Application of bee venom and its main constituent melittin for cancer treatment View Full Text


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Article Info

DATE

2016-09-27

AUTHORS

Cui-cui Liu, Ding-jun Hao, Qian Zhang, Jing An, Jing-jing Zhao, Bo Chen, Ling-ling Zhang, Hao Yang

ABSTRACT

Bee venom and its main constituent melittin (MEL) have been extensively studied in the treatment of tumors. However, the non-specific cytotoxicity and hemolytic activity have hampered the clinical application. Currently, a number of research groups have reported a series of optimization strategies, including gene therapy, recombinant immunotoxin incorporating MEL or MEL nanoparticles, targeting tumor cells to attenuate the cytotoxicity and improve its antitumor efficiency and therapeutic capabilities, which have shown very promising in overcoming some of these obstacles. In this review, we summarize the current knowledge regarding anticancer effects of bee venom and its main compound MEL on different kinds of tumor cells as well as elucidate their possible anticancer mechanisms. It could be concluded that MEL exerts multiple effects on cellular functions of cancerous cells such as proliferation, apoptosis, metastasis, angiogenesis as well as cell cycle, and the anticancer processes involve diverse signal molecules and regulatory pathways. We also highlight the recent research progress for efficient delivery of MEL peptide, thus providing new ideas and hopeful strategies for the in vivo application of MEL. More... »

PAGES

1113-1130

References to SciGraph publications

  • 2016-04-22. Cell Cycle Regulation and Melanoma in CURRENT ONCOLOGY REPORTS
  • 1985-04. Inhibition of growth of leukemic cells by inhibitors of calmodulin: Phenothiazines and melittin in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2010-08-06. Poly(I:C)-Mediated Tumor Growth Suppression in EGF-Receptor Overexpressing Tumors Using EGF-Polyethylene Glycol-Linear Polyethylenimine as Carrier in PHARMACEUTICAL RESEARCH
  • 2010-01-12. Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-κB and AP-1-dependent MMP-9 expression in MOLECULES AND CELLS
  • 2016-01-08. Melittin induces in vitro death of Leishmania (Leishmania) infantum by triggering the cellular innate immune response in JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES
  • 1988-05. Gene products which play a role in cancer invasion and metastasis in BREAST CANCER RESEARCH AND TREATMENT
  • 2014-09-09. Melittin peptides exhibit different activity on different cells and model membranes in AMINO ACIDS
  • 2014-01-01. Co-culture with NK-92MI cells enhanced the anti-cancer effect of bee venom on NSCLC cells by inactivation of NF-κB in ARCHIVES OF PHARMACAL RESEARCH
  • 2014-05-29. Melittin radiosensitizes esophageal squamous cell carcinoma with induction of apoptosis in vitro and in vivo in TUMOR BIOLOGY
  • 2016-06-01. Melittin-MIL-2 fusion protein as a candidate for cancer immunotherapy in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2011-11-23. Bee venom in cancer therapy in CANCER AND METASTASIS REVIEWS
  • 2005-02. A historical review of cellular calcium handling, with emphasis on mitochondria in BIOCHEMISTRY (MOSCOW)
  • 2016-04-28. The role of lymphangiogenesis and angiogenesis in tumor metastasis in CELLULAR ONCOLOGY
  • 2016-03-07. Antimicrobial peptide melittin against Xanthomonas oryzae pv. oryzae, the bacterial leaf blight pathogen in rice in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2004-01-13. Cytotoxic properties of immunoconjugates containing melittin-like peptide 101 against prostate cancer: in vitro and in vivo studies in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2016-04-09. Major apoptotic mechanisms and genes involved in apoptosis in TUMOR BIOLOGY
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    30 schema:description Bee venom and its main constituent melittin (MEL) have been extensively studied in the treatment of tumors. However, the non-specific cytotoxicity and hemolytic activity have hampered the clinical application. Currently, a number of research groups have reported a series of optimization strategies, including gene therapy, recombinant immunotoxin incorporating MEL or MEL nanoparticles, targeting tumor cells to attenuate the cytotoxicity and improve its antitumor efficiency and therapeutic capabilities, which have shown very promising in overcoming some of these obstacles. In this review, we summarize the current knowledge regarding anticancer effects of bee venom and its main compound MEL on different kinds of tumor cells as well as elucidate their possible anticancer mechanisms. It could be concluded that MEL exerts multiple effects on cellular functions of cancerous cells such as proliferation, apoptosis, metastasis, angiogenesis as well as cell cycle, and the anticancer processes involve diverse signal molecules and regulatory pathways. We also highlight the recent research progress for efficient delivery of MEL peptide, thus providing new ideas and hopeful strategies for the in vivo application of MEL.
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    40 anticancer effects
    41 anticancer mechanism
    42 anticancer processes
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    67 hopeful strategy
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    84 peptides
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