Potential drug–drug interactions with abiraterone in metastatic castration-resistant prostate cancer patients: a prevalence study in France View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-05

AUTHORS

Clément Bonnet, Pascaline Boudou-Rouquette, Esther Azoulay-Rutman, Olivier Huillard, Jean-Louis Golmard, Edith Carton, Gaëlle Noé, Michel Vidal, Galdric Orvoen, Anne Chah Wakilian, Clémentine Villeminey, Benoit Blanchet, Jérôme Alexandre, François Goldwasser, Audrey Thomas-Schoemann

ABSTRACT

PURPOSE: Abiraterone acetate combined with prednisone improves survival in metastatic castration-resistant prostate cancer (mCRPC) patients. This oral anticancer agent may result in drug-drug interactions (DDI). We aimed to evaluate the prevalence of DDI with abiraterone and the possible determinants for the occurrence of these DDI. METHODS: We performed a single centre retrospective review from electronic medical records of mCRPC patients treated with abiraterone from 2011 to 2015. Potential DDI with abiraterone were identified using Micromedex and were categorized by a 4-point scale severity. RESULTS: Seventy-two out of ninety-five mCRPC pts (median age: 77 years [68-82]) had comorbidities. The median number of drugs used per patient was 7 [5-9]. 66 potential DDI with abiraterone were detected in 49 patients (52%): 39 and 61% were classified as major and moderate DDI, respectively. In the univariate analysis, pain (p < 0.0001), hypo-albuminemia (p = 0.032), and higher ECOG performance status (PS) (p = 0.013) were significantly associated with a higher risk of DDI with abiraterone. Pain (p < 0.0001) and PS (p = 0.018) remained significant in the multivariate analysis. CONCLUSIONS: Polypharmacy is an issue among mCRPC patients. In our study, half of the patients have potential DDI with abiraterone. Patients with pain and poor PS are at higher risk of DDI with abiraterone. A medication review by a pharmacist is of crucial importance to prevent DDI with abiraterone. More... »

PAGES

1051-1055

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-017-3291-z

DOI

http://dx.doi.org/10.1007/s00280-017-3291-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084020522

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28361167


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Androstenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Comorbidity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Sectional Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electronic Health Records", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "France", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharmacists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polypharmacy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms, Castration-Resistant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, Service de Canc\u00e9rologie m\u00e9dicale, H\u00f4pital Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonnet", 
        "givenName": "Cl\u00e9ment", 
        "id": "sg:person.0601145354.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601145354.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, Service de Canc\u00e9rologie m\u00e9dicale, H\u00f4pital Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boudou-Rouquette", 
        "givenName": "Pascaline", 
        "id": "sg:person.01010724602.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010724602.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, Unit\u00e9 Fonctionnelle de Pharmacocin\u00e9tique et Pharmacochimie, H\u00f4pital Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Azoulay-Rutman", 
        "givenName": "Esther", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, Service de Canc\u00e9rologie m\u00e9dicale, H\u00f4pital Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huillard", 
        "givenName": "Olivier", 
        "id": "sg:person.01014731372.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014731372.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, D\u00e9partement de Biostatistiques, H\u00f4pital Piti\u00e9- Salp\u00e9tri\u00e8re, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Golmard", 
        "givenName": "Jean-Louis", 
        "id": "sg:person.01173417137.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173417137.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, Service de Canc\u00e9rologie m\u00e9dicale, H\u00f4pital Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carton", 
        "givenName": "Edith", 
        "id": "sg:person.0677154170.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677154170.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, Unit\u00e9 Fonctionnelle de Pharmacocin\u00e9tique et Pharmacochimie, H\u00f4pital Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "No\u00e9", 
        "givenName": "Ga\u00eblle", 
        "id": "sg:person.01006222554.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006222554.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University", 
          "id": "https://www.grid.ac/institutes/grid.10992.33", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, Unit\u00e9 Fonctionnelle de Pharmacocin\u00e9tique et Pharmacochimie, H\u00f4pital Cochin, Paris, France", 
            "UMR8638 CNRS, UFR De Pharmacie, Universit\u00e9 Paris Descartes, PRES Sorbonne Paris Cit\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vidal", 
        "givenName": "Michel", 
        "id": "sg:person.01216754433.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216754433.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University", 
          "id": "https://www.grid.ac/institutes/grid.10992.33", 
          "name": [
            "Service de G\u00e9riatrie, H\u00f4pital Broca, H\u00f4pitaux Paris Centre, Universit\u00e9 Paris Descartes, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orvoen", 
        "givenName": "Galdric", 
        "id": "sg:person.0730533223.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730533223.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University", 
          "id": "https://www.grid.ac/institutes/grid.10992.33", 
          "name": [
            "Service de G\u00e9riatrie, H\u00f4pital Broca, H\u00f4pitaux Paris Centre, Universit\u00e9 Paris Descartes, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chah Wakilian", 
        "givenName": "Anne", 
        "id": "sg:person.015304635533.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015304635533.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, Service de Canc\u00e9rologie m\u00e9dicale, H\u00f4pital Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Villeminey", 
        "givenName": "Cl\u00e9mentine", 
        "id": "sg:person.011141525143.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011141525143.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, Unit\u00e9 Fonctionnelle de Pharmacocin\u00e9tique et Pharmacochimie, H\u00f4pital Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blanchet", 
        "givenName": "Benoit", 
        "id": "sg:person.0700337302.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700337302.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, Service de Canc\u00e9rologie m\u00e9dicale, H\u00f4pital Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alexandre", 
        "givenName": "J\u00e9r\u00f4me", 
        "id": "sg:person.013564231252.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013564231252.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, Service de Canc\u00e9rologie m\u00e9dicale, H\u00f4pital Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goldwasser", 
        "givenName": "Fran\u00e7ois", 
        "id": "sg:person.0731567765.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731567765.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University", 
          "id": "https://www.grid.ac/institutes/grid.10992.33", 
          "name": [
            "Assistance publique des H\u00f4pitaux de Paris, Unit\u00e9 Fonctionnelle de Pharmacocin\u00e9tique et Pharmacochimie, H\u00f4pital Cochin, Paris, France", 
            "UMR8638 CNRS, UFR De Pharmacie, Universit\u00e9 Paris Descartes, PRES Sorbonne Paris Cit\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas-Schoemann", 
        "givenName": "Audrey", 
        "id": "sg:person.0674476202.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674476202.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2007.10.6559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001686464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cger.2012.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003372111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jgo.2012.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009913169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.116.070672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009956783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinthera.2009.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016127085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1014618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018044872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-7843.2011.00814.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020226288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40265-015-0435-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021158058", 
          "https://doi.org/10.1007/s40265-015-0435-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-012-2001-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022092108", 
          "https://doi.org/10.1007/s00280-012-2001-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00228-016-2120-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022993696", 
          "https://doi.org/10.1007/s00228-016-2120-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00228-016-2120-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022993696", 
          "https://doi.org/10.1007/s00228-016-2120-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70040-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025804688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00228-014-1799-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034417672", 
          "https://doi.org/10.1007/s00228-014-1799-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1209096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034543175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cpdd.132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037236754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcph.564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037415569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.critrevonc.2013.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037844375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11592620-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041832036", 
          "https://doi.org/10.2165/11592620-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40266-014-0224-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042807772", 
          "https://doi.org/10.1007/s40266-014-0224-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40262-016-0403-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050010773", 
          "https://doi.org/10.1007/s40262-016-0403-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40262-016-0403-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050010773", 
          "https://doi.org/10.1007/s40262-016-0403-6"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-05", 
    "datePublishedReg": "2017-05-01", 
    "description": "PURPOSE: Abiraterone acetate combined with prednisone improves survival in metastatic castration-resistant prostate cancer (mCRPC) patients. This oral anticancer agent may result in drug-drug interactions (DDI). We aimed to evaluate the prevalence of DDI with abiraterone and the possible determinants for the occurrence of these DDI.\nMETHODS: We performed a single centre retrospective review from electronic medical records of mCRPC patients treated with abiraterone from 2011 to 2015. Potential DDI with abiraterone were identified using Micromedex and were categorized by a 4-point scale severity.\nRESULTS: Seventy-two out of ninety-five mCRPC pts (median age: 77 years [68-82]) had comorbidities. The median number of drugs used per patient was 7 [5-9]. 66 potential DDI with abiraterone were detected in 49 patients (52%): 39 and 61% were classified as major and moderate DDI, respectively. In the univariate analysis, pain (p\u2009<\u20090.0001), hypo-albuminemia (p\u2009=\u20090.032), and higher ECOG performance status (PS) (p\u2009=\u20090.013) were significantly associated with a higher risk of DDI with abiraterone. Pain (p\u2009<\u20090.0001) and PS (p\u2009=\u20090.018) remained significant in the multivariate analysis.\nCONCLUSIONS: Polypharmacy is an issue among mCRPC patients. In our study, half of the patients have potential DDI with abiraterone. Patients with pain and poor PS are at higher risk of DDI with abiraterone. A medication review by a pharmacist is of crucial importance to prevent DDI with abiraterone.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00280-017-3291-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "79"
      }
    ], 
    "name": "Potential drug\u2013drug interactions with abiraterone in metastatic castration-resistant prostate cancer patients: a prevalence study in France", 
    "pagination": "1051-1055", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f0e10229911c74bce57b67e3911ed193c6917b9ed4dc7825bef27ac4bd001a95"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28361167"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806519"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00280-017-3291-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084020522"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00280-017-3291-z", 
      "https://app.dimensions.ai/details/publication/pub.1084020522"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54301_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00280-017-3291-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00280-017-3291-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00280-017-3291-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00280-017-3291-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-017-3291-z'


 

This table displays all metadata directly associated to this object as RDF triples.

315 TRIPLES      21 PREDICATES      67 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00280-017-3291-z schema:about N0ccaf8762c03417db2070fe2297ca47b
2 N1a32a77d58a04fbf8ada9caa649d09dd
3 N3aebe488edd54f49a15e74a31bb13716
4 N4db4c9172b3b4887a9596c6b7d0f51d4
5 N61824045844d481ba7e08eb3263436e6
6 N7286ac8169d14c0bade0a97ceb45867d
7 N7376433a36ac4b0dbb68abed39685d31
8 N7b75193733294c39aaa5d82643a945b0
9 Naf90ab8943e24bd3bb329648b3ceb49b
10 Nb578c19b0d704631bcd1456f3ac1329c
11 Nb5c4367e521a4ed491700081afa84a1c
12 Nbe1254a78a73463297186d12936f47c3
13 Nc9fb45969f2848b790b6d4181ecc7731
14 Ncf7015202feb41159f9784921823c725
15 Nd6c00d2b09594e0a93bc9738c1f8c83e
16 Ndf19d297bd0b4920ab8e564a2fa735cd
17 Ne41ef185f5fe4feb8d8de1be6ddf8b2d
18 Ne52ae756cfaa4d979f94920b24f8dd4d
19 Nf0478b5d29914dc69d7dcae9e986b497
20 anzsrc-for:11
21 anzsrc-for:1115
22 schema:author Na5809865753c468a9d96f86d62fddf95
23 schema:citation sg:pub.10.1007/s00228-014-1799-2
24 sg:pub.10.1007/s00228-016-2120-3
25 sg:pub.10.1007/s00280-012-2001-0
26 sg:pub.10.1007/s40262-016-0403-6
27 sg:pub.10.1007/s40265-015-0435-5
28 sg:pub.10.1007/s40266-014-0224-y
29 sg:pub.10.2165/11592620-000000000-00000
30 https://doi.org/10.1002/cpdd.132
31 https://doi.org/10.1002/jcph.564
32 https://doi.org/10.1016/j.cger.2012.01.001
33 https://doi.org/10.1016/j.clinthera.2009.11.008
34 https://doi.org/10.1016/j.critrevonc.2013.08.007
35 https://doi.org/10.1016/j.jgo.2012.02.005
36 https://doi.org/10.1016/s1470-2045(11)70040-7
37 https://doi.org/10.1056/nejmoa1014618
38 https://doi.org/10.1056/nejmoa1209096
39 https://doi.org/10.1111/j.1742-7843.2011.00814.x
40 https://doi.org/10.1124/dmd.116.070672
41 https://doi.org/10.1200/jco.2007.10.6559
42 schema:datePublished 2017-05
43 schema:datePublishedReg 2017-05-01
44 schema:description PURPOSE: Abiraterone acetate combined with prednisone improves survival in metastatic castration-resistant prostate cancer (mCRPC) patients. This oral anticancer agent may result in drug-drug interactions (DDI). We aimed to evaluate the prevalence of DDI with abiraterone and the possible determinants for the occurrence of these DDI. METHODS: We performed a single centre retrospective review from electronic medical records of mCRPC patients treated with abiraterone from 2011 to 2015. Potential DDI with abiraterone were identified using Micromedex and were categorized by a 4-point scale severity. RESULTS: Seventy-two out of ninety-five mCRPC pts (median age: 77 years [68-82]) had comorbidities. The median number of drugs used per patient was 7 [5-9]. 66 potential DDI with abiraterone were detected in 49 patients (52%): 39 and 61% were classified as major and moderate DDI, respectively. In the univariate analysis, pain (p < 0.0001), hypo-albuminemia (p = 0.032), and higher ECOG performance status (PS) (p = 0.013) were significantly associated with a higher risk of DDI with abiraterone. Pain (p < 0.0001) and PS (p = 0.018) remained significant in the multivariate analysis. CONCLUSIONS: Polypharmacy is an issue among mCRPC patients. In our study, half of the patients have potential DDI with abiraterone. Patients with pain and poor PS are at higher risk of DDI with abiraterone. A medication review by a pharmacist is of crucial importance to prevent DDI with abiraterone.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf N69faa237855d4c4e9300593da5de92e7
49 Nc07a67e3dcc24de9b858ff8132417bb6
50 sg:journal.1088364
51 schema:name Potential drug–drug interactions with abiraterone in metastatic castration-resistant prostate cancer patients: a prevalence study in France
52 schema:pagination 1051-1055
53 schema:productId N5eb8817aedd54709a7ff23579bc212c8
54 N9b1ca46bc7314f2d9d03b9c92db5a7e6
55 Nb041e2c3c9f343b2be0864da801be317
56 Nc03fb89d7d0341be89486f2fa85aa027
57 Ndf7d7003193d44c5ba987752b9e4f7d0
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084020522
59 https://doi.org/10.1007/s00280-017-3291-z
60 schema:sdDatePublished 2019-04-11T10:16
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N4b4c05b0b7084f0a87765abfa818db2a
63 schema:url https://link.springer.com/10.1007%2Fs00280-017-3291-z
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N0ccaf8762c03417db2070fe2297ca47b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Neoplasm Metastasis
69 rdf:type schema:DefinedTerm
70 N15fce8e3bc8f4677a30860064c02ff25 rdf:first sg:person.0677154170.26
71 rdf:rest N607330b87edf4e93859711f5c1f79e32
72 N160003ef69284c6fa3d5ca483663ace6 rdf:first sg:person.01216754433.13
73 rdf:rest Na110931d83814945adf8eaa165c334cf
74 N1a32a77d58a04fbf8ada9caa649d09dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Male
76 rdf:type schema:DefinedTerm
77 N213d63c916bd4abe910c5c32062d563a rdf:first sg:person.01010724602.15
78 rdf:rest Nb00f07380780441b80dd35fe36eaabd3
79 N3aebe488edd54f49a15e74a31bb13716 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Aged
81 rdf:type schema:DefinedTerm
82 N4b4c05b0b7084f0a87765abfa818db2a schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N4db4c9172b3b4887a9596c6b7d0f51d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name France
86 rdf:type schema:DefinedTerm
87 N5eb8817aedd54709a7ff23579bc212c8 schema:name pubmed_id
88 schema:value 28361167
89 rdf:type schema:PropertyValue
90 N607330b87edf4e93859711f5c1f79e32 rdf:first sg:person.01006222554.89
91 rdf:rest N160003ef69284c6fa3d5ca483663ace6
92 N61824045844d481ba7e08eb3263436e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Pharmacists
94 rdf:type schema:DefinedTerm
95 N66516d324cf44475a4cf1d3f0bab13c1 rdf:first sg:person.0700337302.68
96 rdf:rest Nd070252e50ca485e9900a8074ccda0cc
97 N69faa237855d4c4e9300593da5de92e7 schema:issueNumber 5
98 rdf:type schema:PublicationIssue
99 N7286ac8169d14c0bade0a97ceb45867d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Pain
101 rdf:type schema:DefinedTerm
102 N7376433a36ac4b0dbb68abed39685d31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Electronic Health Records
104 rdf:type schema:DefinedTerm
105 N7b75193733294c39aaa5d82643a945b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Enzyme Inhibitors
107 rdf:type schema:DefinedTerm
108 N8a086328b4f946729b784122110f0910 rdf:first sg:person.011141525143.06
109 rdf:rest N66516d324cf44475a4cf1d3f0bab13c1
110 N9b1ca46bc7314f2d9d03b9c92db5a7e6 schema:name dimensions_id
111 schema:value pub.1084020522
112 rdf:type schema:PropertyValue
113 Na110931d83814945adf8eaa165c334cf rdf:first sg:person.0730533223.38
114 rdf:rest Na8faba816d2e4be199da38694ecceb6a
115 Na5809865753c468a9d96f86d62fddf95 rdf:first sg:person.0601145354.86
116 rdf:rest N213d63c916bd4abe910c5c32062d563a
117 Na8faba816d2e4be199da38694ecceb6a rdf:first sg:person.015304635533.82
118 rdf:rest N8a086328b4f946729b784122110f0910
119 Naf90ab8943e24bd3bb329648b3ceb49b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Prostatic Neoplasms, Castration-Resistant
121 rdf:type schema:DefinedTerm
122 Nb00f07380780441b80dd35fe36eaabd3 rdf:first Nbabeb119a9334e2081bf442e27ba4e23
123 rdf:rest Nb2c23d60415d45c184d880decd7c3d83
124 Nb041e2c3c9f343b2be0864da801be317 schema:name doi
125 schema:value 10.1007/s00280-017-3291-z
126 rdf:type schema:PropertyValue
127 Nb2c23d60415d45c184d880decd7c3d83 rdf:first sg:person.01014731372.96
128 rdf:rest Nc8021dbd29614e0d97bc4fabf47384aa
129 Nb578c19b0d704631bcd1456f3ac1329c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Humans
131 rdf:type schema:DefinedTerm
132 Nb5c4367e521a4ed491700081afa84a1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Prevalence
134 rdf:type schema:DefinedTerm
135 Nbabeb119a9334e2081bf442e27ba4e23 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
136 schema:familyName Azoulay-Rutman
137 schema:givenName Esther
138 rdf:type schema:Person
139 Nbe1254a78a73463297186d12936f47c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Disease-Free Survival
141 rdf:type schema:DefinedTerm
142 Nc03fb89d7d0341be89486f2fa85aa027 schema:name readcube_id
143 schema:value f0e10229911c74bce57b67e3911ed193c6917b9ed4dc7825bef27ac4bd001a95
144 rdf:type schema:PropertyValue
145 Nc07a67e3dcc24de9b858ff8132417bb6 schema:volumeNumber 79
146 rdf:type schema:PublicationVolume
147 Nc8021dbd29614e0d97bc4fabf47384aa rdf:first sg:person.01173417137.58
148 rdf:rest N15fce8e3bc8f4677a30860064c02ff25
149 Nc84116717ce1445ba86e2a8551e17e64 rdf:first sg:person.0731567765.18
150 rdf:rest Ncc8e0bef1d9049c594a17d90cf694787
151 Nc9fb45969f2848b790b6d4181ecc7731 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Androstenes
153 rdf:type schema:DefinedTerm
154 Ncc8e0bef1d9049c594a17d90cf694787 rdf:first sg:person.0674476202.23
155 rdf:rest rdf:nil
156 Ncf7015202feb41159f9784921823c725 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Comorbidity
158 rdf:type schema:DefinedTerm
159 Nd070252e50ca485e9900a8074ccda0cc rdf:first sg:person.013564231252.87
160 rdf:rest Nc84116717ce1445ba86e2a8551e17e64
161 Nd6c00d2b09594e0a93bc9738c1f8c83e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Retrospective Studies
163 rdf:type schema:DefinedTerm
164 Ndf19d297bd0b4920ab8e564a2fa735cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Cross-Sectional Studies
166 rdf:type schema:DefinedTerm
167 Ndf7d7003193d44c5ba987752b9e4f7d0 schema:name nlm_unique_id
168 schema:value 7806519
169 rdf:type schema:PropertyValue
170 Ne41ef185f5fe4feb8d8de1be6ddf8b2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Polypharmacy
172 rdf:type schema:DefinedTerm
173 Ne52ae756cfaa4d979f94920b24f8dd4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Aged, 80 and over
175 rdf:type schema:DefinedTerm
176 Nf0478b5d29914dc69d7dcae9e986b497 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Drug Interactions
178 rdf:type schema:DefinedTerm
179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
180 schema:name Medical and Health Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
183 schema:name Pharmacology and Pharmaceutical Sciences
184 rdf:type schema:DefinedTerm
185 sg:journal.1088364 schema:issn 0344-5704
186 1432-0843
187 schema:name Cancer Chemotherapy and Pharmacology
188 rdf:type schema:Periodical
189 sg:person.01006222554.89 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
190 schema:familyName Noé
191 schema:givenName Gaëlle
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006222554.89
193 rdf:type schema:Person
194 sg:person.01010724602.15 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
195 schema:familyName Boudou-Rouquette
196 schema:givenName Pascaline
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010724602.15
198 rdf:type schema:Person
199 sg:person.01014731372.96 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
200 schema:familyName Huillard
201 schema:givenName Olivier
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014731372.96
203 rdf:type schema:Person
204 sg:person.011141525143.06 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
205 schema:familyName Villeminey
206 schema:givenName Clémentine
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011141525143.06
208 rdf:type schema:Person
209 sg:person.01173417137.58 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
210 schema:familyName Golmard
211 schema:givenName Jean-Louis
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173417137.58
213 rdf:type schema:Person
214 sg:person.01216754433.13 schema:affiliation https://www.grid.ac/institutes/grid.10992.33
215 schema:familyName Vidal
216 schema:givenName Michel
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216754433.13
218 rdf:type schema:Person
219 sg:person.013564231252.87 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
220 schema:familyName Alexandre
221 schema:givenName Jérôme
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013564231252.87
223 rdf:type schema:Person
224 sg:person.015304635533.82 schema:affiliation https://www.grid.ac/institutes/grid.10992.33
225 schema:familyName Chah Wakilian
226 schema:givenName Anne
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015304635533.82
228 rdf:type schema:Person
229 sg:person.0601145354.86 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
230 schema:familyName Bonnet
231 schema:givenName Clément
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601145354.86
233 rdf:type schema:Person
234 sg:person.0674476202.23 schema:affiliation https://www.grid.ac/institutes/grid.10992.33
235 schema:familyName Thomas-Schoemann
236 schema:givenName Audrey
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674476202.23
238 rdf:type schema:Person
239 sg:person.0677154170.26 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
240 schema:familyName Carton
241 schema:givenName Edith
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677154170.26
243 rdf:type schema:Person
244 sg:person.0700337302.68 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
245 schema:familyName Blanchet
246 schema:givenName Benoit
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700337302.68
248 rdf:type schema:Person
249 sg:person.0730533223.38 schema:affiliation https://www.grid.ac/institutes/grid.10992.33
250 schema:familyName Orvoen
251 schema:givenName Galdric
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730533223.38
253 rdf:type schema:Person
254 sg:person.0731567765.18 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
255 schema:familyName Goldwasser
256 schema:givenName François
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731567765.18
258 rdf:type schema:Person
259 sg:pub.10.1007/s00228-014-1799-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034417672
260 https://doi.org/10.1007/s00228-014-1799-2
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s00228-016-2120-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022993696
263 https://doi.org/10.1007/s00228-016-2120-3
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/s00280-012-2001-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022092108
266 https://doi.org/10.1007/s00280-012-2001-0
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s40262-016-0403-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050010773
269 https://doi.org/10.1007/s40262-016-0403-6
270 rdf:type schema:CreativeWork
271 sg:pub.10.1007/s40265-015-0435-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021158058
272 https://doi.org/10.1007/s40265-015-0435-5
273 rdf:type schema:CreativeWork
274 sg:pub.10.1007/s40266-014-0224-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1042807772
275 https://doi.org/10.1007/s40266-014-0224-y
276 rdf:type schema:CreativeWork
277 sg:pub.10.2165/11592620-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041832036
278 https://doi.org/10.2165/11592620-000000000-00000
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1002/cpdd.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037236754
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1002/jcph.564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037415569
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.cger.2012.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003372111
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.clinthera.2009.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016127085
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.critrevonc.2013.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037844375
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.jgo.2012.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009913169
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/s1470-2045(11)70040-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025804688
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1056/nejmoa1014618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018044872
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1056/nejmoa1209096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034543175
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1111/j.1742-7843.2011.00814.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020226288
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1124/dmd.116.070672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009956783
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1200/jco.2007.10.6559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001686464
303 rdf:type schema:CreativeWork
304 https://www.grid.ac/institutes/grid.10992.33 schema:alternateName Paris Descartes University
305 schema:name Assistance publique des Hôpitaux de Paris, Unité Fonctionnelle de Pharmacocinétique et Pharmacochimie, Hôpital Cochin, Paris, France
306 Service de Gériatrie, Hôpital Broca, Hôpitaux Paris Centre, Université Paris Descartes, Paris, France
307 UMR8638 CNRS, UFR De Pharmacie, Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.411439.a schema:alternateName Pitié-Salpêtrière Hospital
310 schema:name Assistance publique des Hôpitaux de Paris, Département de Biostatistiques, Hôpital Pitié- Salpétrière, Paris, France
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.411784.f schema:alternateName Hôpital Cochin
313 schema:name Assistance publique des Hôpitaux de Paris, Service de Cancérologie médicale, Hôpital Cochin, Paris, France
314 Assistance publique des Hôpitaux de Paris, Unité Fonctionnelle de Pharmacocinétique et Pharmacochimie, Hôpital Cochin, Paris, France
315 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...