, Heverlee, 3001, Leuven, Belgium
    219 schema:name Department of Molecular Microbiology, VIB, Leuven, Belgium
    220 Laboratory of Molecular Cell Biology, KU Leuven, Kasteelpark Arenberg 31 bus 2438, Heverlee, 3001, Leuven, Belgium
    221 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...