Amelioration of methotrexate-induced malabsorption by vitamin A View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-12

AUTHORS

Jun-Ichi Yamamoto, T. Horie, Shoji Awazu

ABSTRACT

Methotrexate (MTX) induces damage to the small intestine, resulting in malabsorption and diarrhea. We found that the coadministration of vitamin A (VA) with MTX protected the small intestine from MTX-induced damage. In this study, the permeability of D-glucose, D-xylose and L-leucine through the small intestine of rats treated with MTX and/or VA was studied using everted segments of small intestine. MTX treatment decreased permeability and VA coadministration prevented the decrease. The transport of D-glucose in the small intestine of MTX plus VA- and VA-treated rats and of control rats followed Michaelis-Menten kinetics, in contrast to the transport kinetics in MTX-treated rats. The pharmacokinetics of orally administered [14C]-D-glucose in control rats and MTX- and/or VA-treated rats was also studied. The bioavailability of D-glucose in MTX-treated rats was lower than in the other three groups. VA coadministration improved the bioavailability of D-glucose. Thus, it seems likely that VA ameliorates MTX-induced malabsorption. More... »

PAGES

239-244

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002800050567

DOI

http://dx.doi.org/10.1007/s002800050567

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049107656

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8996527


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimetabolites, Antineoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Absorption", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestine, Small", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Malabsorption Syndromes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methotrexate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vitamin A", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biopharmaceutics, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.410785.f", 
          "name": [
            "Department of Biopharmaceutics, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Jun-Ichi", 
        "id": "sg:person.0717372416.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717372416.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba-shi, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba-shi, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horie", 
        "givenName": "T.", 
        "id": "sg:person.015025434461.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015025434461.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biopharmaceutics, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.410785.f", 
          "name": [
            "Department of Biopharmaceutics, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Awazu", 
        "givenName": "Shoji", 
        "id": "sg:person.012506431151.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012506431151.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00686170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044656656", 
          "https://doi.org/10.1007/bf00686170"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-12", 
    "datePublishedReg": "1996-12-01", 
    "description": "Abstract\u2003Methotrexate (MTX) induces damage to the small intestine, resulting in malabsorption and diarrhea. We found that the coadministration of vitamin A (VA) with MTX protected the small intestine from MTX-induced damage. In this study, the permeability of D-glucose, D-xylose and L-leucine through the small intestine of rats treated with MTX and/or VA was studied using everted segments of small intestine. MTX treatment decreased permeability and VA coadministration prevented the decrease. The transport of D-glucose in the small intestine of MTX plus VA- and VA-treated rats and of control rats followed Michaelis-Menten kinetics, in contrast to the transport kinetics in MTX-treated rats. The pharmacokinetics of orally administered [14C]-D-glucose in control rats and MTX- and/or VA-treated rats was also studied. The bioavailability of D-glucose in MTX-treated rats was lower than in the other three groups. VA coadministration improved the bioavailability of D-glucose. Thus, it seems likely that VA ameliorates MTX-induced malabsorption.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s002800050567", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "keywords": [
      "small intestine", 
      "vitamin A", 
      "control rats", 
      "MTX treatment", 
      "methotrexate", 
      "rats", 
      "malabsorption", 
      "coadministration", 
      "intestine", 
      "glucose", 
      "diarrhea", 
      "pharmacokinetics", 
      "bioavailability", 
      "damage", 
      "treatment", 
      "amelioration", 
      "group", 
      "Michaelis-Menten kinetics", 
      "decrease", 
      "leucine", 
      "study", 
      "permeability", 
      "contrast", 
      "transport kinetics", 
      "segments", 
      "kinetics", 
      "transport", 
      "xylose", 
      "VA coadministration", 
      "methotrexate-induced malabsorption"
    ], 
    "name": "Amelioration of methotrexate-induced malabsorption by vitamin A", 
    "pagination": "239-244", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049107656"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s002800050567"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8996527"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s002800050567", 
      "https://app.dimensions.ai/details/publication/pub.1049107656"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_306.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s002800050567"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s002800050567'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s002800050567'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s002800050567'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s002800050567'


 

This table displays all metadata directly associated to this object as RDF triples.

157 TRIPLES      22 PREDICATES      69 URIs      60 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s002800050567 schema:about N04e780c398ab4ec19569d398340a274f
2 N21799cd8c9a8419b9a44bba4832984e0
3 N32f589e6e05c40febbf0c8b88d014021
4 N3d56b79516f54f7d86209309f3f01a4b
5 N54b5170c1e3244b8a95313eacc376f16
6 N600abb7fd21648588d2ad290636e80cb
7 N6ba5f54b8eaa47e59789828caa858b9e
8 N7a38591a4c4746c29ded80d1ea94e905
9 N83380b39b02d447e8eeaa93efe6d2c10
10 Nc6674751424948328311007f6ddd2369
11 Nd2a53ce9a1824976b3eda4c03cc76873
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author N7b7f33ad58c6453ca19408435e20aa0b
15 schema:citation sg:pub.10.1007/bf00686170
16 schema:datePublished 1996-12
17 schema:datePublishedReg 1996-12-01
18 schema:description Abstract Methotrexate (MTX) induces damage to the small intestine, resulting in malabsorption and diarrhea. We found that the coadministration of vitamin A (VA) with MTX protected the small intestine from MTX-induced damage. In this study, the permeability of D-glucose, D-xylose and L-leucine through the small intestine of rats treated with MTX and/or VA was studied using everted segments of small intestine. MTX treatment decreased permeability and VA coadministration prevented the decrease. The transport of D-glucose in the small intestine of MTX plus VA- and VA-treated rats and of control rats followed Michaelis-Menten kinetics, in contrast to the transport kinetics in MTX-treated rats. The pharmacokinetics of orally administered [14C]-D-glucose in control rats and MTX- and/or VA-treated rats was also studied. The bioavailability of D-glucose in MTX-treated rats was lower than in the other three groups. VA coadministration improved the bioavailability of D-glucose. Thus, it seems likely that VA ameliorates MTX-induced malabsorption.
19 schema:genre article
20 schema:inLanguage en
21 schema:isAccessibleForFree false
22 schema:isPartOf N73b9d76652354d2f98dd20219ddebca2
23 N96b1b56e43034e1c812d599b2284d194
24 sg:journal.1088364
25 schema:keywords MTX treatment
26 Michaelis-Menten kinetics
27 VA coadministration
28 amelioration
29 bioavailability
30 coadministration
31 contrast
32 control rats
33 damage
34 decrease
35 diarrhea
36 glucose
37 group
38 intestine
39 kinetics
40 leucine
41 malabsorption
42 methotrexate
43 methotrexate-induced malabsorption
44 permeability
45 pharmacokinetics
46 rats
47 segments
48 small intestine
49 study
50 transport
51 transport kinetics
52 treatment
53 vitamin A
54 xylose
55 schema:name Amelioration of methotrexate-induced malabsorption by vitamin A
56 schema:pagination 239-244
57 schema:productId N0437faa6d17c4cd18d9e5f824b854529
58 N7cdc8c9a5a054c1fb92aa0f2aba5f763
59 Nd119602c2e7945c8b4ffbdef694a76b9
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049107656
61 https://doi.org/10.1007/s002800050567
62 schema:sdDatePublished 2022-01-01T18:09
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N8c3e1aaec41f48cbac2ec2e10e6caaef
65 schema:url https://doi.org/10.1007/s002800050567
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N0437faa6d17c4cd18d9e5f824b854529 schema:name doi
70 schema:value 10.1007/s002800050567
71 rdf:type schema:PropertyValue
72 N04e780c398ab4ec19569d398340a274f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Vitamin A
74 rdf:type schema:DefinedTerm
75 N21799cd8c9a8419b9a44bba4832984e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Administration, Oral
77 rdf:type schema:DefinedTerm
78 N32f589e6e05c40febbf0c8b88d014021 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Rats
80 rdf:type schema:DefinedTerm
81 N3d56b79516f54f7d86209309f3f01a4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Glucose
83 rdf:type schema:DefinedTerm
84 N54b5170c1e3244b8a95313eacc376f16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Malabsorption Syndromes
86 rdf:type schema:DefinedTerm
87 N600abb7fd21648588d2ad290636e80cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Intestinal Absorption
89 rdf:type schema:DefinedTerm
90 N6b6acecce3474c11b696aa7ce2a26524 rdf:first sg:person.015025434461.42
91 rdf:rest Ncd0c5115ecdb4ef9abdd2aab70566c4b
92 N6ba5f54b8eaa47e59789828caa858b9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Methotrexate
94 rdf:type schema:DefinedTerm
95 N73b9d76652354d2f98dd20219ddebca2 schema:volumeNumber 39
96 rdf:type schema:PublicationVolume
97 N7a38591a4c4746c29ded80d1ea94e905 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Intestine, Small
99 rdf:type schema:DefinedTerm
100 N7b7f33ad58c6453ca19408435e20aa0b rdf:first sg:person.0717372416.50
101 rdf:rest N6b6acecce3474c11b696aa7ce2a26524
102 N7cdc8c9a5a054c1fb92aa0f2aba5f763 schema:name pubmed_id
103 schema:value 8996527
104 rdf:type schema:PropertyValue
105 N83380b39b02d447e8eeaa93efe6d2c10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Antimetabolites, Antineoplastic
107 rdf:type schema:DefinedTerm
108 N8c3e1aaec41f48cbac2ec2e10e6caaef schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 N96b1b56e43034e1c812d599b2284d194 schema:issueNumber 3
111 rdf:type schema:PublicationIssue
112 Nc6674751424948328311007f6ddd2369 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Amino Acids
114 rdf:type schema:DefinedTerm
115 Ncd0c5115ecdb4ef9abdd2aab70566c4b rdf:first sg:person.012506431151.06
116 rdf:rest rdf:nil
117 Nd119602c2e7945c8b4ffbdef694a76b9 schema:name dimensions_id
118 schema:value pub.1049107656
119 rdf:type schema:PropertyValue
120 Nd2a53ce9a1824976b3eda4c03cc76873 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Animals
122 rdf:type schema:DefinedTerm
123 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
124 schema:name Medical and Health Sciences
125 rdf:type schema:DefinedTerm
126 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
127 schema:name Clinical Sciences
128 rdf:type schema:DefinedTerm
129 sg:journal.1088364 schema:issn 0344-5704
130 1432-0843
131 schema:name Cancer Chemotherapy and Pharmacology
132 schema:publisher Springer Nature
133 rdf:type schema:Periodical
134 sg:person.012506431151.06 schema:affiliation grid-institutes:grid.410785.f
135 schema:familyName Awazu
136 schema:givenName Shoji
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012506431151.06
138 rdf:type schema:Person
139 sg:person.015025434461.42 schema:affiliation grid-institutes:grid.136304.3
140 schema:familyName Horie
141 schema:givenName T.
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015025434461.42
143 rdf:type schema:Person
144 sg:person.0717372416.50 schema:affiliation grid-institutes:grid.410785.f
145 schema:familyName Yamamoto
146 schema:givenName Jun-Ichi
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717372416.50
148 rdf:type schema:Person
149 sg:pub.10.1007/bf00686170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044656656
150 https://doi.org/10.1007/bf00686170
151 rdf:type schema:CreativeWork
152 grid-institutes:grid.136304.3 schema:alternateName Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba-shi, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP
153 schema:name Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba-shi, Chiba 263, Japan Tel. (81)43-290-2934; Fax (81)43-255-1574, JP
154 rdf:type schema:Organization
155 grid-institutes:grid.410785.f schema:alternateName Department of Biopharmaceutics, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan, JP
156 schema:name Department of Biopharmaceutics, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan, JP
157 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...