GEIS 2013 guidelines for gastrointestinal sarcomas (GIST) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-11

AUTHORS

Andrés Poveda, Xavier García del Muro, Jose Antonio López-Guerrero, Virginia Martínez, Ignacio Romero, Claudia Valverde, Ricardo Cubedo, Javier Martín-Broto

ABSTRACT

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal soft tissue sarcoma of the gastrointestinal tract. Correct diagnosis with thorough use of pathologic and molecular tools of GIST mutations has been of the foremost importance. GIST are usually (95 %) KIT positive and harbor frequent KIT or platelet-derived growth factor receptor α-activating mutations. This deep molecular understanding has allowed the correct classification into risk groups with implications regarding prognosis, essential use in the development of targeted therapies and even response prediction to this drugs. Treatment has been evolving and an update to include lessons learned from recent trials in advanced disease as well as controversies in the adjuvant setting that are changing daily practice, is reviewed here. An effort from the Spanish Group for Sarcoma Research with investigators from the group has been undertaken to launch this third version of the GIST guidelines and provide a practical means for the different disciplines that treat this complex disease. More... »

PAGES

883-898

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-014-2547-0

DOI

http://dx.doi.org/10.1007/s00280-014-2547-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030876107

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25193432


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