Prädiktive PD-L1-Immunhistochemie beim nichtkleinzelligen Bronchialkarzinom View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11

AUTHORS

A. H. Scheel, M. Dietel, L. C. Heukamp, K. Jöhrens, T. Kirchner, S. Reu, J. Rüschoff, H. U. Schildhaus, P. Schirmacher, M. Tiemann, A. Warth, W. Weichert, R. N. Fischer, J. Wolf, R. Büttner

ABSTRACT

BACKGROUND: Antibodies against PD-1 and PD-L1 can cause strong and durable anti-tumor immune responses in non-small cell lung cancer (NSCLC). Immunohistochemistry for PD-L1 (PD-L1 IHC) was tested as a predictive biomarker. Several IHC assays and interpretation criteria were developed in parallel. AIM: The clinical significance of PD-L1 IHC in NSCLC and the optimum method for staining and interpretation of the results are the subject of ongoing studies. The diagnostic application of immunotherapy in NSCLC necessitates harmonization of PD-L1 IHC to obtain evidence for guidelines; therefore, a consensus opinion on a well-founded diagnostic mode of testing should be defined based on published studies and the results of the first German PD-L1 IHC harmonization study. METHODS: 1. Summary of the current data situation. 2. Evaluation of the first German PD-L1 IHC harmonization study (centralized, staining with PD-L1 IHC analogous to studies, 15 cases of NSCLC, 4 IHC study assays [28‑8, 22C3, SP142 and SP263] and scoring by 9 pathologists). RESULTS: The use of PD-L1 IHC in NSCLC is suitable for identification of patients with an increased probability of a clinical benefit from immunotherapy. The various proportional cut-offs used to interpret the staining results can be summarized in a total score, which can be reproducibly assessed. The staining patterns of the four assays investigated were, however, not congruent in all situations. DISCUSSION: In principle, the use of PD-L1 IHC for assessment of the expression in tumor cells is a reliably determinable biomarker. Evaluation algorithms should be based on published clinical trials. For NSCLC approvals with obligatory PD-L1 IHC are to be expected but it remains to be seen to what extent PD-L1 IHC will be implemented in the clinical routine. More... »

PAGES

557-567

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00292-016-0189-1

DOI

http://dx.doi.org/10.1007/s00292-016-0189-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046079537

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27510417


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00292-016-0189-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00292-016-0189-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00292-016-0189-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00292-016-0189-1'


 

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304 schema:name Institut für Pathologie, Universitätsklinikum Heidelberg, Heidelberg, Deutschland
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306 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
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