Evaluation of damaged small intestine of mouse following methotrexate administration View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-11

AUTHORS

Michihiko Nakamaru, Yasuhiro Masubuchi, Shizuo Narimatsu, Shoji Awazu, Toshiharu Horie

ABSTRACT

Purpose: Methotrexate (MTX) treatment causes damage to the small intestine, resulting in malabsorption and diarrhea. The active and passive transport capacities of the small intestine are decreased by the treatment. The purpose of this study was to evaluate the damage to the small intestine of mice caused by MTX administration by examining the permeability of the paracellular pathway of the small intestinal epithelium. Methods: MTX was administered orally to male ddY mice once daily for 1–6 days. The permeability of the small intestine to the nonabsorbable markers phenol red (PR) and fluorescein isothiocyanate (FITC) dextrans was examined using everted segments of the intestine. Results: PR and FITC dextran permeation through the small intestine increased significantly in parallel with changes in body weight of the mice, wet weight of the small intestine and chemical composition of the small intestinal epithelium. Conclusions: In addition to changes in permeation through the transcellular pathway reported previously, this study revealed that MTX treatment disorders the paracellular barrier function of the small intestinal epithelium, resulting in increased permeation of nonabsorbable markers via the paracellular pathway of the small intestinal mucosa. The present approach to the examination of the barrier function of the intestinal epithelium could be of great use in evaluating the damage to the small intestine and malabsorption. More... »

PAGES

98-102

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002800050714

DOI

http://dx.doi.org/10.1007/s002800050714

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015512224

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9443621


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticoagulants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimetabolites, Antineoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dextrans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Absorption", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestine, Small", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methotrexate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Permeability", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamaru", 
        "givenName": "Michihiko", 
        "id": "sg:person.01043273431.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043273431.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masubuchi", 
        "givenName": "Yasuhiro", 
        "id": "sg:person.01062163410.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062163410.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Narimatsu", 
        "givenName": "Shizuo", 
        "id": "sg:person.01274515225.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274515225.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biopharmaceutics, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.410785.f", 
          "name": [
            "Department of Biopharmaceutics, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Awazu", 
        "givenName": "Shoji", 
        "id": "sg:person.012506431151.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012506431151.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horie", 
        "givenName": "Toshiharu", 
        "id": "sg:person.015025434461.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015025434461.42"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1997-11", 
    "datePublishedReg": "1997-11-01", 
    "description": "Purpose: Methotrexate (MTX) treatment causes damage to the small intestine, resulting in malabsorption and diarrhea. The active and passive transport capacities of the small intestine are decreased by the treatment. The purpose of this study was to evaluate the damage to the small intestine of mice caused by MTX administration by examining the permeability of the paracellular pathway of the small intestinal epithelium. Methods: MTX was administered orally to male ddY mice once daily for 1\u20136 days. The permeability of the small intestine to the nonabsorbable markers phenol red (PR) and fluorescein isothiocyanate (FITC) dextrans was examined using everted segments of the intestine. Results: PR and FITC dextran permeation through the small intestine increased significantly in parallel with changes in body weight of the mice, wet weight of the small intestine and chemical composition of the small intestinal epithelium. Conclusions: In addition to changes in permeation through the transcellular pathway reported previously, this study revealed that MTX treatment disorders the paracellular barrier function of the small intestinal epithelium, resulting in increased permeation of nonabsorbable markers via the paracellular pathway of the small intestinal mucosa. The present approach to the examination of the barrier function of the intestinal epithelium could be of great use in evaluating the damage to the small intestine and malabsorption.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s002800050714", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "41"
      }
    ], 
    "keywords": [
      "small intestinal epithelium", 
      "small intestine", 
      "intestinal epithelium", 
      "barrier function", 
      "male ddY mice", 
      "small intestinal mucosa", 
      "MTX administration", 
      "methotrexate administration", 
      "methotrexate treatment", 
      "MTX treatment", 
      "ddY mice", 
      "paracellular pathway", 
      "intestinal mucosa", 
      "body weight", 
      "nonabsorbable marker", 
      "mice", 
      "intestine", 
      "epithelium", 
      "malabsorption", 
      "paracellular barrier function", 
      "treatment", 
      "administration", 
      "transcellular pathway", 
      "wet weight", 
      "damage", 
      "pathway", 
      "dextran permeation", 
      "diarrhea", 
      "mucosa", 
      "MTX", 
      "greater use", 
      "weight", 
      "study", 
      "markers", 
      "examination", 
      "days", 
      "changes", 
      "function", 
      "transport capacity", 
      "fluorescein", 
      "dextran", 
      "permeability", 
      "evaluation", 
      "segments", 
      "use", 
      "purpose", 
      "PR", 
      "addition", 
      "permeation", 
      "capacity", 
      "parallel", 
      "approach", 
      "composition", 
      "phenol", 
      "chemical composition", 
      "present approach", 
      "passive transport capacities", 
      "nonabsorbable markers phenol", 
      "markers phenol", 
      "FITC dextran permeation"
    ], 
    "name": "Evaluation of damaged small intestine of mouse following methotrexate administration", 
    "pagination": "98-102", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015512224"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s002800050714"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9443621"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s002800050714", 
      "https://app.dimensions.ai/details/publication/pub.1015512224"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_298.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s002800050714"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s002800050714'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s002800050714'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s002800050714'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s002800050714'


 

This table displays all metadata directly associated to this object as RDF triples.

201 TRIPLES      21 PREDICATES      99 URIs      91 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s002800050714 schema:about N0a31437c9395410486479cc1853fa282
2 N4b562fe20f254e67aa6152351adfedc2
3 N5ef99b5d25ed434f8b467ecc73ce982e
4 N5fa2f1b05c4d4443ae38cc4fff5dcf34
5 N63ab0a1cc1904026a60b1d353d37991a
6 N6b4c1dfa0db74c53b5f03a832cee825b
7 N782048c581a94be5b03e138dfc0143ca
8 N85907e121ac545738b78669d72fa131d
9 Nac9641ced704448e8a5d7f877b1d63f8
10 Nc8b33915a4564a66ac50b8ab4bc0415f
11 Nd748899f10ef4f1e86fa25bbe40bcc90
12 Nf2fac74675554965834202c6fe103be7
13 anzsrc-for:11
14 anzsrc-for:1109
15 schema:author Nc77ac0651f7d44edb714ff6786e4f81a
16 schema:datePublished 1997-11
17 schema:datePublishedReg 1997-11-01
18 schema:description Purpose: Methotrexate (MTX) treatment causes damage to the small intestine, resulting in malabsorption and diarrhea. The active and passive transport capacities of the small intestine are decreased by the treatment. The purpose of this study was to evaluate the damage to the small intestine of mice caused by MTX administration by examining the permeability of the paracellular pathway of the small intestinal epithelium. Methods: MTX was administered orally to male ddY mice once daily for 1–6 days. The permeability of the small intestine to the nonabsorbable markers phenol red (PR) and fluorescein isothiocyanate (FITC) dextrans was examined using everted segments of the intestine. Results: PR and FITC dextran permeation through the small intestine increased significantly in parallel with changes in body weight of the mice, wet weight of the small intestine and chemical composition of the small intestinal epithelium. Conclusions: In addition to changes in permeation through the transcellular pathway reported previously, this study revealed that MTX treatment disorders the paracellular barrier function of the small intestinal epithelium, resulting in increased permeation of nonabsorbable markers via the paracellular pathway of the small intestinal mucosa. The present approach to the examination of the barrier function of the intestinal epithelium could be of great use in evaluating the damage to the small intestine and malabsorption.
19 schema:genre article
20 schema:inLanguage en
21 schema:isAccessibleForFree false
22 schema:isPartOf N35844f995c364275ad18653ab4900df5
23 N35ef640f8e4749ddb558e5ec9c3a4ca9
24 sg:journal.1088364
25 schema:keywords FITC dextran permeation
26 MTX
27 MTX administration
28 MTX treatment
29 PR
30 addition
31 administration
32 approach
33 barrier function
34 body weight
35 capacity
36 changes
37 chemical composition
38 composition
39 damage
40 days
41 ddY mice
42 dextran
43 dextran permeation
44 diarrhea
45 epithelium
46 evaluation
47 examination
48 fluorescein
49 function
50 greater use
51 intestinal epithelium
52 intestinal mucosa
53 intestine
54 malabsorption
55 male ddY mice
56 markers
57 markers phenol
58 methotrexate administration
59 methotrexate treatment
60 mice
61 mucosa
62 nonabsorbable marker
63 nonabsorbable markers phenol
64 paracellular barrier function
65 paracellular pathway
66 parallel
67 passive transport capacities
68 pathway
69 permeability
70 permeation
71 phenol
72 present approach
73 purpose
74 segments
75 small intestinal epithelium
76 small intestinal mucosa
77 small intestine
78 study
79 transcellular pathway
80 transport capacity
81 treatment
82 use
83 weight
84 wet weight
85 schema:name Evaluation of damaged small intestine of mouse following methotrexate administration
86 schema:pagination 98-102
87 schema:productId N06fc38615587411bac73e2fbf8bda915
88 N2373e5ebded24427b7e6f871c0342219
89 N2960c5c3811a4fe9b0abec20277e9630
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015512224
91 https://doi.org/10.1007/s002800050714
92 schema:sdDatePublished 2022-01-01T18:08
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher Nce42db6ffbdb4c6f937b82f1ab8617b1
95 schema:url https://doi.org/10.1007/s002800050714
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N06fc38615587411bac73e2fbf8bda915 schema:name dimensions_id
100 schema:value pub.1015512224
101 rdf:type schema:PropertyValue
102 N0a31437c9395410486479cc1853fa282 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Body Weight
104 rdf:type schema:DefinedTerm
105 N176ddedc809b4e5a96fd0bace8d92ac8 rdf:first sg:person.01062163410.74
106 rdf:rest N8cf418d8359b4dfdacde52d628db4cba
107 N2373e5ebded24427b7e6f871c0342219 schema:name doi
108 schema:value 10.1007/s002800050714
109 rdf:type schema:PropertyValue
110 N2960c5c3811a4fe9b0abec20277e9630 schema:name pubmed_id
111 schema:value 9443621
112 rdf:type schema:PropertyValue
113 N2a72027e9b5146918589c63903546277 rdf:first sg:person.015025434461.42
114 rdf:rest rdf:nil
115 N35844f995c364275ad18653ab4900df5 schema:issueNumber 2
116 rdf:type schema:PublicationIssue
117 N35ef640f8e4749ddb558e5ec9c3a4ca9 schema:volumeNumber 41
118 rdf:type schema:PublicationVolume
119 N4b562fe20f254e67aa6152351adfedc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Mice
121 rdf:type schema:DefinedTerm
122 N5ef99b5d25ed434f8b467ecc73ce982e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Methotrexate
124 rdf:type schema:DefinedTerm
125 N5fa2f1b05c4d4443ae38cc4fff5dcf34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Intestine, Small
127 rdf:type schema:DefinedTerm
128 N63ab0a1cc1904026a60b1d353d37991a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Administration, Oral
130 rdf:type schema:DefinedTerm
131 N6b4c1dfa0db74c53b5f03a832cee825b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Dextrans
133 rdf:type schema:DefinedTerm
134 N782048c581a94be5b03e138dfc0143ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Anticoagulants
136 rdf:type schema:DefinedTerm
137 N85907e121ac545738b78669d72fa131d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Intestinal Absorption
139 rdf:type schema:DefinedTerm
140 N8cf418d8359b4dfdacde52d628db4cba rdf:first sg:person.01274515225.63
141 rdf:rest Ncc0a48d7977f4f72911ff7eb1e39f436
142 Nac9641ced704448e8a5d7f877b1d63f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Male
144 rdf:type schema:DefinedTerm
145 Nc77ac0651f7d44edb714ff6786e4f81a rdf:first sg:person.01043273431.25
146 rdf:rest N176ddedc809b4e5a96fd0bace8d92ac8
147 Nc8b33915a4564a66ac50b8ab4bc0415f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Permeability
149 rdf:type schema:DefinedTerm
150 Ncc0a48d7977f4f72911ff7eb1e39f436 rdf:first sg:person.012506431151.06
151 rdf:rest N2a72027e9b5146918589c63903546277
152 Nce42db6ffbdb4c6f937b82f1ab8617b1 schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 Nd748899f10ef4f1e86fa25bbe40bcc90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Antimetabolites, Antineoplastic
156 rdf:type schema:DefinedTerm
157 Nf2fac74675554965834202c6fe103be7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Animals
159 rdf:type schema:DefinedTerm
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
164 schema:name Neurosciences
165 rdf:type schema:DefinedTerm
166 sg:journal.1088364 schema:issn 0344-5704
167 1432-0843
168 schema:name Cancer Chemotherapy and Pharmacology
169 schema:publisher Springer Nature
170 rdf:type schema:Periodical
171 sg:person.01043273431.25 schema:affiliation grid-institutes:grid.136304.3
172 schema:familyName Nakamaru
173 schema:givenName Michihiko
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043273431.25
175 rdf:type schema:Person
176 sg:person.01062163410.74 schema:affiliation grid-institutes:grid.136304.3
177 schema:familyName Masubuchi
178 schema:givenName Yasuhiro
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062163410.74
180 rdf:type schema:Person
181 sg:person.012506431151.06 schema:affiliation grid-institutes:grid.410785.f
182 schema:familyName Awazu
183 schema:givenName Shoji
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012506431151.06
185 rdf:type schema:Person
186 sg:person.01274515225.63 schema:affiliation grid-institutes:grid.136304.3
187 schema:familyName Narimatsu
188 schema:givenName Shizuo
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274515225.63
190 rdf:type schema:Person
191 sg:person.015025434461.42 schema:affiliation grid-institutes:grid.136304.3
192 schema:familyName Horie
193 schema:givenName Toshiharu
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015025434461.42
195 rdf:type schema:Person
196 grid-institutes:grid.136304.3 schema:alternateName Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP
197 schema:name Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP
198 rdf:type schema:Organization
199 grid-institutes:grid.410785.f schema:alternateName Department of Biopharmaceutics, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan, JP
200 schema:name Department of Biopharmaceutics, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan, JP
201 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...