Monocyte and macrophage immunometabolism in atherosclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02

AUTHORS

Laszlo Groh, Samuel T. Keating, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen

ABSTRACT

Atherosclerosis is characterized by chronic low grade inflammation of arteries that results in the development of lipid dense plaques. Chronic inflammation induced by Western-type diet is associated with the risk of developing atherosclerosis, and new insights shed light on the importance of metabolic and functional reprogramming in monocytes and macrophages for progression of atherosclerosis. This review aims to provide an overview of our current understanding into how the metabolic reprogramming of glucose, cholesterol, fatty acid, and amino acid metabolism in macrophages contributes to inflammation during atherosclerosis. Recent insights suggest that transcriptional and epigenetic adaptation within innate immune cells (termed trained immunity) play an important role in the pathogenesis of atherosclerosis. We propose that metabolic changes induced by pro-atherogenic lipoproteins partly mediate these changes in trained macrophages. Finally, we discuss the possibility of manipulating cellular metabolism of immune cells for targeted therapeutic intervention against atherosclerosis. More... »

PAGES

203-214

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00281-017-0656-7

    DOI

    http://dx.doi.org/10.1007/s00281-017-0656-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092053972

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28971272


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