Carzelesin phase II study in advanced breast, ovarian, colorectal, gastric, head and neck cancer, non-Hodgkin's lymphoma and malignant melanoma: a ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-08

AUTHORS

Nicholas Pavlidis, Steinar Aamdal, Ahmad Awada, Hilary Calvert, Pierre Fumoleau, Roberto Sorio, Cees Punt, Jaap Verweij, Allan van Oosterom, Rudolf Morant, Jantien Wanders, Axel-R. Hanauske

ABSTRACT

PURPOSE: In a phase II trial, the activity of carzelesin, a cyclopropylpyrroloindole prodrug analog, was assessed. PATIENTS AND METHODS: Carzelesin was used as second- or third-line chemotherapy in patients with breast, ovarian, head and neck cancer and non-Hodgkin's lymphoma, and as first-line chemotherapy in patients with colorectal and gastric cancer and melanoma. The drug was given as a bolus infusion at a 4-weekly dose of 150 microg/m2. A total of 140 patients were entered and a total of 285 courses were administered. RESULTS: In general, the compound was well tolerated. Myelotoxicity was the most common toxicity. Grade 3 and 4 leukopenia was observed in 18.6% of the courses, neutropenia in 20.3%, thrombocytopenia in 16.2% and anemia in 8.7%. Double nadirs were seen in a total of 41 courses for neutrophils, in 40 for leukocytes and in 3 for platelets. Non-hematological toxicity was very mild. Only one partial response in a patient with melanoma was seen. CONCLUSIONS: At this dose and schedule carzelesin did not yield activity in the types of tumors studied. More... »

PAGES

167-171

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002800000134

DOI

http://dx.doi.org/10.1007/s002800000134

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010081203

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10972487


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