From Staphylococcus aureus gene regulation to its pattern formation. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-04

AUTHORS

A Oelker, T Horger, C Kuttler

ABSTRACT

The focus of this paper is to develop a new partial differential equation model for the pattern formation of the human pathogen Staphylococcus aureus, starting from a newly developed model of selected gene regulation mechanisms. In our model, we do not only account for the bacteria densities and nutrient concentrations, but also for the quorum sensing and biofilm components, since they enable bacteria to coordinate their behavior and provide the environment in which the colony grows. To this end, we model the relevant gene regulation systems using ordinary differential equations and therefrom derive our evolution equations for quorum sensing and biofilm environment by time-scale arguments. Furthermore, we compare and validate our model and the corresponding simulation results with biological real data observations of Staphylococcus aureus mutant colony growth in the laboratory. We show that we are able to adequately display the qualitative biological features of pattern formation in selected mutants, using the parameter changes indicated by the gene regulation mechanisms. More... »

Journal

TITLE

Journal of Mathematical Biology

ISSUE

N/A

VOLUME

N/A

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00285-019-01340-9

DOI

http://dx.doi.org/10.1007/s00285-019-01340-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113185171

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30949755


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Technische Universit\u00e4t M\u00fcnchen, Boltzmannstrasse 3, 85748, Garching bei M\u00fcnchen, Germany. oelker@ma.tum.de."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oelker", 
        "givenName": "A", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Technische Universit\u00e4t M\u00fcnchen, Boltzmannstrasse 3, 85748, Garching bei M\u00fcnchen, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horger", 
        "givenName": "T", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Technische Universit\u00e4t M\u00fcnchen, Boltzmannstrasse 3, 85748, Garching bei M\u00fcnchen, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuttler", 
        "givenName": "C", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cell.2009.01.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002161508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.resmic.2005.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002946722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.00227-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003036054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.01514-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003243300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro3110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003340227", 
          "https://doi.org/10.1038/nrmicro3110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.71.1.343-353.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004372419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.71.9.5139-5148.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005186327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1109261108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006507173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.187.9.2967-2973.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008987533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c3mb70117d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009308452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1002744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015853049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/s130405130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015927337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.femsre.2003.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016640191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-4371(99)00328-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017310116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro2960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018048206", 
          "https://doi.org/10.1038/nrmicro2960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.02111-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020704678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.00131-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021487636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021626955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.357848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022154504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-662-07232-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022922985", 
          "https://doi.org/10.1007/978-3-662-07232-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-662-07232-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022922985", 
          "https://doi.org/10.1007/978-3-662-07232-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0910560107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022945670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.185.10.3214-3217.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023033915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mma.3322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024905796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jtbi.1997.0462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025164004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4613-0133-2_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028715142", 
          "https://doi.org/10.1007/978-1-4613-0133-2_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4613-0133-2_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028715142", 
          "https://doi.org/10.1007/978-1-4613-0133-2_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci42520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028812223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci42520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028812223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2008.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029037845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rsfs.2013.0051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029045400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/pathogens1010003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029116587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.186.6.1838-1850.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029234395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.74.1.488-496.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032635391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11538-011-9701-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032916049", 
          "https://doi.org/10.1007/s11538-011-9701-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.183.17.5171-5179.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033383742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11538-016-0160-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034724812", 
          "https://doi.org/10.1007/s11538-016-0160-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11538-016-0160-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034724812", 
          "https://doi.org/10.1007/s11538-016-0160-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.187.23.8006-8019.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034872892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1115006109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035536989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.72.7.3838-3848.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036420808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fcimb.2014.00167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037359074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00285-009-0291-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037650140", 
          "https://doi.org/10.1007/s00285-009-0291-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00285-009-0291-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037650140", 
          "https://doi.org/10.1007/s00285-009-0291-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00285-009-0291-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037650140", 
          "https://doi.org/10.1007/s00285-009-0291-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fcimb.2012.00038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039709987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11538-011-9702-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039782413", 
          "https://doi.org/10.1007/s11538-011-9702-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jobm.201400175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041095912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.2003.03493.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041766902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00285-006-0024-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041881446", 
          "https://doi.org/10.1007/s00285-006-0024-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00285-006-0024-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041881446", 
          "https://doi.org/10.1007/s00285-006-0024-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fcimb.2015.00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043298690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.73.7.4391-4394.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046507666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.183.24.7341-7353.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046795855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-4371(00)00085-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047517610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1049394982", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-75934-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049394982", 
          "https://doi.org/10.1007/978-0-387-75934-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-75934-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049394982", 
          "https://doi.org/10.1007/978-0-387-75934-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.00482-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050389446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/imammb/18.3.263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059687982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/mic.0.027417-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060394493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/mic.0.027417-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060394493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.176.2.269-275.1994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062723117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci20442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.28023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091557207"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04-04", 
    "datePublishedReg": "2019-04-04", 
    "description": "The focus of this paper is to develop a new partial differential equation model for the pattern formation of the human pathogen Staphylococcus aureus, starting from a newly developed model of selected gene regulation mechanisms. In our model, we do not only account for the bacteria densities and nutrient concentrations, but also for the quorum sensing and biofilm components, since they enable bacteria to coordinate their behavior and provide the environment in which the colony grows. To this end, we model the relevant gene regulation systems using ordinary differential equations and therefrom derive our evolution equations for quorum sensing and biofilm environment by time-scale arguments. Furthermore, we compare and validate our model and the corresponding simulation results with biological real data observations of Staphylococcus aureus mutant colony growth in the laboratory. We show that we are able to adequately display the qualitative biological features of pattern formation in selected mutants, using the parameter changes indicated by the gene regulation mechanisms.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00285-019-01340-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1081642", 
        "issn": [
          "0303-6812", 
          "1432-1416"
        ], 
        "name": "Journal of Mathematical Biology", 
        "type": "Periodical"
      }
    ], 
    "name": "From Staphylococcus aureus gene regulation to its pattern formation.", 
    "productId": [
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30949755"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7502105"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00285-019-01340-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113185171"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00285-019-01340-9", 
      "https://app.dimensions.ai/details/publication/pub.1113185171"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117091_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00285-019-01340-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00285-019-01340-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00285-019-01340-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00285-019-01340-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00285-019-01340-9'


 

This table displays all metadata directly associated to this object as RDF triples.

247 TRIPLES      20 PREDICATES      80 URIs      16 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00285-019-01340-9 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N65ce5202896942c4bf00cc7a89de5a0b
4 schema:citation sg:pub.10.1007/978-0-387-75934-0
5 sg:pub.10.1007/978-1-4613-0133-2_10
6 sg:pub.10.1007/978-3-662-07232-5
7 sg:pub.10.1007/s00285-006-0024-z
8 sg:pub.10.1007/s00285-009-0291-6
9 sg:pub.10.1007/s11538-011-9701-1
10 sg:pub.10.1007/s11538-011-9702-0
11 sg:pub.10.1007/s11538-016-0160-6
12 sg:pub.10.1038/nrmicro2960
13 sg:pub.10.1038/nrmicro3110
14 https://app.dimensions.ai/details/publication/pub.1049394982
15 https://doi.org/10.1002/jobm.201400175
16 https://doi.org/10.1002/mma.3322
17 https://doi.org/10.1006/jtbi.1997.0462
18 https://doi.org/10.1016/j.cell.2009.01.043
19 https://doi.org/10.1016/j.femsre.2003.09.003
20 https://doi.org/10.1016/j.molcel.2008.08.005
21 https://doi.org/10.1016/j.resmic.2005.01.007
22 https://doi.org/10.1016/s0378-4371(00)00085-6
23 https://doi.org/10.1016/s0378-4371(99)00328-3
24 https://doi.org/10.1039/c3mb70117d
25 https://doi.org/10.1046/j.1365-2958.2003.03493.x
26 https://doi.org/10.1073/pnas.0910560107
27 https://doi.org/10.1073/pnas.1109261108
28 https://doi.org/10.1073/pnas.1115006109
29 https://doi.org/10.1074/jbc.m112.357848
30 https://doi.org/10.1093/imammb/18.3.263
31 https://doi.org/10.1098/rsfs.2013.0051
32 https://doi.org/10.1099/mic.0.027417-0
33 https://doi.org/10.1128/iai.00131-10
34 https://doi.org/10.1128/iai.02111-14
35 https://doi.org/10.1128/iai.71.1.343-353.2003
36 https://doi.org/10.1128/iai.71.9.5139-5148.2003
37 https://doi.org/10.1128/iai.72.7.3838-3848.2004
38 https://doi.org/10.1128/iai.73.7.4391-4394.2005
39 https://doi.org/10.1128/iai.74.1.488-496.2006
40 https://doi.org/10.1128/jb.00227-07
41 https://doi.org/10.1128/jb.00482-08
42 https://doi.org/10.1128/jb.01514-08
43 https://doi.org/10.1128/jb.176.2.269-275.1994
44 https://doi.org/10.1128/jb.183.17.5171-5179.2001
45 https://doi.org/10.1128/jb.183.24.7341-7353.2001
46 https://doi.org/10.1128/jb.185.10.3214-3217.2003
47 https://doi.org/10.1128/jb.186.6.1838-1850.2004
48 https://doi.org/10.1128/jb.187.23.8006-8019.2005
49 https://doi.org/10.1128/jb.187.9.2967-2973.2005
50 https://doi.org/10.1172/jci20442
51 https://doi.org/10.1172/jci42520
52 https://doi.org/10.1371/journal.ppat.1000052
53 https://doi.org/10.1371/journal.ppat.1002744
54 https://doi.org/10.3389/fcimb.2012.00038
55 https://doi.org/10.3389/fcimb.2014.00167
56 https://doi.org/10.3389/fcimb.2015.00007
57 https://doi.org/10.3390/pathogens1010003
58 https://doi.org/10.3390/s130405130
59 https://doi.org/10.7554/elife.28023
60 schema:datePublished 2019-04-04
61 schema:datePublishedReg 2019-04-04
62 schema:description The focus of this paper is to develop a new partial differential equation model for the pattern formation of the human pathogen Staphylococcus aureus, starting from a newly developed model of selected gene regulation mechanisms. In our model, we do not only account for the bacteria densities and nutrient concentrations, but also for the quorum sensing and biofilm components, since they enable bacteria to coordinate their behavior and provide the environment in which the colony grows. To this end, we model the relevant gene regulation systems using ordinary differential equations and therefrom derive our evolution equations for quorum sensing and biofilm environment by time-scale arguments. Furthermore, we compare and validate our model and the corresponding simulation results with biological real data observations of Staphylococcus aureus mutant colony growth in the laboratory. We show that we are able to adequately display the qualitative biological features of pattern formation in selected mutants, using the parameter changes indicated by the gene regulation mechanisms.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree false
66 schema:isPartOf sg:journal.1081642
67 schema:name From Staphylococcus aureus gene regulation to its pattern formation.
68 schema:productId N431a75ff28b84d6e8bbca8faee7631a8
69 N50cea38d84ee4b37acb9bfbf4ccf1f23
70 Nb54d482e193e456cae4444fe73eaaefb
71 Nec829f4323fc462689e67d7260f10be6
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113185171
73 https://doi.org/10.1007/s00285-019-01340-9
74 schema:sdDatePublished 2019-04-11T14:17
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher Ncb855262d07b4595937b1c39eb6799b9
77 schema:url http://link.springer.com/10.1007/s00285-019-01340-9
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N2f69806e139445ac8f1daad6b20ce812 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
82 schema:familyName Oelker
83 schema:givenName A
84 rdf:type schema:Person
85 N431a75ff28b84d6e8bbca8faee7631a8 schema:name nlm_unique_id
86 schema:value 7502105
87 rdf:type schema:PropertyValue
88 N50cea38d84ee4b37acb9bfbf4ccf1f23 schema:name dimensions_id
89 schema:value pub.1113185171
90 rdf:type schema:PropertyValue
91 N65ce5202896942c4bf00cc7a89de5a0b rdf:first N2f69806e139445ac8f1daad6b20ce812
92 rdf:rest Ne5d031d875704cbb9454327c31c29bdb
93 N886fc047d27f480bb2eb536b5a684f98 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
94 schema:familyName Horger
95 schema:givenName T
96 rdf:type schema:Person
97 N91503b53926d4344ad607cf8a8e89581 rdf:first Nf4f57241d0874d7b9cfcabfdff6e2680
98 rdf:rest rdf:nil
99 Nb54d482e193e456cae4444fe73eaaefb schema:name pubmed_id
100 schema:value 30949755
101 rdf:type schema:PropertyValue
102 Ncb855262d07b4595937b1c39eb6799b9 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 Ne5d031d875704cbb9454327c31c29bdb rdf:first N886fc047d27f480bb2eb536b5a684f98
105 rdf:rest N91503b53926d4344ad607cf8a8e89581
106 Nec829f4323fc462689e67d7260f10be6 schema:name doi
107 schema:value 10.1007/s00285-019-01340-9
108 rdf:type schema:PropertyValue
109 Nf4f57241d0874d7b9cfcabfdff6e2680 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
110 schema:familyName Kuttler
111 schema:givenName C
112 rdf:type schema:Person
113 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
114 schema:name Biological Sciences
115 rdf:type schema:DefinedTerm
116 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
117 schema:name Genetics
118 rdf:type schema:DefinedTerm
119 sg:journal.1081642 schema:issn 0303-6812
120 1432-1416
121 schema:name Journal of Mathematical Biology
122 rdf:type schema:Periodical
123 sg:pub.10.1007/978-0-387-75934-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049394982
124 https://doi.org/10.1007/978-0-387-75934-0
125 rdf:type schema:CreativeWork
126 sg:pub.10.1007/978-1-4613-0133-2_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028715142
127 https://doi.org/10.1007/978-1-4613-0133-2_10
128 rdf:type schema:CreativeWork
129 sg:pub.10.1007/978-3-662-07232-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022922985
130 https://doi.org/10.1007/978-3-662-07232-5
131 rdf:type schema:CreativeWork
132 sg:pub.10.1007/s00285-006-0024-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1041881446
133 https://doi.org/10.1007/s00285-006-0024-z
134 rdf:type schema:CreativeWork
135 sg:pub.10.1007/s00285-009-0291-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037650140
136 https://doi.org/10.1007/s00285-009-0291-6
137 rdf:type schema:CreativeWork
138 sg:pub.10.1007/s11538-011-9701-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032916049
139 https://doi.org/10.1007/s11538-011-9701-1
140 rdf:type schema:CreativeWork
141 sg:pub.10.1007/s11538-011-9702-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039782413
142 https://doi.org/10.1007/s11538-011-9702-0
143 rdf:type schema:CreativeWork
144 sg:pub.10.1007/s11538-016-0160-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034724812
145 https://doi.org/10.1007/s11538-016-0160-6
146 rdf:type schema:CreativeWork
147 sg:pub.10.1038/nrmicro2960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018048206
148 https://doi.org/10.1038/nrmicro2960
149 rdf:type schema:CreativeWork
150 sg:pub.10.1038/nrmicro3110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003340227
151 https://doi.org/10.1038/nrmicro3110
152 rdf:type schema:CreativeWork
153 https://app.dimensions.ai/details/publication/pub.1049394982 schema:CreativeWork
154 https://doi.org/10.1002/jobm.201400175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041095912
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1002/mma.3322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024905796
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1006/jtbi.1997.0462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025164004
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/j.cell.2009.01.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002161508
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.femsre.2003.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016640191
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.molcel.2008.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029037845
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.resmic.2005.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002946722
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/s0378-4371(00)00085-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047517610
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/s0378-4371(99)00328-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017310116
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1039/c3mb70117d schema:sameAs https://app.dimensions.ai/details/publication/pub.1009308452
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1046/j.1365-2958.2003.03493.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041766902
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1073/pnas.0910560107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022945670
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1073/pnas.1109261108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006507173
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1073/pnas.1115006109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035536989
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1074/jbc.m112.357848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022154504
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1093/imammb/18.3.263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059687982
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1098/rsfs.2013.0051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029045400
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1099/mic.0.027417-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060394493
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1128/iai.00131-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021487636
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1128/iai.02111-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020704678
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1128/iai.71.1.343-353.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004372419
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1128/iai.71.9.5139-5148.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005186327
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1128/iai.72.7.3838-3848.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036420808
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1128/iai.73.7.4391-4394.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046507666
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1128/iai.74.1.488-496.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032635391
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1128/jb.00227-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003036054
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1128/jb.00482-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050389446
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1128/jb.01514-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003243300
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1128/jb.176.2.269-275.1994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062723117
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1128/jb.183.17.5171-5179.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033383742
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1128/jb.183.24.7341-7353.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046795855
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1128/jb.185.10.3214-3217.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023033915
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1128/jb.186.6.1838-1850.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029234395
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1128/jb.187.23.8006-8019.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034872892
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1128/jb.187.9.2967-2973.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008987533
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1172/jci20442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416444
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1172/jci42520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028812223
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1371/journal.ppat.1000052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021626955
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1371/journal.ppat.1002744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015853049
231 rdf:type schema:CreativeWork
232 https://doi.org/10.3389/fcimb.2012.00038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039709987
233 rdf:type schema:CreativeWork
234 https://doi.org/10.3389/fcimb.2014.00167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037359074
235 rdf:type schema:CreativeWork
236 https://doi.org/10.3389/fcimb.2015.00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043298690
237 rdf:type schema:CreativeWork
238 https://doi.org/10.3390/pathogens1010003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029116587
239 rdf:type schema:CreativeWork
240 https://doi.org/10.3390/s130405130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015927337
241 rdf:type schema:CreativeWork
242 https://doi.org/10.7554/elife.28023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091557207
243 rdf:type schema:CreativeWork
244 https://www.grid.ac/institutes/grid.6936.a schema:alternateName Technical University Munich
245 schema:name Technische Universität München, Boltzmannstrasse 3, 85748, Garching bei München, Germany.
246 Technische Universität München, Boltzmannstrasse 3, 85748, Garching bei München, Germany. oelker@ma.tum.de.
247 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...