Sunitinib is effective and tolerable in Chinese patients with advanced pancreatic neuroendocrine tumors: a multicenter retrospective study in China View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07-13

AUTHORS

Yuhong Wang, Kaizhou Jin, Huangying Tan, Pan Zhang, Qiuchen Yang, Wei Wang, Jie Li, Chenghao Shao, Ling Xue, Shiting Feng, Minhu Chen, Xianjun Yu, Jie Chen

ABSTRACT

Purpose To determine the efficacy and safety of sunitinib in Chinese patients with unresectable or metastatic pancreatic neuroendocrine tumors (pNETs) and the clinical significance of steady-state sunitinib serum concentrations.MethodsWe conducted a multicenter retrospective study including six centers from across China. A total of 60 patients with unresectable or metastatic pNETs who were treated with sunitinib were evaluated retrospectively.ResultsThe median overall survival (OS) was 47.5 months and the median time to progression (TTP) was 15.3 months. The objective response rate was 5.0%, and the stable disease (SD) rate was 81.7%. About 35.2% of patients required a dosage decrease from 37.5 to 25 mg/day due to adverse events, which in most cases were alleviated or disappeared with the dosage reduction. In 14 patients who experienced sunitinib-related hypertension, 2 achieved a partial response (PR) and 11 had SD. The median OS and TTP of these 14 patients experienced hypertension were both not reached. The median Css of sunitinib was similar between patients treated with sunitinib 37.5 and 25 mg/day (P = 0.955), but higher in patients who had PR than in those who achieved SD or progressive disease, although no statistically significant difference was found (P = 0.173).ConclusionsSunitinib had similar treatment efficacy to western patients with pNET in China. A 25 mg/day dosage was better tolerated than 37.5 mg/day in Chinese patients, and there were no significant differences in sunitinib Css between the two dosage groups. Patients with higher sunitinib Css seem to have better efficacy. Sunitinib-related hypertension may be a predictor of a better treatment effect. More... »

PAGES

507-516

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-017-3367-9

DOI

http://dx.doi.org/10.1007/s00280-017-3367-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090662200

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28707013


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24 schema:description Purpose To determine the efficacy and safety of sunitinib in Chinese patients with unresectable or metastatic pancreatic neuroendocrine tumors (pNETs) and the clinical significance of steady-state sunitinib serum concentrations.MethodsWe conducted a multicenter retrospective study including six centers from across China. A total of 60 patients with unresectable or metastatic pNETs who were treated with sunitinib were evaluated retrospectively.ResultsThe median overall survival (OS) was 47.5 months and the median time to progression (TTP) was 15.3 months. The objective response rate was 5.0%, and the stable disease (SD) rate was 81.7%. About 35.2% of patients required a dosage decrease from 37.5 to 25 mg/day due to adverse events, which in most cases were alleviated or disappeared with the dosage reduction. In 14 patients who experienced sunitinib-related hypertension, 2 achieved a partial response (PR) and 11 had SD. The median OS and TTP of these 14 patients experienced hypertension were both not reached. The median Css of sunitinib was similar between patients treated with sunitinib 37.5 and 25 mg/day (P = 0.955), but higher in patients who had PR than in those who achieved SD or progressive disease, although no statistically significant difference was found (P = 0.173).ConclusionsSunitinib had similar treatment efficacy to western patients with pNET in China. A 25 mg/day dosage was better tolerated than 37.5 mg/day in Chinese patients, and there were no significant differences in sunitinib Css between the two dosage groups. Patients with higher sunitinib Css seem to have better efficacy. Sunitinib-related hypertension may be a predictor of a better treatment effect.
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31 schema:keywords CS
32 China
33 Chinese patients
34 ConclusionsSunitinib
35 MethodsWe
36 SD
37 TTP
38 Western patients
39 advanced pancreatic neuroendocrine tumors
40 adverse events
41 better efficacy
42 better treatment effect
43 cases
44 center
45 clinical significance
46 concentration
47 day dosage
48 days
49 decrease
50 differences
51 disease
52 disease rates
53 dosage
54 dosage decrease
55 dosage groups
56 dosage reduction
57 effect
58 efficacy
59 events
60 group
61 higher sunitinib Css
62 hypertension
63 median Css
64 median overall survival
65 median time
66 metastatic pancreatic neuroendocrine tumors
67 months
68 most cases
69 multicenter retrospective study
70 neuroendocrine tumors
71 objective response rate
72 overall survival
73 pancreatic neuroendocrine tumors
74 partial response
75 patients
76 predictors
77 progression
78 progressive disease
79 purpose
80 rate
81 reduction
82 response
83 response rate
84 retrospective study
85 safety
86 safety of sunitinib
87 serum concentrations
88 significance
89 significant differences
90 similar treatment efficacy
91 stable disease rate
92 steady-state sunitinib serum concentrations
93 study
94 sunitinib
95 sunitinib 37.5
96 sunitinib Css
97 sunitinib serum concentrations
98 sunitinib-related hypertension
99 survival
100 time
101 total
102 treatment effects
103 treatment efficacy
104 tumors
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