Molekulare Pathologie des kolorektalen Karzinoms View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-03

AUTHORS

J.H.L. Neumann, A. Jung, T. Kirchner

ABSTRACT

In recent years, several predictive and prognostic biomarkers have been established in colorectal cancer (CRC). The RAS-mutation status is widely applied in the daily routine diagnostic as predictive biomarker for treatment with EGFR-inhibitors. A BRAF- mutation has no predictive value in this context. The detection of high-grade microsatellite instability (MSI-H) is a predictive biomarker for response to 5-Fluoruracil-monotherapy. Prognostic biomarkers in CRC are the MSI-status and the mutational status of BRAF. According to the current WHO classification poorly and undifferentiated CRC and MSI-associated special morphological subtypes are molecular graded depending on their MSI-status. The detection of a BRAF-mutation in the context of microsatellite stability (MSS) is associated with a very poor prognosis and thus represents the most aggressive molecular subtype of CRC. In patients with positive Bethesda criteria a stepwise immunohistochemical and molecular diagnostic scheme is proposed. More... »

PAGES

137-144

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00292-015-0005-3

DOI

http://dx.doi.org/10.1007/s00292-015-0005-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028062446

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25777075


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