Pharmacokinetic and cytokine profiles of melanoma patients with dabrafenib and trametinib-induced pyrexia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Hannah Yejin Kim, Janna K. Duong, Maria Gonzalez, Georgina V. Long, Alexander M. Menzies, Helen Rizos, Su Yin Lim, Jenny Lee, Alan V. Boddy

ABSTRACT

PURPOSE: The combination of a BRAF inhibitor dabrafenib and a MEK inhibitor trametinib (CombiDT) has improved outcomes compared with chemotherapy or BRAF inhibitor monotherapy in advanced BRAF V600E/K melanoma. However, CombiDT causes a high incidence of pyrexia and treatment interruptions. Pharmacokinetic analysis may provide an explanation for the pyrexia. METHODS: 34 patients with Stage 3 BRAF V600 melanoma were treated with CombiDT on a clinical trial between August 2014 and June 2017. Plasma concentrations of drugs and metabolites were determined using validated LC-MS assays, in addition to analysis of a panel of cytokines. RESULTS: Pyrexia was experienced by 71% of the patients, with an additional 17% requiring dose interruption related to a pyrexia-like prodrome. Dabrafenib concentrations ranged from 4.0 to 4628 ng/ml and trametinib from 1.0 to 45 ng/ml in 34 patients. N-desmethyl-dabrafenib was the most prevalent metabolite, followed by carboxy- and hydroxy-dabrafenib. No definitive association between pyrexia and AUC or Cmin of the drugs, or metabolites could be observed. The level of IL-1B at the early during treatment (EDT) (as a % of pre-treatment) was higher in the pyrexia group (median 109% (range 32-681%) than in the no-incidence group [56% (26-79%)] (p = 0.029). Similarly, the level of IL-6 at EDT was higher in the pyrexia group [181% (34-3156%) vs 73% (57-101%)] (p = 0.028). CONCLUSIONS: No apparent associations between pyrexia and exposure to the drugs or metabolites could be observed. Greater elevations in IL-1B and IL-6 were observed in patients with pyrexia during the first week of treatment compared to those without pyrexia. More... »

PAGES

693-704

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-019-03780-y

DOI

http://dx.doi.org/10.1007/s00280-019-03780-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111540864

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30661097


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hannah Yejin", 
        "id": "sg:person.011722644734.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011722644734.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duong", 
        "givenName": "Janna K.", 
        "id": "sg:person.01205727526.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205727526.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Melanoma Institute Australia", 
          "id": "https://www.grid.ac/institutes/grid.419690.3", 
          "name": [
            "Melanoma Institute Australia, Wollstonecraft, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzalez", 
        "givenName": "Maria", 
        "id": "sg:person.015442345024.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015442345024.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal North Shore Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412703.3", 
          "name": [
            "Melanoma Institute Australia, Wollstonecraft, NSW, Australia", 
            "Faculty of Medicine and Health, School of Medicine, The University of Sydney, Sydney, NSW, Australia", 
            "Royal North Shore Hospital, St Leonards, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Long", 
        "givenName": "Georgina V.", 
        "id": "sg:person.0664165567.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664165567.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal North Shore Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412703.3", 
          "name": [
            "Melanoma Institute Australia, Wollstonecraft, NSW, Australia", 
            "Faculty of Medicine and Health, School of Medicine, The University of Sydney, Sydney, NSW, Australia", 
            "Royal North Shore Hospital, St Leonards, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Menzies", 
        "givenName": "Alexander M.", 
        "id": "sg:person.0733110542.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733110542.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Macquarie University", 
          "id": "https://www.grid.ac/institutes/grid.1004.5", 
          "name": [
            "Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Macquarie Park, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rizos", 
        "givenName": "Helen", 
        "id": "sg:person.01101732762.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101732762.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Macquarie University", 
          "id": "https://www.grid.ac/institutes/grid.1004.5", 
          "name": [
            "Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Macquarie Park, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lim", 
        "givenName": "Su Yin", 
        "id": "sg:person.01326163644.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326163644.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Macquarie University", 
          "id": "https://www.grid.ac/institutes/grid.1004.5", 
          "name": [
            "Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Macquarie Park, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jenny", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boddy", 
        "givenName": "Alan V.", 
        "id": "sg:person.01345637110.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345637110.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)60868-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003772891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/pgs.16.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005001107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-016-2993-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005195331", 
          "https://doi.org/10.1007/s00280-016-2993-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmpb.2005.04.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006146346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.blo.0000093914.26658.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007726256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.blo.0000093914.26658.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007726256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcph.263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008830706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jid.5700632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009772826", 
          "https://doi.org/10.1038/sj.jid.5700632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1002011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012824919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.114.057778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012846965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.23519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013201477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-3122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014694049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)60398-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015389206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmpb.2010.04.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017004244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017875293", 
          "https://doi.org/10.1038/nature11814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0050120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019757082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms6694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020390905", 
          "https://doi.org/10.1038/ncomms6694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-13-0642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024541786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1998.tb08310.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026676048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1998.tb08310.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026676048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2005.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027225041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.32.4327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027360666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(88)80766-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029460366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcph.437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031433186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.113.053785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032028352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032122084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1210093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036427533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0000000000000110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037896646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0000000000000110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037896646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-14-0887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038836681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2007.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041010697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1103782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041864150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0000236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042693218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcph.115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044958645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70270-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045691543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1406037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047704810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00498254.2013.831143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047924262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-13-0617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048569433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(15)60898-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050394790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1412690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050664711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1203421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051983710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-2-46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052086336", 
          "https://doi.org/10.1186/1479-5876-2-46"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aia.0b013e318034194e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052860959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aia.0b013e318034194e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052860959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1186/1477-3163-3-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064133351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdx176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085346054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cca.2017.07.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090656913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1708539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091533958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1708539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091533958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1708539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091533958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdx377.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092214723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.13477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093024296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.13477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093024296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/1346-8138.14210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100821009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cpt.1076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101751868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4158/ep-2018-0048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103178314"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "PURPOSE: The combination of a BRAF inhibitor dabrafenib and a MEK inhibitor trametinib (CombiDT) has improved outcomes compared with chemotherapy or BRAF inhibitor monotherapy in advanced BRAF V600E/K melanoma. However, CombiDT causes a high incidence of pyrexia and treatment interruptions. Pharmacokinetic analysis may provide an explanation for the pyrexia.\nMETHODS: 34 patients with Stage 3 BRAF V600 melanoma were treated with CombiDT on a clinical trial between August 2014 and June 2017. Plasma concentrations of drugs and metabolites were determined using validated LC-MS assays, in addition to analysis of a panel of cytokines.\nRESULTS: Pyrexia was experienced by 71% of the patients, with an additional 17% requiring dose interruption related to a pyrexia-like prodrome. Dabrafenib concentrations ranged from 4.0 to 4628\u00a0ng/ml and trametinib from 1.0 to 45\u00a0ng/ml in 34 patients. N-desmethyl-dabrafenib was the most prevalent metabolite, followed by carboxy- and hydroxy-dabrafenib. No definitive association between pyrexia and AUC or Cmin of the drugs, or metabolites could be observed. The level of IL-1B at the early during treatment (EDT) (as a % of pre-treatment) was higher in the pyrexia group (median 109% (range 32-681%) than in the no-incidence group [56% (26-79%)] (p\u2009=\u20090.029). Similarly, the level of IL-6\u00a0at EDT was higher in the pyrexia group [181% (34-3156%) vs 73% (57-101%)] (p\u2009=\u20090.028).\nCONCLUSIONS: No apparent associations between pyrexia and exposure to the drugs or metabolites could be observed. Greater elevations in IL-1B and IL-6 were observed in patients with pyrexia during the first week of treatment compared to those without pyrexia.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00280-019-03780-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "83"
      }
    ], 
    "name": "Pharmacokinetic and cytokine profiles of melanoma patients with dabrafenib and trametinib-induced pyrexia", 
    "pagination": "693-704", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "01a4ebb95b8518d8195f3fc4d2b16e6efccc12418d7f943fa442b40a43842cfd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30661097"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806519"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00280-019-03780-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111540864"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00280-019-03780-y", 
      "https://app.dimensions.ai/details/publication/pub.1111540864"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11719_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00280-019-03780-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00280-019-03780-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00280-019-03780-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00280-019-03780-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-019-03780-y'


 

This table displays all metadata directly associated to this object as RDF triples.

291 TRIPLES      21 PREDICATES      79 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00280-019-03780-y schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N871dbda7241545f889a30781b9a4ff80
4 schema:citation sg:pub.10.1007/s00280-016-2993-y
5 sg:pub.10.1038/nature00766
6 sg:pub.10.1038/nature11814
7 sg:pub.10.1038/ncomms6694
8 sg:pub.10.1038/sj.jid.5700632
9 sg:pub.10.1186/1479-5876-2-46
10 https://doi.org/10.1002/cpt.1076
11 https://doi.org/10.1002/jcph.115
12 https://doi.org/10.1002/jcph.263
13 https://doi.org/10.1002/jcph.437
14 https://doi.org/10.1002/jps.23519
15 https://doi.org/10.1016/0014-5793(88)80766-x
16 https://doi.org/10.1016/j.bbi.2007.12.006
17 https://doi.org/10.1016/j.cca.2017.07.012
18 https://doi.org/10.1016/j.cmpb.2005.04.005
19 https://doi.org/10.1016/j.cmpb.2010.04.018
20 https://doi.org/10.1016/j.humpath.2005.03.015
21 https://doi.org/10.1016/s0140-6736(12)60398-5
22 https://doi.org/10.1016/s0140-6736(12)60868-x
23 https://doi.org/10.1016/s0140-6736(15)60898-4
24 https://doi.org/10.1016/s1470-2045(12)70270-x
25 https://doi.org/10.1056/nejmoa1002011
26 https://doi.org/10.1056/nejmoa1103782
27 https://doi.org/10.1056/nejmoa1203421
28 https://doi.org/10.1056/nejmoa1210093
29 https://doi.org/10.1056/nejmoa1406037
30 https://doi.org/10.1056/nejmoa1412690
31 https://doi.org/10.1056/nejmoa1708539
32 https://doi.org/10.1093/annonc/mdu529
33 https://doi.org/10.1093/annonc/mdx176
34 https://doi.org/10.1093/annonc/mdx377.007
35 https://doi.org/10.1097/01.blo.0000093914.26658.55
36 https://doi.org/10.1097/aia.0b013e318034194e
37 https://doi.org/10.1097/cmr.0000000000000110
38 https://doi.org/10.1111/1346-8138.14210
39 https://doi.org/10.1111/bcp.13477
40 https://doi.org/10.1111/j.1749-6632.1998.tb08310.x
41 https://doi.org/10.1124/dmd.113.053785
42 https://doi.org/10.1124/dmd.114.057778
43 https://doi.org/10.1158/1078-0432.ccr-13-3122
44 https://doi.org/10.1158/1078-0432.ccr-14-0887
45 https://doi.org/10.1158/2159-8290.cd-13-0617
46 https://doi.org/10.1158/2159-8290.cd-13-0642
47 https://doi.org/10.1186/1477-3163-3-6
48 https://doi.org/10.1200/jco.2010.32.4327
49 https://doi.org/10.1371/journal.pmed.0050120
50 https://doi.org/10.1371/journal.pone.0000236
51 https://doi.org/10.2217/pgs.16.4
52 https://doi.org/10.3109/00498254.2013.831143
53 https://doi.org/10.4158/ep-2018-0048
54 schema:datePublished 2019-04
55 schema:datePublishedReg 2019-04-01
56 schema:description PURPOSE: The combination of a BRAF inhibitor dabrafenib and a MEK inhibitor trametinib (CombiDT) has improved outcomes compared with chemotherapy or BRAF inhibitor monotherapy in advanced BRAF V600E/K melanoma. However, CombiDT causes a high incidence of pyrexia and treatment interruptions. Pharmacokinetic analysis may provide an explanation for the pyrexia. METHODS: 34 patients with Stage 3 BRAF V600 melanoma were treated with CombiDT on a clinical trial between August 2014 and June 2017. Plasma concentrations of drugs and metabolites were determined using validated LC-MS assays, in addition to analysis of a panel of cytokines. RESULTS: Pyrexia was experienced by 71% of the patients, with an additional 17% requiring dose interruption related to a pyrexia-like prodrome. Dabrafenib concentrations ranged from 4.0 to 4628 ng/ml and trametinib from 1.0 to 45 ng/ml in 34 patients. N-desmethyl-dabrafenib was the most prevalent metabolite, followed by carboxy- and hydroxy-dabrafenib. No definitive association between pyrexia and AUC or Cmin of the drugs, or metabolites could be observed. The level of IL-1B at the early during treatment (EDT) (as a % of pre-treatment) was higher in the pyrexia group (median 109% (range 32-681%) than in the no-incidence group [56% (26-79%)] (p = 0.029). Similarly, the level of IL-6 at EDT was higher in the pyrexia group [181% (34-3156%) vs 73% (57-101%)] (p = 0.028). CONCLUSIONS: No apparent associations between pyrexia and exposure to the drugs or metabolites could be observed. Greater elevations in IL-1B and IL-6 were observed in patients with pyrexia during the first week of treatment compared to those without pyrexia.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N24bf2056f3714cc88083e6208d3f5ce5
61 N89e7bd83772740829be34f60a93d4db3
62 sg:journal.1088364
63 schema:name Pharmacokinetic and cytokine profiles of melanoma patients with dabrafenib and trametinib-induced pyrexia
64 schema:pagination 693-704
65 schema:productId N38f5f67f4c0e41a48c880618290274ca
66 N5a00fc8c1aa5418aa8bca10362ac702d
67 N6eee95d576494a5badc135cf5869c4c3
68 N97064f61df2c4120a431422f82f11b1b
69 Nbda0c37d5f244dcd85f8878c6efb6833
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111540864
71 https://doi.org/10.1007/s00280-019-03780-y
72 schema:sdDatePublished 2019-04-11T11:20
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Ne97b95b03f9940c398e240abf65cc71d
75 schema:url https://link.springer.com/10.1007%2Fs00280-019-03780-y
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0e19ff425d5a4476b31efb1e302fa91d rdf:first sg:person.01101732762.50
80 rdf:rest Nbfcf2510704f418c8d12fb33a37151a9
81 N24bf2056f3714cc88083e6208d3f5ce5 schema:volumeNumber 83
82 rdf:type schema:PublicationVolume
83 N38f5f67f4c0e41a48c880618290274ca schema:name readcube_id
84 schema:value 01a4ebb95b8518d8195f3fc4d2b16e6efccc12418d7f943fa442b40a43842cfd
85 rdf:type schema:PropertyValue
86 N5a00fc8c1aa5418aa8bca10362ac702d schema:name pubmed_id
87 schema:value 30661097
88 rdf:type schema:PropertyValue
89 N6027e69cbee64ffabf9713a97c6e21a3 rdf:first sg:person.01205727526.48
90 rdf:rest N820aec1118314151a8dad9bea5e0cd61
91 N659d95f111dd4641abaacb361dc0f143 rdf:first sg:person.01345637110.41
92 rdf:rest rdf:nil
93 N6eee95d576494a5badc135cf5869c4c3 schema:name nlm_unique_id
94 schema:value 7806519
95 rdf:type schema:PropertyValue
96 N7f05c06577eb47f1a61a17e117dd9181 rdf:first N96fa4889d74845d084c2dd73e978dc5b
97 rdf:rest N659d95f111dd4641abaacb361dc0f143
98 N820aec1118314151a8dad9bea5e0cd61 rdf:first sg:person.015442345024.21
99 rdf:rest Nb1e8f12f2f5240cdb394f1a83b6cb089
100 N871dbda7241545f889a30781b9a4ff80 rdf:first sg:person.011722644734.55
101 rdf:rest N6027e69cbee64ffabf9713a97c6e21a3
102 N89e7bd83772740829be34f60a93d4db3 schema:issueNumber 4
103 rdf:type schema:PublicationIssue
104 N96fa4889d74845d084c2dd73e978dc5b schema:affiliation https://www.grid.ac/institutes/grid.1004.5
105 schema:familyName Lee
106 schema:givenName Jenny
107 rdf:type schema:Person
108 N97064f61df2c4120a431422f82f11b1b schema:name doi
109 schema:value 10.1007/s00280-019-03780-y
110 rdf:type schema:PropertyValue
111 Nb1e8f12f2f5240cdb394f1a83b6cb089 rdf:first sg:person.0664165567.96
112 rdf:rest Nb989f922ba064cb3966b73df52d125d2
113 Nb989f922ba064cb3966b73df52d125d2 rdf:first sg:person.0733110542.08
114 rdf:rest N0e19ff425d5a4476b31efb1e302fa91d
115 Nbda0c37d5f244dcd85f8878c6efb6833 schema:name dimensions_id
116 schema:value pub.1111540864
117 rdf:type schema:PropertyValue
118 Nbfcf2510704f418c8d12fb33a37151a9 rdf:first sg:person.01326163644.17
119 rdf:rest N7f05c06577eb47f1a61a17e117dd9181
120 Ne97b95b03f9940c398e240abf65cc71d schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
123 schema:name Medical and Health Sciences
124 rdf:type schema:DefinedTerm
125 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
126 schema:name Oncology and Carcinogenesis
127 rdf:type schema:DefinedTerm
128 sg:journal.1088364 schema:issn 0344-5704
129 1432-0843
130 schema:name Cancer Chemotherapy and Pharmacology
131 rdf:type schema:Periodical
132 sg:person.01101732762.50 schema:affiliation https://www.grid.ac/institutes/grid.1004.5
133 schema:familyName Rizos
134 schema:givenName Helen
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101732762.50
136 rdf:type schema:Person
137 sg:person.011722644734.55 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
138 schema:familyName Kim
139 schema:givenName Hannah Yejin
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011722644734.55
141 rdf:type schema:Person
142 sg:person.01205727526.48 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
143 schema:familyName Duong
144 schema:givenName Janna K.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205727526.48
146 rdf:type schema:Person
147 sg:person.01326163644.17 schema:affiliation https://www.grid.ac/institutes/grid.1004.5
148 schema:familyName Lim
149 schema:givenName Su Yin
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326163644.17
151 rdf:type schema:Person
152 sg:person.01345637110.41 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
153 schema:familyName Boddy
154 schema:givenName Alan V.
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345637110.41
156 rdf:type schema:Person
157 sg:person.015442345024.21 schema:affiliation https://www.grid.ac/institutes/grid.419690.3
158 schema:familyName Gonzalez
159 schema:givenName Maria
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015442345024.21
161 rdf:type schema:Person
162 sg:person.0664165567.96 schema:affiliation https://www.grid.ac/institutes/grid.412703.3
163 schema:familyName Long
164 schema:givenName Georgina V.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664165567.96
166 rdf:type schema:Person
167 sg:person.0733110542.08 schema:affiliation https://www.grid.ac/institutes/grid.412703.3
168 schema:familyName Menzies
169 schema:givenName Alexander M.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733110542.08
171 rdf:type schema:Person
172 sg:pub.10.1007/s00280-016-2993-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1005195331
173 https://doi.org/10.1007/s00280-016-2993-y
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/nature00766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023536940
176 https://doi.org/10.1038/nature00766
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/nature11814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017875293
179 https://doi.org/10.1038/nature11814
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/ncomms6694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020390905
182 https://doi.org/10.1038/ncomms6694
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/sj.jid.5700632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009772826
185 https://doi.org/10.1038/sj.jid.5700632
186 rdf:type schema:CreativeWork
187 sg:pub.10.1186/1479-5876-2-46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052086336
188 https://doi.org/10.1186/1479-5876-2-46
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1002/cpt.1076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101751868
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1002/jcph.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044958645
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1002/jcph.263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008830706
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1002/jcph.437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031433186
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1002/jps.23519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013201477
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/0014-5793(88)80766-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029460366
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.bbi.2007.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041010697
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.cca.2017.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090656913
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.cmpb.2005.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006146346
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.cmpb.2010.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017004244
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.humpath.2005.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027225041
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/s0140-6736(12)60398-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015389206
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s0140-6736(12)60868-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003772891
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s0140-6736(15)60898-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050394790
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s1470-2045(12)70270-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045691543
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1056/nejmoa1002011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012824919
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1056/nejmoa1103782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041864150
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1056/nejmoa1203421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051983710
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1056/nejmoa1210093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036427533
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1056/nejmoa1406037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047704810
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1056/nejmoa1412690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050664711
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1056/nejmoa1708539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091533958
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1093/annonc/mdu529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032122084
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1093/annonc/mdx176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085346054
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1093/annonc/mdx377.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092214723
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1097/01.blo.0000093914.26658.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007726256
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1097/aia.0b013e318034194e schema:sameAs https://app.dimensions.ai/details/publication/pub.1052860959
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1097/cmr.0000000000000110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037896646
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/1346-8138.14210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100821009
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1111/bcp.13477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093024296
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1111/j.1749-6632.1998.tb08310.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026676048
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1124/dmd.113.053785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032028352
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1124/dmd.114.057778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012846965
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1158/1078-0432.ccr-13-3122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014694049
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1158/1078-0432.ccr-14-0887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038836681
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1158/2159-8290.cd-13-0617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048569433
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1158/2159-8290.cd-13-0642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024541786
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1186/1477-3163-3-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064133351
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1200/jco.2010.32.4327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027360666
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1371/journal.pmed.0050120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019757082
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1371/journal.pone.0000236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042693218
271 rdf:type schema:CreativeWork
272 https://doi.org/10.2217/pgs.16.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005001107
273 rdf:type schema:CreativeWork
274 https://doi.org/10.3109/00498254.2013.831143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047924262
275 rdf:type schema:CreativeWork
276 https://doi.org/10.4158/ep-2018-0048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103178314
277 rdf:type schema:CreativeWork
278 https://www.grid.ac/institutes/grid.1004.5 schema:alternateName Macquarie University
279 schema:name Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Macquarie Park, NSW, Australia
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.1013.3 schema:alternateName University of Sydney
282 schema:name Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW, Australia
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.412703.3 schema:alternateName Royal North Shore Hospital
285 schema:name Faculty of Medicine and Health, School of Medicine, The University of Sydney, Sydney, NSW, Australia
286 Melanoma Institute Australia, Wollstonecraft, NSW, Australia
287 Royal North Shore Hospital, St Leonards, NSW, Australia
288 rdf:type schema:Organization
289 https://www.grid.ac/institutes/grid.419690.3 schema:alternateName Melanoma Institute Australia
290 schema:name Melanoma Institute Australia, Wollstonecraft, NSW, Australia
291 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...