D-19575—a sugar-linked isophosphoramide mustard derivative exploiting transmembrane glucose transport View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-01

AUTHORS

J. Pohl, B. Bertram, P. Hilgard, M. R. Nowrousian, J. Stüben, M. Wießler

ABSTRACT

D-19575 is a glucose derivative of ifosfamide mustard with a broad spectrum of antitumor activity in animal models. In comparison with ifosfamide, D-19575 is less toxic and is better tolerated by tumor-bearing animals, achieving a better therapeutic efficacy. D-19575 is directly cytotoxic in vitro--in contrast to ifosfamide--and it is possible to modulate this cytotoxicity by inhibition of transmembrane glucose transporters. Correspondingly, renal reabsorption of filtered D-19575 could be blocked by pre- and cotreatment with phlorizin, resulting in a higher urinary excretion of the unchanged drug. The toxicity to white blood cells, colony-forming units (CFU-C), and spleen-cell colony-forming units (CFU-S) is considerably lower for D-19575 as compared with ifosfamide. In conclusion, D-19575 is a new alkylating cytotoxic agent with increased antitumor selectivity, probably caused by an active transmembrane transport mechanism. More... »

PAGES

364-370

References to SciGraph publications

  • 1986-03. In vitro comparative studies of the myelotoxicity and antitumor activity of 6-[bis-(2-chloroethyl)-amino]-6-deoxy-D-glucose versus melphalan utilizing the CFU-C and HTSCA assays in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1986-12. Short communication: Cause and prevention of mafosfamide-induced venous pain in INVESTIGATIONAL NEW DRUGS
  • 1966-06. THE GROWTH OF MOUSE BONE MARROW CELLS IN VITRO in IMMUNOLOGY AND CELL BIOLOGY
  • 1989. Mafosfamide — A Derivative of 4-Hydroxycyclophosphamide in CALCITONINS — PHYSIOLOGICAL AND PHARMACOLOGICAL ASPECTS MAFOSFAMIDE — A DERIVATIVE OF 4-HYDROXYCYCLOPHOSPHAMIDE ENZYMATIC DNA METHYLATION
  • 1955-01. Über neue Zuckerderivate mit zytostatischer Wirksamkeit in THE SCIENCE OF NATURE
  • 1987-11. Endogenous galactoside-binding lectins: a new class of functional tumor cell surface molecules related to metastasis in CANCER AND METASTASIS REVIEWS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s002800050248

    DOI

    http://dx.doi.org/10.1007/s002800050248

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049079436

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7850916


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