Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain. View Full Text


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Article Info

DATE

2019-04-06

AUTHORS

Sara Emad El-Agamy, Amal Kamal Abdel-Aziz, Ahmed Esmat, Samar S Azab

ABSTRACT

Chemobrain refers to a common sequela experienced by a substantial subset of cancer patients exposed to chemotherapeutic treatment, a phenomenon that dramatically deteriorates the survivors' quality of life and prevents them from restoring their pre-cancer life. This review is intended to address the current knowledge regarding the mechanisms underlying the pathophysiology of the chemobrain phenomenon, with special focus on the antineoplastic agent ''doxorubicin'', which has been shown to be implicated in strenuous central neurotoxicity despite being-almost entirely-peripherally confined. Moreover, the assessment of the post-chemotherapy cognitive impairment in both human and animal subjects, and the potential pharmacotherapy and behavioral intervention strategies are reviewed. More... »

References to SciGraph publications

  • 2008-09. Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats in METABOLIC BRAIN DISEASE
  • 2017-04. Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 2008-07. Cognitive function in breast cancer patients prior to adjuvant treatment in BREAST CANCER RESEARCH AND TREATMENT
  • 2016-02. Cancer-treatment-induced neurotoxicity—focus on newer treatments in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2017-12. Characterization and reversal of Doxorubicin-mediated biphasic activation of ERK and persistent excitability in sensory neurons of Aplysia californica in SCIENTIFIC REPORTS
  • 2004-09. Cognitive effects of cytotoxic cancer chemotherapy: Predisposing risk factors and potential treatments in CURRENT PSYCHIATRY REPORTS
  • 2005-11. Electrophysiological Correlates of Information Processing in Breast-Cancer Patients Treated With Adjuvant Chemotherapy in BREAST CANCER RESEARCH AND TREATMENT
  • 2010-05. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? in NATURE REVIEWS NEUROSCIENCE
  • 2009-12. Confronting chemobrain: an in-depth look at survivors’ reports of impact on work, social networks, and health care response in JOURNAL OF CANCER SURVIVORSHIP
  • 2018-07. Astaxanthin Ameliorates Doxorubicin-Induced Cognitive Impairment (Chemobrain) in Experimental Rat Model: Impact on Oxidative, Inflammatory, and Apoptotic Machineries in MOLECULAR NEUROBIOLOGY
  • 2012-09. Tumour necrosis factor - alpha mediated mechanisms of cognitive dysfunction in TRANSLATIONAL NEUROSCIENCE
  • 2013-01. Alterations in brain structure and function in breast cancer survivors: effect of post-chemotherapy interval and relation to oxidative DNA damage in BREAST CANCER RESEARCH AND TREATMENT
  • 2001-11. The Genetics of Cognitive Processes: Candidate Genes in Humans and Animals in BEHAVIOR GENETICS
  • 2016-09. Naringin and Sertraline Ameliorate Doxorubicin-Induced Behavioral Deficits Through Modulation of Serotonin Level and Mitochondrial Complexes Protection Pathway in Rat Hippocampus in NEUROCHEMICAL RESEARCH
  • 2018-02. In vivo neuroimaging and behavioral correlates in a rat model of chemotherapy-induced cognitive dysfunction in BRAIN IMAGING AND BEHAVIOR
  • 2014-06. Physical exercise prevents suppression of hippocampal neurogenesis and reduces cognitive impairment in chemotherapy-treated rats in PSYCHOPHARMACOLOGY
  • 2016-02. A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy in JOURNAL OF CANCER SURVIVORSHIP
  • 2011-09. Chemotherapy and Cognitive Impairment: Treatment Options in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2013-12. The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer in BRAIN IMAGING AND BEHAVIOR
  • 2004-08. Effects of pentoxifylline in Adriamycin-induced renal disease in rats in PEDIATRIC NEPHROLOGY
  • 2008-06. A randomised, placebo-controlled, double-blind trial of the effects of d-methylphenidate on fatigue and cognitive dysfunction in women undergoing adjuvant chemotherapy for breast cancer in SUPPORTIVE CARE IN CANCER
  • 1982-06. Cytofluorescence localization of adriamycin in the nervous system in ACTA NEUROPATHOLOGICA
  • 2010-10. Functions of astrocytes and their potential as therapeutic targets in NEUROTHERAPEUTICS
  • 2010. Chemo Brain (Chemo Fog) as a Potential Side Effect of Doxorubicin Administration: Role of Cytokine-Induced, Oxidative/Nitrosative Stress in Cognitive Dysfunction in CHEMO FOG
  • 2017-01. Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity in NEUROPSYCHOPHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00280-019-03827-0

    DOI

    http://dx.doi.org/10.1007/s00280-019-03827-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113283277

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30955080


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