Polyethylene glycol–gum acacia-based multidrug delivery system for controlled delivery of anticancer drugs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12-06

AUTHORS

V. O. Fasiku, B. A. Aderibigbe, E. R. Sadiku, Y. Lemmer, S. J. Owonubi, S. S. Ray, E. Mukwevho

ABSTRACT

Breast cancer is a chronic disease that is characterized by an uncontrolled growth of abnormal cells from the breast tissue. It is one of the leading causes of mortality among women worldwide because of its early metastasis, aggressive behavior and resistance to the currently used anticancer drugs. Most of these drugs suffer from poor absorption and toxicity, and lack long-term efficaciousness because of drug resistance. Recently, polymeric thermosensitive hydrogels have emerged as excellent drug delivery systems for anticancer drugs with the potential to improve the overall therapeutic effect of the incorporated drug. In this current research, doxorubicin and curcumin were loaded into biodegradable PEG–gum acacia-based hydrogels. These hydrogels were pH-sensitive, biodegradable and non-toxic. The release mechanism of the drugs from the hydrogels was pH-dependent. In vitro cytotoxicity studies on MCF-7 cancer cell lines further confirmed that the incorporation of doxorubicin and curcumin into the hydrogels resulted in significant cytotoxic effect when compared to the free drugs, suggesting that these hydrogels are potential dual-drug delivery systems. The cytotoxic effect was dose- and time-dependent. More... »

PAGES

1-27

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00289-018-2642-1

DOI

http://dx.doi.org/10.1007/s00289-018-2642-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110405093


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00289-018-2642-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00289-018-2642-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00289-018-2642-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00289-018-2642-1'


 

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286 schema:name DST/CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, 0001, Pretoria, South Africa
287 Department of Applied Chemistry, University of Johannesburg, 2028, Doornfontein, Johannesburg, South Africa
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290 schema:name Department of Chemistry, University of Fort Hare, Alice Campus, Alice, Eastern Cape, South Africa
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293 schema:name Department of Biological Science, North-West University, Private Bag X2046, 2735, Mmabatho, South Africa
294 Department of Chemistry, University of Zululand, KwaDlangezwa, KwaZulu-Natal, South Africa
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297 schema:name CSIR Biosciences, CSIR, 0001, Pretoria, South Africa
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