TGFβ receptor inhibitor galunisertib is linked to inflammation- and remodeling-related proteins in patients with pancreatic cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-18

AUTHORS

Davide Melisi, Rocio Garcia-Carbonero, Teresa Macarulla, Denis Pezet, Gael Deplanque, Martin Fuchs, Jorg Trojan, Mark Kozloff, Francesca Simionato, Ann Cleverly, Claire Smith, Shuaicheng Wang, Michael Man, Kyla E. Driscoll, Shawn T. Estrem, Michael M. F. Lahn, Karim A. Benhadji, Josep Tabernero

ABSTRACT

PurposeGalunisertib, the first small molecule transforming growth factor beta (TGFβ) receptor inhibitor, plus gemcitabine resulted in the improvement of survival in patients with unresectable pancreatic cancer, but markers to identify patients likely to respond are lacking.MethodsIn the Phase 1b/2 JBAJ study, 156 patients were randomized 2:1 to galunisertib + gemcitabine (N = 104) or placebo + gemcitabine (N = 52). Clinical outcome data were integrated with baseline markers and pharmacodynamic markers while patients were on treatment, including circulating proteins using a multi-analyte panel, T cell subset evaluation, and miRNA profiling.ResultsBaseline biomarkers associated with overall prognosis regardless of treatment included CA19-9 and TGF-β1. In addition, IP-10, FSH, MIP-1α, and PAI-1 were potential predictive proteins. Baseline proteins that were changed during treatment included amphiregulin, CA15-3, cathepsin D, P-selectin, RAGE, sortilin, COMP, eotaxin-2, N-BNP, osteopontin, and thrombospondin-4. Plasma miRNA with potential prognostic value included miR-21-5p, miR-301a-3p, miR-210-3p, and miR-141-3p, while those with potential predictive value included miR-424-5p, miR-483-3p, and miR-10b-5p.ConclusionsGalunisertib + gemcitabine resulted in improvement of overall survival, and 4 proteins (IP-10, FSH, MIP-1α, PAI-1) were potentially predictive for this combination treatment. Future studies should also include baseline evaluation of miR-424-5p, miR-483-3p, and miR-10b-5p.Trial registrationClinicaltrials.gov NCT01373164. More... »

PAGES

975-991

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Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-019-03807-4

DOI

http://dx.doi.org/10.1007/s00280-019-03807-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112856012

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30887178


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370 grid-institutes:grid.414363.7 schema:alternateName Medical Oncology, Saint Joseph Hospital, Paris, France
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373 grid-institutes:grid.414617.1 schema:alternateName Ingalls Memorial Hospital, Harvey, IL, USA
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376 grid-institutes:grid.417540.3 schema:alternateName Eli Lilly and Company, Indianapolis, IN, USA
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379 grid-institutes:grid.418786.4 schema:alternateName Eli Lilly and Company, Erl Wood, UK
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382 grid-institutes:grid.419595.5 schema:alternateName Hospital Bogenhausen, Municipal Hospital Munich GmbH, Munich, Germany
383 schema:name Hospital Bogenhausen, Municipal Hospital Munich GmbH, Munich, Germany
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385 grid-institutes:grid.494717.8 schema:alternateName Digestive Surgery Service, CHU Clermont-Ferrand, University Clermont Auvergne, Clermont-Ferrand, France
386 schema:name Digestive Surgery Service, CHU Clermont-Ferrand, University Clermont Auvergne, Clermont-Ferrand, France
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388 grid-institutes:grid.5611.3 schema:alternateName Digestive Molecular Clinical Oncology Research Unit, Section of Medical Oncology, Department of Medicine, Università degli studi di Verona, Piazzale L.A. Scuro, 10, 37134, Verona, Italy
389 schema:name Digestive Molecular Clinical Oncology Research Unit, Section of Medical Oncology, Department of Medicine, Università degli studi di Verona, Piazzale L.A. Scuro, 10, 37134, Verona, Italy
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